Saponin polyphenol compound as well as preparation method and application thereof

A compound and saponin technology, applied in the directions of hydroxy compound active ingredients, drug combinations, pharmaceutical formulations, etc., can solve problems such as limited general supportive treatment and symptomatic treatment, central nervous system damage, etc., to maintain the therapeutic effect, dilute psychological craving, The effect of prolonging the conduct time

Active Publication Date: 2021-01-29
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For the central nervous system damage (including addiction and memory damage) and cardiovascular system damage caused by amphetamine-type new drugs, there is currently no targeted specific drug in clinical practice, and the most common treatments are limited to general supportive care and symptomatic treatment

Method used

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  • Saponin polyphenol compound as well as preparation method and application thereof
  • Saponin polyphenol compound as well as preparation method and application thereof
  • Saponin polyphenol compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A saponin polyphenol complex, comprising the following components: American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol; the quality of the American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol The composition ratio is 3:1:4:2.

[0037] Protective application of a saponin-polyphenol complex in the central nervous system / cardiovascular system damage caused by amphetamine-like new drugs, an experiment on the protective effect on the formation of conditioned place preference (CPP) in methamphetamine-infected mice The method is:

[0038] S1. Randomly divide the animals to be tested into 5 groups, 10 in each group;

[0039] The experimental animals were C57 male mice with a weight of 18-22g. They were raised in a constant temperature and air-conditioned SPF grade animal room. They were subjected to a 12-hour cycle of light and dark, and kept drinking water and eating freely. The mice were randomly divided into 5 g...

Embodiment 2

[0047]A saponin polyphenol complex, comprising the following components: American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol; the quality of the American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol The composition ratio is 3:1:4:2.

[0048] The protective application of a saponin polyphenol compound in the central nervous system / cardiovascular system injury caused by amphetamine-type new drugs, the experimental method of the protective effect on the learning and memory impairment of methamphetamine-exposed mice is as follows:

[0049] S1. Randomly divide the animals to be tested into 5 groups, 10 in each group;

[0050] The experimental animals were C57 male mice with a body weight of 18-22 g. They were raised in a constant temperature and air-conditioned SPF grade animal room, with a 12-hour light and dark cycle, and free drinking water and food were kept. The mice were randomly divided into 5 groups, 10 in each g...

Embodiment 3

[0057] A saponin polyphenol complex, comprising the following components: American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol; the quality of the American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol The composition ratio is 3:1:4:2.

[0058] The protective application of a saponin polyphenol compound in the central nervous system / cardiovascular system injury caused by amphetamine-type new drugs, the experimental method of the protective effect on the cardiac function injury of rats exposed to methamphetamine is as follows:

[0059] S1. Randomly divide the animals to be tested into 5 groups, 10 in each group;

[0060] The experimental animals were Wistar male rats with a body weight of 180-220g. They were raised in a constant temperature and air-conditioned SPF grade animal room, with a 12-hour light and dark cycle, and kept drinking water and eating freely. The rats were randomly divided into 5 groups, 10 in each g...

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Abstract

The invention discloses a saponin polyphenol compound as well as a preparation method and application thereof, and belongs to the field of drug addiction treatment drugs. The saponin polyphenol compound is prepared from the following components: American ginseng saponin, fructus chebulae immaturus polyphenol, tea polyphenol and resveratrol, wherein the mass ratio of American ginseng saponin to fructus chebulae immaturus polyphenol to tea polyphenol to resveratrol is 3: 1: 4: 2; the traditional Chinese medicine composition can significantly reduce and fade psychological desire of addicts, reduces drug use of the addicts, has good maintenance and treatment effects, and can improve or prolong the guard time; the cognitive impairment of a patient addicted to methamphetamine is remarkably reduced; the left ventricular ejection fraction, the pulse volume and the cardiac discharge volume are remarkably increased, and the cardiac function condition of a patient is obviously improved; the safety is high, the use is convenient, the price is low, and the economic burden of patients can be reduced; the compound has specificity and can be used for comprehensively and effectively relieving the root causes of diseases.

Description

technical field [0001] The invention relates to the technical field of drugs for detoxification, in particular to a saponin-polyphenol compound and its preparation method and application. Background technique [0002] The biggest feature of new amphetamine drugs is strong addiction and high relapse rate. Another feature is that it can cause organic damage to vital organs of the human body, and even death. The main toxicity damage of new amphetamine drugs is It acts on the central nervous system and cardiovascular system, and the damage of these two systems is closely related to the death caused by abuse, which has gradually attracted the attention of researchers. [0003] On the one hand, long-term use of new amphetamine-type drugs can cause damage to multiple parts of the brain, such as the substantia nigra, striatum, hippocampus, and cortex, and cause pathological changes similar to degenerative neuropathies such as Alzheimer's disease and Parkinson's disease. Damage and ...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K36/82A61P25/28A61P9/00A61P25/36A61K31/353A61K31/05
CPCA61K36/258A61K36/185A61K36/82A61K31/353A61K31/05A61P25/28A61P9/00A61P25/36A61K2300/00
Inventor 陈琳茹琴周梅熊琪徐丛玥林款李超英徐国栋吴钰祥
Owner JIANGHAN UNIVERSITY
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