Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of difunctional slow-release supramolecular hydrogel for injection

A supramolecular hydrogel, slow-release technology, applied to non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effect of ensuring safety, easy preparation, and simple ingredients

Pending Publication Date: 2022-05-06
SHANGHAI JIAO TONG UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, there are no studies on supramolecular hydrogels for multi-component co-delivery of TCM

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of difunctional slow-release supramolecular hydrogel for injection
  • Preparation method of difunctional slow-release supramolecular hydrogel for injection
  • Preparation method of difunctional slow-release supramolecular hydrogel for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This embodiment provides a method for preparing a bifunctional supramolecular hydrogel, comprising the following steps:

[0037] Step 1: Weigh 10 g of Scutellaria baicalensis root, crush it, add 40 mL of ethanol, process it ultrasonically, collect the filtrate after filtration, repeat the extraction 4 times, and then concentrate under reduced pressure to 50 mL to obtain the Scutellaria baicalensis extract;

[0038] Step 2: Weigh the LBA and add ethanol to obtain a 30mg / ml stock solution;

[0039] Step 3: Mix 100 μL LBA high-concentration stock solution and Scutellaria baicalensis extract (200 μL) evenly, and then add 7 times the volume of deionized water;

[0040] Step 4: After standing still, supramolecular hydrogel can be obtained, such as figure 1 As shown in A. The obtained gel is stable and can load the added traditional Chinese medicine extract. antibacterial activity such as figure 1 As shown in C, the free radical scavenging activity is as follows figure 2...

Embodiment 2

[0042] A method for preparing a bifunctional supramolecular hydrogel, comprising the following steps:

[0043] Step 1: Weigh 10 g of Scutellaria baicalensis root, crush it, add 40 mL of ethanol, process it ultrasonically, collect the filtrate after filtration, repeat the extraction 4 times, and then concentrate under reduced pressure to 50 mL to obtain the Scutellaria baicalensis extract;

[0044] Step 2: Weigh the LBA and add ethanol to obtain a 30mg / ml stock solution;

[0045] Step 3: Mix 100 μL LBA high-concentration stock solution and Scutellaria baicalensis extract evenly (230 μL), then add 7 times the volume of deionized water;

[0046] Step 4: After standing still, such as figure 1 A can obtain supramolecular hydrogel, which has free radical scavenging activity ( figure 2 ), long-term release function ( image 3 ).

Embodiment 3

[0048] A method for preparing a bifunctional supramolecular hydrogel, comprising the following steps:

[0049] Step 1: Weigh 10 g of Scutellaria baicalensis root, crush it, add 40 mL of ethanol, process it ultrasonically, collect the filtrate after filtration, repeat the extraction 4 times, and then concentrate under reduced pressure to 50 mL to obtain the Scutellaria baicalensis extract;

[0050] Step 2: Weigh the LBA and add ethanol to obtain a 30mg / ml stock solution;

[0051] Step 3: Mix 100 μL LBA high-concentration stock solution and Scutellaria baicalensis extract (250 μL) evenly, and then add 7 times the volume of deionized water;

[0052] Step 4: After standing still, such as figure 1 A can obtain supramolecular hydrogel, which has antibacterial (figure 1 C), free radical scavenging activity ( figure 2 ), long-term release function ( image 3 ).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of difunctional slow-release supramolecular hydrogel for injection, which comprises the following steps: step 1, taking radix scutellariae roots, adding ethanol, and extracting under an ultrasonic condition to obtain a radix scutellariae extract; 2, dissolving the chiral gel factor LBA with ethanol to prepare a high-concentration stock solution; step 3, uniformly mixing the radix scutellariae extract with chiral gelators with different concentrations; and step 3, adding deionized water into the mixed solution, and standing to form gel. The chiral supramolecular hydrogel is used as a gelling agent, the radix scutellariae extract is used as a functional substance, the gelling agent and small molecules in the radix scutellariae extract are subjected to non-covalent bond interaction to generate the chiral supramolecular hydrogel, other organic solvents, stabilizers and other substances do not need to be added in the preparation process, the preparation process is simple, mild, green, safe and non-toxic, and the safety of operators is guaranteed.

Description

technical field [0001] The invention relates to the technical field of material preparation, in particular to a method for preparing a bifunctional slow-release supramolecular hydrogel that can be used for injection. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic non-specific disease with unknown pathogenesis mainly involving the intestinal tract. In recent years, the number of IBD patients in my country has been on the rise, and the demand for therapeutic drugs has also increased. . Although a large number of research results have been applied to the treatment of IBD, which can maintain long-term remission, promote tissue healing, and reduce the rate of hospitalization and surgery to a certain extent, there are still many adverse reactions and safety hazards, such as human immune Functional inhibition, bacterial resistance, etc. Traditional Chinese medicine can regulate intestinal flora disorder, maintain the stability and diversity of intestin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/06A61K36/539A61K47/18A61P1/00A61P29/00A61P31/04A61P39/06
CPCA61K47/18A61K36/539A61K9/06A61K9/0024A61P1/00A61P29/00A61P31/04A61P39/06Y02A50/30
Inventor 冯传良孙萌
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products