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Tubular tissue structure body and constructing method thereof

A construction method and structure technology, applied in the field of biomedical engineering, can solve problems such as low patency rate, customization and manufacturing, and difficulty

Pending Publication Date: 2021-01-12
REGENOVO BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In certain cardiovascular diseases, necrotic blood vessels sometimes need to be replaced and transplanted, but the artificial blood vessels currently used as surgical transplants still cannot perfectly meet the requirements of high biocompatibility, good mechanical properties, and the ability to contract and relax.
For example, artificial blood vessels with a diameter of less than 6 mm currently used for coronary vascular grafts still have a low patency problem. At the same time, it is difficult to customize and manufacture complex-shaped vascular structures at this stage

Method used

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  • Tubular tissue structure body and constructing method thereof
  • Tubular tissue structure body and constructing method thereof
  • Tubular tissue structure body and constructing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] Example 1 Construction of Fibrin Tubular Vasculoid Structure

[0109] 1. Preparation of printing platform

[0110] Construct a stainless steel alloy frame structure, and assemble the 3D printing nozzle and winding rod in the frame, debug the motor control system, and build a motion system to ensure that the 3D printing nozzle can perform translational motion and the winding rod can perform rotational motion. During the installation process, ensure that the 3D printing nozzle is placed directly above the winding rod and in the same vertical plane as the winding rod. The winding rod is placed horizontally, and its rotational movement can be precisely controlled, while the translational direction of the 3D printing nozzle is along the axis of the winding rod, and its movement can also be precisely controlled. The platform structural parts are all customized from the enterprise, and a few parts such as motor mounting boards are obtained by purchasing raw materials such as ...

Embodiment 2

[0132] Example 2 Construction of fibrin tubular bile duct-like structure

[0133] 1. Preparation of printing platform

[0134] Construct a stainless steel alloy frame structure printing platform, mainly including printing nozzles and winding units for tubular construction. Among them, the printing platform and its components are independently drawn and designed, and each component can be customized by the enterprise or processed by a professional machining unit.

[0135] In this embodiment, a microfluidic chip nozzle designed based on the principle of microfluidics is used, and PMMA material is used to construct a microfluidic chip nozzle with a Y+S configuration flow channel. The nozzle can effectively promote solution fusion and prevent channel blockage problems.

[0136] The diameter of the glass tube used for winding in this embodiment is about 0.5 cm, which is close to the diameter of the human bile duct.

[0137] 2. Printing ink (bioprinting material) preparation

[...

Embodiment 3

[0161] Example 3 Construction of Tubular Bronchoid Structure

[0162] 1. Preparation of printing platform

[0163] Construct a stainless steel alloy frame structure printing platform, mainly including printing nozzles and winding units for tubular construction. Among them, the printing platform and its components are independently drawn and designed, and each component can be customized by the enterprise or processed by a professional machining unit.

[0164] In this embodiment, a microfluidic chip nozzle designed based on the microfluidic principle is used, and a PMMA material is used to construct a microfluidic chip nozzle with a single flow channel. The spray head can precisely control the solution flow.

[0165] The diameter of the glass tube used for winding in this embodiment is about 1 cm, which is similar to the diameter of the human bronchus.

[0166] 2. Printing ink (bioprinting material) preparation

[0167] The printing ink of the present invention can be purch...

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Abstract

The invention provides a tubular tissue structure body and a constructing method thereof. The method comprises the following steps: A, preparing printing ink; B, culturing cells for printing in vitroto obtain a cell culture solution; and C, respectively connecting the printing ink and the cell culture solution with different spray heads of a biological printer, jointly printing the printing ink and the cell culture solution on a winding rod to form seamless tubular tissue, and then removing the winding rod to obtain the hollow tubular tissue structure body. According to the method, a tubularstructure with a controllable structure and cell / material components is formed through a horizontal winding type cell 3D printing technology. The tubular structure is close to a human vessel in shapeand size, has mechanical and biological properties meeting the requirements of a human body, has clinical application potential, and can be applied to the aspects of drug detection, tissue engineering, regenerative medicine, in-vitro physiological model / pathological model / pharmacological model construction, tissue / organ / human body chips and the like.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a tubular tissue-like structure and a construction method thereof. Background technique [0002] The human vascular system is widely distributed, providing the transportation of nutrients, oxygen and hormones to various organs in the human body, and playing an important role in the growth and development of tissues and organs throughout the body and maintaining their functions. [0003] The cardiovascular system exchanges nutrients and oxygen for various organs in the human body. In certain cardiovascular diseases, necrotic blood vessels sometimes need to be replaced and transplanted, but the artificial blood vessels currently used as surgical transplants still cannot perfectly meet the requirements of high biocompatibility, good mechanical properties, and systolic and diastolic capabilities. For example, artificial blood vessels with a diameter of less than 6 mm currently ...

Claims

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Application Information

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IPC IPC(8): A61F2/04
CPCA61F2/04A61F2240/002
Inventor 姚睿徐铭恩
Owner REGENOVO BIOTECH
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