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Scaffold material as well as preparation method and application thereof

A stent material and reaction technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as time-consuming, destruction, and limited promotion.

Active Publication Date: 2020-10-23
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can effectively form a high-strength hydrogel, it can destroy some proteins or light-sensitive drug activities through ultraviolet light cross-linking, so there are many limitations in this cross-linking method
In addition, the formation of the gel takes time and is inconvenient to store. It is not easy for surgeons to grasp it, which also limits the promotion of such materials to clinical applications.

Method used

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  • Scaffold material as well as preparation method and application thereof
  • Scaffold material as well as preparation method and application thereof
  • Scaffold material as well as preparation method and application thereof

Examples

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preparation example Construction

[0049] The present invention also provides a method for preparing the scaffold material, comprising: S) reacting multi-arm amino polyethylene glycol and polyaldehyde dextran in an aqueous solution to obtain the scaffold material.

[0050] Among them, the present invention has no special limitation on the sources of all raw materials, which are commercially available; the multi-arm amino polyethylene glycol and polyaldehyde dextran are the same as those described above, and will not be repeated here.

[0051] In the present invention, it is preferred to mix and react the multi-arm amino polyethylene glycol aqueous solution with the polyaldehyde dextran aqueous solution; the concentration of the multi-arm amino polyethylene glycol in the multi-arm amino polyethylene glycol aqueous solution is preferably 1 mg / mL~300mg / mL, more preferably 10mg / mL~250mg / mL, more preferably 30mg / mL~220mg / mL, most preferably 50mg / mL~200mg / mL; in some embodiments provided by the present invention, the...

Embodiment 1

[0064] Dissolve 20g (0.50mmol) of dextran (DEX, with a molecular weight of 40000Da) in 300mL of water, stir and dissolve, add 8.6g (0.15mmol solution) of sodium periodate, seal, and at a temperature of 25°C, The reaction was stirred for 24h. After the reaction, dialyze with deionized water for 3 days and freeze-dry to obtain polyaldehyde dextran with the structure of formula (IV).

[0065] The polyaldehyde dextran obtained in embodiment 1 is analyzed by nuclear magnetic resonance, and the hydrogen nuclear magnetic resonance spectrum is obtained, such as figure 1 mentioned. figure 1 For the obtained polyaldehyde dextran 1 H NMR chart.

Embodiment 2

[0067] Preparation of blank gel scaffold material

[0068] 4-arm PEG-NH with a molecular weight of 10000 2 and the polyaldehyde dextran (ODEX) obtained in Example 1 were respectively dissolved in PBS (pH=7.4), and the concentration of both was 100 mg / mL. Then add 250 μL of 4-arm PEG-NH 2 The solution was mixed with 250 μL of ODEX solution (PEG-NH 2 The mass ratio to ODEX was 1:1), after vortexing for 10 s, the mixture was placed in a mold to obtain a blank gel scaffold material.

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Abstract

The invention provides a scaffold material. The scaffold material is obtained by cross-linking multi-arm amino polyethylene glycol and multi-aldehyde glucan. Compared with the prior art, according tothe scaffold material provided by the invention, a cross-linked grid is formed through the Schiff base effect of aldehyde groups and amino groups; and when a medicine is carried, the medicine can be packaged in a scaffold, and the aldehyde groups rich in the material can be coupled with the amino-containing medicine. Therefore, the medicine is effectively retained in the cross-linked grid; furthermore, the medicine can be locally and slowly released at the focus part, and the problems of quick in-vivo metabolism and low utilization rate of the medicine are effectively solved. The scaffold material has wide development prospects in the application aspects of maintaining in-vivo drug concentration, reducing administration dosage, improving drug utilization rate, avoiding drug resistance andthe like. The scaffold material is simple and mild in preparation, free of selectivity for supported drug types, wide in application range and good in biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of sustained-release preparations, and in particular relates to a scaffold material, its preparation method and application. Background technique [0002] Surgical resection of tumors is still the first choice for tumor treatment, however, postoperative recurrence and metastasis have become the key issues restricting the success of surgical treatment. Taking colon cancer as an example, the 5-year survival rate of colon cancer detected early is as high as 85% when it is completely resected, while the 5-year survival rate of advanced colon cancer drops sharply to 17%. An important reason behind this is that the middle and advanced colon cancer tumors infiltrate extensively, the surgical resection is not clean, or the metastasis has already occurred during the operation. In addition, peritoneal metastases formed after some tumors such as advanced ovarian cancer and colon cancer invade the abdominal cavity grow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K47/36A61K31/704A61P35/00C08J3/24C08L71/02C08L5/02
CPCA61K9/19A61K47/36A61K31/704A61P35/00C08J3/246C08J2371/02C08J2405/02C08J2305/02C08J2471/02
Inventor 宋万通司星辉吉国锋马胜徐玉笛张瑜汤朝晖陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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