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A kind of saponin polyphenol compound and its preparation method and application

A compound and saponin technology, applied in the direction of active ingredients of hydroxy compounds, drug combinations, pharmaceutical formulations, etc., can solve the problems of central nervous system damage, limited general supportive treatment and symptomatic treatment, etc., to improve cardiac function and maintain the therapeutic effect. , the effect of reducing psychological craving

Active Publication Date: 2022-04-26
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For the central nervous system damage (including addiction and memory damage) and cardiovascular system damage caused by amphetamine-type new drugs, there is currently no targeted specific drug in clinical practice, and the most common treatments are limited to general supportive care and symptomatic treatment

Method used

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  • A kind of saponin polyphenol compound and its preparation method and application
  • A kind of saponin polyphenol compound and its preparation method and application
  • A kind of saponin polyphenol compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A saponin polyphenol complex, comprising the following components: American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol; the quality of the American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol The composition ratio is 3:1:4:2.

[0037] Protective application of a saponin-polyphenol complex in the central nervous system / cardiovascular system damage caused by amphetamine-like new drugs, an experiment on the protective effect on the formation of conditioned place preference (CPP) in methamphetamine-infected mice The method is:

[0038] S1. Randomly divide the animals to be tested into 5 groups, 10 in each group;

[0039] The experimental animals were C57 male mice with a weight of 18-22g. They were raised in a constant temperature and air-conditioned SPF grade animal room. They were subjected to a 12-hour cycle of light and dark, and kept drinking water and eating freely. The mice were randomly divided into 5 g...

Embodiment 2

[0047]A saponin polyphenol complex, comprising the following components: American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol; the quality of the American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol The composition ratio is 3:1:4:2.

[0048] The protective application of a saponin polyphenol compound in the central nervous system / cardiovascular system injury caused by amphetamine-type new drugs, the experimental method of the protective effect on the learning and memory impairment of methamphetamine-exposed mice is as follows:

[0049] S1. Randomly divide the animals to be tested into 5 groups, 10 in each group;

[0050] The experimental animals were C57 male mice with a body weight of 18-22 g. They were raised in a constant temperature and air-conditioned SPF grade animal room, with a 12-hour light and dark cycle, and free drinking water and food were kept. The mice were randomly divided into 5 groups, 10 in each g...

Embodiment 3

[0057] A saponin polyphenol complex, comprising the following components: American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol; the quality of the American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol The composition ratio is 3:1:4:2.

[0058] The protective application of a saponin polyphenol compound in the central nervous system / cardiovascular system injury caused by amphetamine-type new drugs, the experimental method of the protective effect on the cardiac function injury of rats exposed to methamphetamine is as follows:

[0059] S1. Randomly divide the animals to be tested into 5 groups, 10 in each group;

[0060] The experimental animals were Wistar male rats with a body weight of 180-220g. They were raised in a constant temperature and air-conditioned SPF grade animal room, with a 12-hour light and dark cycle, and kept drinking water and eating freely. The rats were randomly divided into 5 groups, 10 in each g...

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Abstract

The invention discloses a saponin-polyphenol compound, a preparation method and application thereof, and belongs to the field of drugs for detoxification. A saponin polyphenol complex, comprising the following components: American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol; the quality of the American ginseng saponins, green fruit polyphenols, tea polyphenols and resveratrol The composition ratio is 3:1:4:2; the present invention can significantly reduce and dilute the psychological craving effect of addicts, reduce the drug use of addicts, have a good maintenance treatment effect, and can improve or prolong the time of conduct; significantly reduce Cognitive function impairment in patients with methamphetamine addiction; significantly improved left ventricular ejection fraction, stroke volume, and cardiac output, and significantly improved the patient's cardiac function; high safety, easy to use, low price, and can reduce the patient's Economic burden: the present invention has specificity and can comprehensively and effectively alleviate the root cause of the disease.

Description

technical field [0001] The invention relates to the technical field of drugs for detoxification, in particular to a saponin-polyphenol compound and its preparation method and application. Background technique [0002] The biggest feature of new amphetamine drugs is strong addiction and high relapse rate. Another feature is that it can cause organic damage to vital organs of the human body, and even death. The main toxicity damage of new amphetamine drugs is It acts on the central nervous system and cardiovascular system, and the damage of these two systems is closely related to the death caused by abuse, which has gradually attracted the attention of researchers. [0003] On the one hand, long-term use of new amphetamine-type drugs can cause damage to multiple parts of the brain, such as the substantia nigra, striatum, hippocampus, and cortex, and cause pathological changes similar to degenerative neuropathies such as Alzheimer's disease and Parkinson's disease. Damage and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K36/82A61P25/28A61P9/00A61P25/36A61K31/353A61K31/05
CPCA61K36/258A61K36/185A61K36/82A61K31/353A61K31/05A61P25/28A61P9/00A61P25/36A61K2300/00
Inventor 陈琳茹琴周梅熊琪徐丛玥林款李超英徐国栋吴钰祥
Owner JIANGHAN UNIVERSITY
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