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Application of 8-hydroxyquinoline rare earth metal organic complex to preparation of anti-new coronavirus product and preparation method of 8-hydroxyquinoline rare earth metal organic complex

A technology of organic complexes and rare earth metals, applied in medical preparations containing active ingredients, antiviral agents, organic chemistry, etc. Simple, enhanced anti-viral effect, high-yield effect

Active Publication Date: 2021-02-05
BAOTOU RARE EARTH RES & DEV CENT CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is research on the synthesis of complexes of rare earth and quinoline derivatives, but the method of grinding and heating is used, the yield of the product obtained is low, and the process is complicated
And most of the structural characteristics of the product itself have been studied, and no detailed research has been done on its performance.
[0004] At present, the new crown pneumonia is raging around the world, and there is no specific product against the new coronavirus

Method used

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  • Application of 8-hydroxyquinoline rare earth metal organic complex to preparation of anti-new coronavirus product and preparation method of 8-hydroxyquinoline rare earth metal organic complex
  • Application of 8-hydroxyquinoline rare earth metal organic complex to preparation of anti-new coronavirus product and preparation method of 8-hydroxyquinoline rare earth metal organic complex
  • Application of 8-hydroxyquinoline rare earth metal organic complex to preparation of anti-new coronavirus product and preparation method of 8-hydroxyquinoline rare earth metal organic complex

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Utilize the reaction of cerium chloride and 8-hydroxyquinoline to synthesize organic complexes, wherein the synthesis reaction formula is as follows:

[0037]

[0038] The preparation method of above-mentioned 8-hydroxyquinoline cerium organic complex comprises the following steps:

[0039] (1) Add cerium trichloride heptahydrate (370mg, 1.0mmol) into a round bottom flask containing 15mL of deionized water to obtain a cerium chloride solution; 8-hydroxyquinoline (435mg, 3.0mmol) is added to the flask containing In the 25ml beaker of 10ml absolute ethanol solution, obtain 8-hydroxyquinoline solution;

[0040] (2) Drop the 8-hydroxyquinoline solution into the cerium chloride solution, wash the beaker with 5ml of absolute ethanol solution and add to the system, mix evenly, and react the mixture for 1-3 hours under the condition that the reaction temperature is room temperature. During the whole process, the ethanol solution of sodium hydroxide was used to adjust the pH...

Embodiment 2

[0043] Use lanthanum chloride to react with 8-hydroxyquinoline to synthesize organic complexes, wherein the synthesis reaction formula is as follows:

[0044]

[0045] The preparation method of above-mentioned 8-hydroxyquinoline lanthanum organic complex comprises the following steps:

[0046] (1) Heptahydrate lanthanum trichloride (3.71g, 10.0mmol) was added to a round bottom flask containing 75mL deionized water to obtain a lanthanum chloride solution, and 8-hydroxyquinoline (4.35g, 30.0mmol) was added to In the beaker that contains 65ml absolute ethanol solution, obtain 8-hydroxyquinoline solution;

[0047](2) Drop the 8-hydroxyquinoline solution into the lanthanum chloride solution, wash the beaker with 10ml of ethanol aqueous solution and add it to the system, mix well; the mixture reacts for 1-3 hours under the condition that the reaction temperature is room temperature; The sodium solution adjusts the pH within the range of 5-10. After the reaction is completed, the...

Embodiment 3

[0050] Utilize europium chloride to react with 8-hydroxyquinoline to synthesize an organic complex, wherein the synthesis reaction formula is as follows:

[0051]

[0052] The preparation method of above-mentioned 8-hydroxyquinoline europium organic complex comprises the following steps:

[0053] (1) Europium chloride hexahydrate (3.66g, 10.0mmol) was added to a round-bottomed flask containing 75mL of deionized water to obtain a europium chloride solution; 8-hydroxyquinoline (4.35g, 30.0mmol) was added In the beaker containing 65ml absolute ethanol solution, obtain 8-hydroxyquinoline solution;

[0054] (2) Drop the 8-hydroxyquinoline solution into the europium chloride solution, wash the beaker with 10 ml of ethanol aqueous solution and add to the system, and mix well. The mixture is reacted at room temperature for 1-3 hours. During the whole process, sodium hydroxide solution is used to adjust the pH within the range of 5-10. After the reaction is completed, the precipit...

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Abstract

The invention provides an application of an 8-hydroxyquinoline rare earth metal organic complex to an anti-new coronavirus (SARS-CoV-2) product and a preparation method of the 8-hydroxyquinoline rareearth metal organic complex. The 8-hydroxyquinoline rare earth metal organic complex takes one of rare earth metal elements cerium, lanthanum, praseodymium and europium as a central atom and 8-hydroxyquinoline as a ligand, wherein the central atom rare earth metal has physiological and biological activity, the ligand can form a coordination bond with a chemical group of an active part of the novelcoronavirus, after rare earth metal ions and 8-hydroxyquinoline form a complex, the antiviral effect can be improved, and the complex has a very high antiviral activity rate for the novel coronavirus. The 30s anti-new coronavirus activity rate of the organic complex provided by the invention reaches 99.55%, and the 1min anti-new coronavirus activity rate reaches 99.99%. The preparation method provided by the invention has the advantages of easily available raw materials, simple operations, mild reaction conditions and high yield.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to the application and preparation method of an 8-hydroxyquinoline rare earth metal organic complex in the preparation of anti-new coronavirus (SARS-CoV-2) products. Background technique [0002] Rare earth metals exist widely in nature, because of their unique 4f electron shell and nuclear structure, they not only have unique physiological and biological activities, but also have antibacterial and antiviral effects. In the prior art, a series of tests on the anti-influenza virus activity of inorganic rare earth heteropoly blue complexes have shown that rare earth metals have certain antiviral activity. However, its antiviral activity is not ideal and cannot meet people's requirements. Quinoline derivatives can form coordination bonds with chemical groups in key active parts of viruses, thereby changing their structures. Research in the prior art shows that N...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/555A61P31/14C07D215/30
CPCA61K31/555A61P31/14C07D215/30
Inventor 王沛葭张磊阳闫柏豪张朔池建义王乃兴
Owner BAOTOU RARE EARTH RES & DEV CENT CHINESE ACADEMY OF SCI
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