Preparation method of difunctional slow-release supramolecular hydrogel for injection
A supramolecular hydrogel, slow-release technology, applied to non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effect of ensuring safety, easy preparation, and simple ingredients
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Embodiment 1
[0036] This embodiment provides a method for preparing a bifunctional supramolecular hydrogel, comprising the following steps:
[0037] Step 1: Weigh 10 g of Scutellaria baicalensis root, crush it, add 40 mL of ethanol, process it ultrasonically, collect the filtrate after filtration, repeat the extraction 4 times, and then concentrate under reduced pressure to 50 mL to obtain the Scutellaria baicalensis extract;
[0038] Step 2: Weigh the LBA and add ethanol to obtain a 30mg / ml stock solution;
[0039] Step 3: Mix 100 μL LBA high-concentration stock solution and Scutellaria baicalensis extract (200 μL) evenly, and then add 7 times the volume of deionized water;
[0040] Step 4: After standing still, supramolecular hydrogel can be obtained, such as figure 1 As shown in A. The obtained gel is stable and can load the added traditional Chinese medicine extract. antibacterial activity such as figure 1 As shown in C, the free radical scavenging activity is as follows figure 2...
Embodiment 2
[0042] A method for preparing a bifunctional supramolecular hydrogel, comprising the following steps:
[0043] Step 1: Weigh 10 g of Scutellaria baicalensis root, crush it, add 40 mL of ethanol, process it ultrasonically, collect the filtrate after filtration, repeat the extraction 4 times, and then concentrate under reduced pressure to 50 mL to obtain the Scutellaria baicalensis extract;
[0044] Step 2: Weigh the LBA and add ethanol to obtain a 30mg / ml stock solution;
[0045] Step 3: Mix 100 μL LBA high-concentration stock solution and Scutellaria baicalensis extract evenly (230 μL), then add 7 times the volume of deionized water;
[0046] Step 4: After standing still, such as figure 1 A can obtain supramolecular hydrogel, which has free radical scavenging activity ( figure 2 ), long-term release function ( image 3 ).
Embodiment 3
[0048] A method for preparing a bifunctional supramolecular hydrogel, comprising the following steps:
[0049] Step 1: Weigh 10 g of Scutellaria baicalensis root, crush it, add 40 mL of ethanol, process it ultrasonically, collect the filtrate after filtration, repeat the extraction 4 times, and then concentrate under reduced pressure to 50 mL to obtain the Scutellaria baicalensis extract;
[0050] Step 2: Weigh the LBA and add ethanol to obtain a 30mg / ml stock solution;
[0051] Step 3: Mix 100 μL LBA high-concentration stock solution and Scutellaria baicalensis extract (250 μL) evenly, and then add 7 times the volume of deionized water;
[0052] Step 4: After standing still, such as figure 1 A can obtain supramolecular hydrogel, which has antibacterial (figure 1 C), free radical scavenging activity ( figure 2 ), long-term release function ( image 3 ).
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Abstract
Description
Claims
Application Information
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