A kind of pharmaceutical composition for preventing and treating myocardial ischemia and its preparation method and application
A technology for myocardial ischemia and acute myocardial ischemia, applied in drug combinations, pharmaceutical formulations, cardiovascular diseases, etc.
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Embodiment 1
[0021] Example 1 : Preparation of Secnidazole Solid Lipid Microparticles
[0022] Secnidazole-loaded solid lipid particles (SLM) were prepared by anti-solvent precipitation.
[0023] Preparation method: Add 25 mg of secnidazole and 100 mg of glyceryl palmitate PrecirolATO5 to 100 ml of isopropanol, and heat to 45°C until the solid is completely dissolved. At the same time, 100 mL of deionized water was heated to the same temperature. The organic solution was then injected into water using a syringe equipped with a 251 / 2G gauge needle under constant stirring at 500 rpm. Stirring was continued for 15 minutes at room temperature. The pH of the resulting slurry was adjusted to 1.5 by adding 0.1M hydrochloric acid to flocculate the precipitated particles. Put the aggregated particles in the Centrific TM Centrifuge at maximum speed for 20 minutes. The supernatant was then removed, and the pellet was washed twice with deionized water. Using a freeze dryer overnight, the precip...
Embodiment 2
[0024] Example 2 : Preparation of Secnidazole Solid Lipid Microparticles
[0025] Secnidazole-loaded solid lipid particles (SLM) were prepared by anti-solvent precipitation.
[0026] Preparation method: Add 45 mg of secnidazole and 150 mg of glyceryl behenate into 100 ml of isopropanol, and heat to 70°C until the solid is completely dissolved. At the same time, 100 mL of deionized water was heated to the same temperature. The organic solution was then injected into water using a syringe equipped with a 251 / 2G gauge needle under constant stirring at 500 rpm. Stirring was continued for 25 minutes at room temperature. The pH of the resulting slurry was adjusted to 2.0 by adding 0.1M hydrochloric acid to flocculate the precipitated particles. Put the aggregated particles in the Centrific TM Centrifuge at maximum speed for 25 minutes. The supernatant was then removed, and the pellet was washed twice with deionized water. Using a freeze dryer overnight, the precipitated part...
Embodiment 3
[0027] Example 3 : Preparation of Secnidazole Solid Lipid Microparticles
[0028] Secnidazole-loaded solid lipid particles (SLM) were prepared by anti-solvent precipitation.
[0029] Preparation method: Add 45 mg of secnidazole and 150 mg of glyceryl caprylate to 100 ml of isopropanol, and heat to 55°C until the solid is completely dissolved. At the same time, 100 mL of deionized water was heated to the same temperature. The organic solution was then injected into water using a syringe equipped with a 251 / 2G gauge needle under constant stirring at 500 rpm. Stirring was continued for 15 minutes at room temperature. The pH of the resulting slurry was adjusted to 1.5 by adding 0.1M hydrochloric acid to flocculate the precipitated particles. Put the aggregated particles in the Centrific TM Centrifuge at maximum speed for 20 minutes. The supernatant was then removed, and the pellet was washed twice with deionized water. Using a freeze dryer overnight, the precipitated parti...
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