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Composite dressing for wound repair and preparation method thereof

A technology of wound repair and cellulose acetate film, which is applied in the manufacture of rayon, artificial filament made of cellulose derivatives, and fiber chemical characteristics, can solve the problems of inability to promote wound healing, long application time, and wound adhesion, etc. problem, to achieve excellent long-term antibacterial effect, inhibit the production of blood vessels, and promote the effect of angiogenesis

Inactive Publication Date: 2021-02-05
杭州鹿扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings represented by gauze, cotton pads, and bandages are the longest-used and cheapest dressings so far. Their disadvantages are that they cannot promote wound healing and are easy to adhere to the wound, causing pain when changing dressings.

Method used

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  • Composite dressing for wound repair and preparation method thereof
  • Composite dressing for wound repair and preparation method thereof
  • Composite dressing for wound repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of cellulose acetate membrane loaded with hyperoside:

[0033] Using the acetone / DMAC system with a volume ratio of 7:3 as a solvent, prepare a cellulose acetate spinning solution with a mass fraction of 11%, add hyperin at a concentration of 16 mg / mL, stir rapidly at room temperature until it is completely dissolved, and obtain an electrostatic Spinning the mother liquor, injecting the electrospinning mother liquor into an electrospinning machine for electrospinning to obtain a cellulose acetate film loaded with hyperin. Spinning process parameter settings: voltage 15KV, injection rate 0.5mL / h, receiving distance 17cm.

[0034] Preparation of composite dressings for wound repair:

[0035] Preparation of regenerated fiber silk membrane: The cellulose acetate membrane loaded with hyperin obtained above was laminated with upper and lower layers of polytetrafluoroethylene sheets, heat treated at 208°C for 1h, and then heated in 0.05mol / L NaOH-water / ethanol ( ...

Embodiment 2

[0038] The difference between the preparation of the hyperin-loaded cellulose acetate membrane and Example 1 lies in that: the mass fraction of cellulose acetate in the electrospinning mother liquor is 13%; the concentration of hyperin is 10 mg / mL.

[0039] The difference in the preparation example 1 of the composite dressing for wound repair is that the concentration of the aqueous collagen solution is 0.08 g / mL.

Embodiment 3

[0041] The difference between the preparation of hyperin-loaded cellulose acetate membrane and Example 1 lies in that: the mass fraction of cellulose acetate in the electrospinning mother liquor is 12%; the concentration of hyperin is 13 mg / mL.

[0042]The difference in the preparation example 1 of the composite dressing for wound repair is that the concentration of the aqueous collagen solution is 0.07 g / mL.

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Abstract

The invention discloses a composite dressing for wound repair and a preparation method thereof, and relates to the technical field of biomedical materials. The preparation method of the composite dressing specifically comprises the following steps that a cellulose membrane compounded by cellulose acetate and hyperoside is prepared by adopting an electrostatic spinning technology, and a regeneratedcellulose membrane M is obtained through high-temperature treatment and hydrolyzing with alkali liquor; and then a collagen aqueous solution is infiltrated through M membrane pores by adopting a pressurized infiltration method, and then the membrane is washed and subjected to freeze-drying to obtain the composite dressing for wound repair. The prepared composite dressing for wound repair has goodmoisture retention, long-acting antibacterial performance and good mechanical performance; regeneration of collagen and blood vessels at wound parts can be promoted, and wound healing is accelerated;and meanwhile, scar formation can be reduced.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a composite dressing for wound repair and a preparation method thereof. Background technique [0002] With the rapid development of modern science and technology, the research on medical dressings has achieved rapid development. Various new types of medical dressings continue to appear, and their performance is getting better and better. However, medical dressings are a type of clinical medical supplies that temporarily cover wounds such as burns, ulcers, and wounds. It has the function of promoting the recovery of wound skin function. As a major exporter of medical dressings, due to low R&D investment and low technical content, domestic dressings are mainly low-end traditional products, such as cotton, gauze and other traditional medical dressings, which lack certain competitiveness in the high-end market. And it cannot meet the needs of different typ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F2/28D01F1/10D04H1/728D01D5/00A61L15/42A61L15/44A61L15/62A61L15/32A61L15/28
CPCA61L15/28A61L15/325A61L15/42A61L15/425A61L15/44A61L15/62A61L2300/23A61L2300/404D01D5/0015D01F1/10D01F2/28D04H1/728C08L1/12
Inventor 不公告发明人
Owner 杭州鹿扬科技有限公司
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