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pH-sensitive digestive tract injured mucosa protective glue and application thereof

A technology for mucosal protection and digestive tract, applied in the field of biomedicine, can solve the problems of restricted use and no good products on the market, and achieve the effect of promoting proliferation and migration, and promoting mucosal healing.

Active Publication Date: 2020-10-13
HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the materials currently on the market are difficult to fix on the wound surface, which limits its clinical use.
Therefore, there is still no better product on the market

Method used

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  • pH-sensitive digestive tract injured mucosa protective glue and application thereof
  • pH-sensitive digestive tract injured mucosa protective glue and application thereof
  • pH-sensitive digestive tract injured mucosa protective glue and application thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022]

[0023] The above ingredients Carbomer was dissolved in 45ml pure water, acid-soluble chitosan, hydroxypropyl methylcellulose, sodium alginate and β-glucan were dissolved in 45ml acetic acid solution, then the two liquids were mixed, and three Adjust the pH to 5.5 with ethanolamine, then adjust the volume to 100ml, pack in 5ml bottles, and sterilize by high-temperature steam.

[0024] The solidified solution is prepared into a 1.1% aqueous solution with calcium chloride, adjusted to pH=8.0, packaged in 5ml bottles, and sterilized by high-temperature steam.

example 2

[0026]

[0027] The above ingredients Carbomer was dissolved in 45ml of physiological water, acid-soluble collagen, sodium alginate and β-glucan were dissolved in 45ml of acetic acid solution, then the two liquids were mixed, the pH was adjusted to 5.0 with triethanolamine, and then the volume was adjusted to 100ml , 5ml per bottle, high temperature steam sterilization.

[0028] The solidified solution is prepared into a 1.1% aqueous solution with calcium chloride, adjusted to pH=8.0, packaged in 5ml bottles, and sterilized by high-temperature steam.

example 3

[0030]

[0031] The above ingredients Carbomer was dissolved in 45ml of physiological water, acid-soluble chitosan, collagen, hydroxypropyl methylcellulose, sodium alginate and β-glucan were dissolved in 45ml of acetic acid solution, and then the two liquids were mixed, Use sodium hydroxide solution to adjust the pH to 5.5, then adjust the volume to 100ml, pack in 5ml bottles, and sterilize by high-temperature steam. The solidification solution is prepared into a 2% aqueous solution with calcium gluconate, adjusted to pH=8.0, packaged in 5ml bottles, and sterilized by high-temperature steam.

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Abstract

The invention relates to a preparation method and a product of pH-sensitive digestive tract injured mucosa protective glue suitable to be sprayed on the surface of digestive tract injured mucosa by anendoscope, and belongs to the field of biological medicine preparations. The digestive tract injured mucosa protective glue comprises colloidal liquid and stationary liquid, wherein the colloidal liquid comprises a pH-sensitive biological material, a pH regulator, a biological adhesive, an ion-sensitive biological material and a dissolving solution, and the stationary liquid is a water-soluble calcium ion solution. Under the condition of low pH, the product is liquid and forms a colloidal film under the condition of physiological pH, so that the stimulation effect of intestinal digestive juice on digestive tract injured mucosa is avoided, and the healing of a wound surface is promoted. An animal test shows that the protective glue can obviously promote the repair of the injured mucosa, sothat the protective glue has the healing promoting and protecting effects for esophagus mucosa, intestinal mucosa and skin injury.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a pH-sensitive digestive tract mucosal protective glue suitable for spraying endoscopes on the damaged mucosal surface of the digestive tract and an application thereof. Background technique [0002] Gastrointestinal mucosal injury occurs from the esophagus, duodenum to rectum, some injuries are caused by diseases, and some are caused by surgery. Minimally invasive surgery for early cancer and benign tumor resection of esophagus and colon can replace some traditional surgery, which can not only achieve the goal of eradicating early cancer, but also has the advantages of less trauma and less impact on the quality of life of patients. It has gradually replaced some traditional surgery . However, at present, the mucosal wounds caused after such operations are only treated with hemostasis, and there are no good wound protection measures. Under the action of digestive juice, exp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/716A61K31/715A61K9/06A61K47/36A61K47/38A61K47/42A61K47/32A61P1/04
CPCA61K31/716A61K31/715A61K9/06A61K47/36A61K47/38A61K47/42A61K47/32A61P1/04A61K2300/00
Inventor 戴建英
Owner HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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