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Live vaccine for preventing viral infectious diseases

A live vaccine and viral technology, applied in the direction of viruses, vaccines, antiviral agents, etc., can solve the problems of limited serum sources, and achieve the effects of overcoming the limited serum sources, low production costs, and good immune effects

Pending Publication Date: 2020-10-30
陈继明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this type of vaccine is that the sources of human or animal sera that provide the corresponding antibodies are limited, and other causative pathogens may also be present in these sera

Method used

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  • Live vaccine for preventing viral infectious diseases

Examples

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Effect test

Embodiment 1

[0026] Example 1 illustrates the preparation method and application method of a live vaccine to prevent Newcastle disease virus. Example 1 illustrates the specific application of the present invention. This embodiment is not used to limit the application scope of the present invention and the protection scope of the patent of the present invention.

[0027] The preparation of the live vaccine described in Example 1 includes the following five steps. First, through molecular epidemiological investigation, it is determined that a certain strain of Newcastle disease virus is very similar to the local Newcastle disease virus epidemic strain and does not contain other known animal viruses, so it is determined as a vaccine seed virus; second, Inoculate a large number of chicken embryos with vaccine seed viruses to prepare ancestral seed viruses, and pack them into 10,000 pieces, each containing at least 10 million live viruses and half the infection of chicken embryos, and store them ...

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Abstract

The invention belongs to the technical field of biological medicines. The invention discloses a live vaccine for preventing viral infectious diseases. The live vaccine contains live viruses, the liveviruses in the live vaccine are combined with monoclonal antibodies, and the pathogenicity of the live viruses in the live vaccine is inhibited by means of the neutralizing effect of the monoclonal antibodies. Along with the rapid development of a monoclonal antibody technology, the live vaccine is prepared on the basis of an immune complex formed by a live virus and a neutralizing monoclonal antibody. The vaccine has the advantages of being rapid in vaccine seed virus preparation, high in safety, good in immune protection effect, suitable for preventing various viral infectious diseases, freeof preparing a large amount of human or animal serum containing neutralizing antibodies and the like, and the virulence of vaccine viruses is not worried to be enhanced.

Description

Technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the development, production and application of live vaccines for the prevention of viral infectious diseases, and can be used for the prevention of viral infectious diseases caused by influenza and other viruses. Background technique [0002] Influenza virus, respiratory syncytial virus, Newcastle disease virus, coronavirus and other viruses can cause viral infectious diseases in humans and animals. Viral infectious diseases seriously endanger the health and life safety of humans and various animals. Vaccines are an important substance to prevent viral infectious diseases. There are many types of vaccines for the prevention of viral infectious diseases that have been approved for use or are being studied, including whole virus inactivated vaccines, whole virus live vaccines, genetically engineered virus protein vaccines, DNA vaccines encoding virus proteins, and virus protein encod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12A61K39/145A61K39/155A61K39/215A61K39/17A61K39/385A61P31/12A61P31/16A61P31/14
CPCA61K39/12A61K39/385A61P31/12A61P31/16A61P31/14A61K2039/5258A61K2039/575A61K2039/5154A61K2039/70A61K2039/6056A61K2039/552C12N2760/16034C12N2760/18034C12N2760/18134C12N2770/20034C12N2770/16034
Inventor 陈继明
Owner 陈继明
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