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Implantation method of deep flexible brain electrodes combined with drug delivery

A brain electrode and flexible technology, applied in the field of brain function detection, can solve the problems that the electrode probe cannot obtain nerve signals, cannot be rigidly implanted in brain tissue, and has low Young's modulus, so as to inhibit infection and postoperative inflammatory response, Good biocompatibility and minimal invasiveness, high implantation success rate

Active Publication Date: 2022-04-26
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the mechanical properties of flexible electrodes are close to those of brain tissue, and have extremely low Young's modulus, they cannot be implanted into brain tissue by virtue of their own stiffness.
Currently widely used auxiliary implantation methods include freeze hardening, shuttle device assistance, etc. These auxiliary methods often cause additional tissue damage during implantation, which in turn makes it take longer for the nerve tissue to recover, and the electrode probe cannot be recovered after surgery. first neural signal

Method used

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  • Implantation method of deep flexible brain electrodes combined with drug delivery
  • Implantation method of deep flexible brain electrodes combined with drug delivery
  • Implantation method of deep flexible brain electrodes combined with drug delivery

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Embodiment

[0038] In order to solve the problem that the flexible brain electrode cannot be implanted into the brain tissue by virtue of its own rigidity, and the existing auxiliary implantation methods will cause additional tissue damage during implantation, infection and postoperative inflammation during the operation, this embodiment An implantation method of a deep flexible brain electrode combined with drug delivery is provided. The implantation method of a deep flexible brain electrode combined with drug delivery in this embodiment includes a flexible brain electrode pretreatment step and a flexible brain electrode implantation step, The pretreatment step of the flexible brain electrode specifically includes: forming a solidified protein protection layer on the surface of the flexible brain electrode, wherein the protein protection layer includes the drug to be delivered. The implantation method of the deep flexible brain electrode in this embodiment forms a layer of solidified prot...

Embodiment approach

[0039] In this embodiment, a solidified protein protective layer is formed on the surface of the flexible brain electrode through the preparation of the concentrated protein solution, the preparation of the protein-drug mixed solution, the dip coating of the brain electrode and the vacuum treatment steps, as a specific implementation mode , the preparation method of concentrated protein solution comprises the following steps:

[0040] Natural silkworm cocoons are exposed to Na at a concentration of 0.02±0.001m 2 CO 3 After boiling in an aqueous solution for 55-65 minutes, rinse the natural cocoons with distilled water for 2-5 times, each time for 25-35 minutes, to remove Na 2 CO 3and sericin; dry the degummed natural silkworm cocoon for more than 12 hours, then dissolve it in a LiBr solution with a concentration of 9.3±0.5m, and then dry it at 60±3°C for 2-6 hours to obtain a silk protein solution, and fill the silk protein solution with Put it into a dialysis bag, dialyze ...

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Abstract

The invention discloses an implantation method of a deep flexible brain electrode combined with drug delivery. The implantation method includes a flexible brain electrode pretreatment step and a flexible brain electrode implantation step. The flexible brain electrode pretreatment step specifically includes: A cured protein protective layer is formed on the surface of the flexible brain electrode, wherein the cured protein protective layer includes drugs to be delivered. The present invention forms a solidified protein protective layer on the surface of the flexible brain electrode, and its Young's modulus can be raised enough to be implanted in the brain, and has good biocompatibility and minimal invasiveness; Containing a certain concentration of the drug to be delivered can effectively inhibit intraoperative infection and postoperative inflammatory response; the implantation operation of the flexible brain electrode of the present invention is relatively convenient and simple, and the implantation success rate is high.

Description

technical field [0001] The invention relates to the technical field of brain function detection, in particular to a method for implanting deep flexible brain electrodes combined with drug delivery. Background technique [0002] Implantable neural probes are the most widespread tool for recording neural activity at single-cell, sub-millisecond resolution, but signals from implantable neural probes tend to fade due to chronic inflammatory responses and neuronal cell deactivation around the implantation site. degrades over time. The failure to implant neural probes for long-term recording is one of the most critical challenges in longitudinal studies of cognitive functions (such as learning and memory) and in high-fidelity neural prosthetics. [0003] Experimental evidence suggests that flexible neural probes with mechanical strength close to that of brain tissue can reduce relative shear motion, thereby improving the stability of electrode recordings and their working lifetim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/293A61M31/00
CPCA61B5/6846A61M31/00A61B2562/16A61M2210/0693A61M2210/005
Inventor 陶虎周渝周志涛魏晓玲
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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