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Method for extracting quebrachitol from artemisia plants

A technology of quercetinol and artemisia plant, which is applied in the field of chemical substance preparation, can solve the problems such as no preparation of quercetinol, and achieves the effects of being easy to enlarge, environmentally friendly in the preparation process, and safe in operation

Active Publication Date: 2020-11-03
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no process for preparing quebranol from Artemisia plants

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for extracting quebranol from dried leaves of Artemisia annua, taking 10kg of dried leaves of Artemisia annua and crushing, adding 10 times the amount of solvent and 85% ethanol aqueous solution to mix, and refluxing at 85°C Extract for 2 hours, extract twice, combine the two extracts, concentrate the extract to obtain 831g of Artemisia annua crude extract, add 1L of purified water to the crude extract to dissolve, filter, collect the filtrate, concentrate and dry to obtain 207g of Artemisia annua Baijian Bark alcohol extract, the content of quay quaica bark alcohol is 68.7%, add 2L of ethanol aqueous solution with a volume fraction of 50% at 70°C to dissolve it, keep it warm for 10 minutes, crystallize at 4°C, collect the crystals, and store them at 70°C Add 600mL of 50% ethanol aqueous solution under the condition to dissolve it, keep it warm for 10min, and crystallize at 4°C to obtain 81g of Quaia cortex alcohol crystals with a content of 99.7%.

Embodiment 2

[0028] A method for extracting Quina cortisol from the dried leaves of Artemisia annua, taking 10kg dried leaves of Artemisia annua and crushing them, adding the solvent with 10 times the amount of absolute ethanol and mixing them, refluxing and extracting at 85°C for 2 hours, and extracting three times, Merge the three extracts, concentrate the extract to obtain 541g of Artemisia annua crude extract, add 1L of purified water to the crude extract to dissolve, filter, collect the filtrate, concentrate and dry to obtain 132g of Artemisia annua Alcoholic Extract of Radix Cortex, Radix Cortex Cortex The alcohol content is 76.9%, add 2L ethanol aqueous solution with a volume fraction of 70% at 70°C to dissolve it, keep warm for 10 minutes, crystallize at 4°C, collect the crystals, add 600mL of ethanol with a volume fraction of 70% at 70°C % ethanol aqueous solution to dissolve it, and after keeping it warm for 10 minutes, crystallize at 4° C. to obtain 77 g of Quaia cortisol crystal...

Embodiment 3

[0030] A method for extracting quebranol from the dried leaves of Artemisia capillarye, taking 10kg of dried leaves of Artemisia capillarye and crushing them, adding solvent times of 10 times the volume fraction and 50% ethanol, and refluxing extraction under the condition of 85°C 2h, extracted three times, combined the three extracts, concentrated the extracts to obtain 997g of Artemisia annua crude extract, added 1L of purified water to the crude extract to dissolve, filtered, collected the filtrate, concentrated and dried to obtain 256g of Quaia quinquefolium of Artemisia annua Extract, the content of quebracho cortex is 67.7%, add 2L of ethanol aqueous solution with a volume fraction of 70% at 70°C to dissolve it, keep it warm for 10 minutes, crystallize at 4°C, collect the crystals, and store at 70°C Add 600mL of 70% ethanol aqueous solution to dissolve it, keep it warm for 10min, and crystallize at 4°C to obtain 103g of Quaia cortisol crystals with a content of 98.7%.

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PUM

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Abstract

The invention discloses a method for extracting quebrachitol from artemisia plants, which comprises the following steps: extracting artemisia plant medicinal materials for 1-3 times by using a solvent, extracting for 0.2-3 hours each time, merging the extracting solutions, and concentrating the extracting solutions under reduced pressure to obtain a crude extract; wherein the raw material sourcescomprise artemisia capillaries, artemisia annua, artemisia carvifolia, artemisia argyi and other artemisia plants. The invention provides a cheap and easily available source approach is provided for preparation of quebrachitol related drugs; meanwhile, the method comprises the steps of alcohol solution extraction, water washing purification and crystallization, and quebrachitol with the content larger than 98.0% can be prepared.

Description

technical field [0001] The invention relates to the technical field of chemical substance preparation, in particular to a method for extracting quebranol from Artemisia plants. Background technique [0002] Inositol, also known as cyclohexyl alcohol, inositol, and hexahydroxycyclohexane, widely exists in nature and is related to protein synthesis, carbon dioxide fixation, and amino acid transfer in animals and plants. Inositol can also promote fat metabolism in the liver and other tissues, prevent fat accumulation in the liver, and lower blood cholesterol. It is clinically used to treat fatty liver, liver cirrhosis, arteriosclerosis and hyperlipidemia. Inositol theoretically has 9 possible isomers, most of which can form methyl ether. Inositol methyl ether is a monomethyl or diradical derivative of inositol, and correspondingly has many isomers. Inositol methyl ether can affect the physiological processes in animals, including hypoglycemic, anti-inflammatory and anti-tumor...

Claims

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Application Information

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IPC IPC(8): C07C43/196C07C41/34C07C41/36
CPCC07C41/34C07C41/36C07C2601/14C07B2200/07C07C43/196
Inventor 李名洁张继斌李昌瑜石卫标陈志元孙代华
Owner 劲牌持正堂药业有限公司
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