Polyvinyl alcohol-pectin embolism microsphere, drug-loaded embolism microsphere and preparation method

Abstract

The invention discloses a polyvinyl alcohol-pectin embolism microsphere, a drug-loaded embolism microsphere and a preparation method. A preparation method of the embolism microsphere comprises the following steps: blending a polyvinyl alcohol solution and a pectin solution to obtain a water phase; dissolving an emulsifier in a continuous phase, and performing uniform mixing to obtain an oil phase;adding the water phase into the oil phase, and performing uniform stirring to obtain polyvinyl alcohol-pectin emulsion; dissolving a cross-linking agent namely glutaraldehyde and a catalyst namely hydrochloric acid in diethyl ether to obtain a mixture, dropwise adding the mixture into the polyvinyl alcohol-pectin emulsion, and performing a cross-linking reaction to obtain a polyvinyl alcohol-pectin suspension; and centrifuging and washing the polyvinyl alcohol-pectin suspension, and then performing freeze-drying to obtain the polyvinyl alcohol-pectin embolism microsphere. The preparation method comprises the steps of dissolving anti-tumor drug in water to obtain an anti-tumor drug solution, then placing the polyvinyl alcohol-pectin microsphere into the anti-tumor drug solution, performingstirring, and enabling the polyvinyl alcohol-pectin embolism microsphere to adsorb the anti-tumor drug to obtain the polyvinyl alcohol-pectin drug-loaded embolism microsphere. The prepared embolism microsphere has certain degradation capacity and higher drug loading capacity.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and polymer materials, and specifically relates to a polyvinyl alcohol-pectin embolic microsphere, a drug-loaded embolic microsphere and a preparation method. Background technique [0002] In interventional therapy technology, transcatheter vascular embolization (TACE) is a very important treatment method, which mainly injects embolic agents into the supply vessels of diseased target organs through arterial or intravenous catheters, so as to occlude the blood vessels and interrupt the blood vessels. blood supply, and ultimately achieve therapeutic purposes. [0003] When using TACE technology to treat tumors, in addition to blocking blood vessels, chemotherapy drugs will also be injected into the tumor, which can not only block the blood supply of the tumor, make the tumor lack the necessary nutrients, but also strengthen the lethality of the drug on the tumor and reduce the risk of drug loss....

AI Technical Summary

Problems solved by technology

[0004] Traditional TACE commonly uses lipiodol-chemotherapy mixed emulsion for embolization, but there are several major defects: ① lipiodol emulsion will have local deposition, and as time goes on, the cytotoxic effect of the drug on the tumor will also decrease; ② although the emulsion is more traditional Chemotherapy reduces systemic adverse reactions, but some drugs still enter the circulatory system, increasing adverse reactions; ③In tumor treatment, the therapeutic effect requires maintaining a certain drug concentration inside the tumor, which depends on the sustained release of drugs, and lipiodol emulsion is difficult do it

At present, there are polyvinyl alcohol embolization microspheres on the market, but the polyvinyl alcohol embolization microspheres hardly degrade in the body. At the same time, the polyvinyl alcohol embolization microspheres themselves do not contain active groups. Activation or re-derivatization of microspheres is complicated, and the drug loading of polyvinyl alcohol embolization microspheres is still low

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