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Use of ethyl lauroylarginate and derivatives thereof as antiviral agents

A technology of lauroyl arginine ethyl ester and antiviral agent, applied in the application field of lauroyl arginine ethyl ester and derivatives thereof as antiviral agent, can solve the problem of not studying the independent antiviral effect of LAE, not teaching etc. problem, to achieve the effect of obvious anti-vesicular stomatitis virus activity

Pending Publication Date: 2020-12-22
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method involves a variety of cationic compound disinfectant components including LAE, and the independent antiviral effect of LAE has not been studied
Simultaneously, this invention only teaches the purposes such as described composition is used in object surface disinfection and space disinfection or sterilization, does not teach how to use single LAE composition for the purposes of antiviral agent

Method used

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  • Use of ethyl lauroylarginate and derivatives thereof as antiviral agents
  • Use of ethyl lauroylarginate and derivatives thereof as antiviral agents
  • Use of ethyl lauroylarginate and derivatives thereof as antiviral agents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: The preparation method of the ion-pair compound synthesized by lauroyl arginine ethyl ester hydrochloride and nicotinic acid

[0046] Dissolve 2.0 g of sodium nicotinate (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) in 50 mL of water to prepare sodium nicotinic acid salt solution (A); dilute 6.8 g of ethyl lauroyl arginate hydrochloride Dissolve in 40mL of water, heat to 90°C until ethyl lauroyl arginine hydrochloride is completely dissolved to make ethyl lauroyl arginine hydrochloride aqueous solution (B); Slowly add the saline solution (A) into the aqueous solution of lauroyl arginine ethyl ester hydrochloride (B), stir continuously, react for 2 hours, cool to room temperature, filter, wash the precipitate fully with pure water, and dry the precipitate under vacuum at 60°C. That is, 7.6 g of the nicotinic acid ion pair compound was obtained.

Embodiment 2

[0047] Embodiment two lauroyl arginine ethyl ester nicotinic acid ion pair compound molecular formula, the analysis of molecular weight

[0048] by mass spectrometry, 1 H-NMR, 13 The molecular formula of the compound obtained by C-NMR spectral analysis is:

[0049] 1. Mass spectrometry (ESI) analysis

[0050] Cation B + Molecular ion peak at m / z=385.3, see figure 1 ;

[0051] The ESI+ detected by mass spectrometry is 124.2, see figure 2 . Then ESI- is 122.2, that is, the m / z of the anion A-molecular ion peak is 122.2. The theoretically calculated value of the cation in the nicotinic acid ion-pair compound is 507.4, and the measured value is consistent with the theoretical value.

[0052] 2. NMR analysis

[0053] Ethyl lauroyl arginate hydrochloride (see image 3 ), niacin 1 H-NMR (see Figure 4 ) and LAE nicotinic acid ion pair compound 1 H-NMR (see Figure 5 )Compared. Since the LAE ion-pair compound has little change in the peak shape and chemical shift of la...

Embodiment 3

[0054] Example 3: Preparation method of ethyl lauroyl arginine hydrochloride and tartaric acid synthetic ion pair compound

[0055] Dissolve 2.0 g of tartaric acid (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) in 50 mL of methanol, add an equivalent amount of NaOH, stir at room temperature until a white solid precipitates, filter with suction and wash three times with 30 mL of methanol to obtain sodium tartrate . Sodium tartrate was dissolved in 50mL of water to prepare sodium tartrate aqueous solution (A); 5.6g of ethyl lauroyl arginine hydrochloride was dissolved in 40mL of water, heated to 90°C until ethyl lauroyl arginine The acid salt was completely dissolved to make ethyl lauroyl arginine hydrochloride aqueous solution (B); at 90°C, sodium tartrate aqueous solution (A) was slowly added to ethyl lauroyl arginine hydrochloride aqueous solution ( In B), stir continuously, react for 2 hours, cool to room temperature, filter, wash the precipitate wi...

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PUM

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Abstract

The invention discloses an antiviral agent. The antiviral agent comprises a condensate derived from a fatty acid and an esterified binary amino acid, can act on Newcastle disease virus and vesicular stomatitis virus in vitro, and reduce infection of cells by the Newcastle disease virus and vesicular stomatitis virus. The antiviral agent is added to cultured Newcastle disease virus (NDV) and vesicular stomatitis virus (VSV), or the antiviral agent is added at different times before and after infection of cells by the viruses, the infected cells are detected, and it is found that number of viruses is obviously reduced. The antiviral agent can effectively inhibit or kill viruses and can be used for preventing or reducing infection capacity of viruses to cells.

Description

technical field [0001] The invention relates to the application of the compound lauroyl arginine ethyl ester and its derivatives in the preparation of antiviral agents. Background technique [0002] Newcastle disease is an acute, febrile, septic and highly contagious infectious disease of poultry caused by Newcastle disease virus (NDV), characterized by high fever, dyspnea, diarrhea, nervous disorders, mucosal and serosal hemorrhage, The morbidity and mortality rate can reach more than 90%. It is a major infectious disease that endangers the poultry industry. It is listed as a first-class animal disease by the Ministry of Agriculture of my country. The susceptibility of Newcastle disease is relatively strong, and the possibility of onset occurs in all seasons, among which the incidence rate is higher in autumn, winter and early spring, and all kinds of poultry can be infected, among which geese and ducks have a higher incidence rate; at the same time, sick birds are the sourc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61P1/02
CPCA61K31/155A61P1/02
Inventor 易正芳高嵩邵婷仇文卫刘明耀
Owner EAST CHINA NORMAL UNIV
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