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Preparation method for degreased periplaneta americana linnaeus extract

A technology of Periplaneta americana and an extract is applied in the field of preparation of a defatted Periplaneta americana extract, and can solve the problems of heavy fishy odor, deep color of the extract, and no effect of preventing and treating peptic ulcer.

Active Publication Date: 2020-10-02
杭州海狮佳科技有限公司 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anti-ulcer active substance in the extract of Periplaneta americana is a polypeptide component. The oil not only has no effect on preventing and treating peptic ulcer, but can also aggravate the degree of ulcer. Moreover, the obtained extract has a deep color and a strong fishy smell, which makes some patients resist it during use. Therefore, it is of real value to find a preparation process of Periplaneta americana extract with high content of polypeptide active ingredients and no fishy smell.

Method used

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  • Preparation method for degreased periplaneta americana linnaeus extract
  • Preparation method for degreased periplaneta americana linnaeus extract

Examples

Experimental program
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Effect test

Embodiment 1

[0037] 1. Inactivation and crushing: fresh worms of Periplaneta americana are killed at 60°C, cleaned, dried at a temperature of 60°C ± 5°C, crushed, and passed through a 12-mesh sieve to obtain coarse powder of Periplaneta americana;

[0038]2. degreasing: the American cockroach coarse powder gained in step 1 is packed into a filter basket, dropped into a subcritical extraction kettle, the airtight extraction kettle is pressurized to 0.4MPa, and the organic extractant (n-butane) is pressurized to make For liquefaction at room temperature, add the pressurized liquid organic extractant to the subcritical extraction tank, adjust the ratio of solid to liquid to 1:6~12 (g / ml), and raise the temperature until the organic extractant in the subcritical extraction tank is in a subcritical state. The solvent is reclaimed under reduced pressure, the oil and the dregs are collected respectively, and the dregs are taken to obtain the defatted Periplaneta americana;

[0039] 3. Extraction:...

Embodiment 2

[0046] 1. Inactivation and crushing: fresh worms of Periplaneta americana are killed at 60°C, cleaned, dried at a temperature of 60°C ± 5°C, crushed, and passed through a 12-mesh sieve to obtain coarse powder of Periplaneta americana;

[0047] 2 degreasing: the American cockroach coarse powder gained in step 1 is put into the filter basket, put into the subcritical extraction kettle, the airtight extraction kettle is pressurized to 0.4MPa, and the organic extractant (n-butane) is pressurized to make it For liquefaction at normal temperature, add the pressurized liquid organic extractant to the subcritical extraction tank, adjust the ratio of solid to liquid to 1:6-12 (g / mL), raise the temperature until the organic extractant in the subcritical extraction tank is in a subcritical state, reduce Press to recover the solvent, collect grease and medicinal residues respectively, and get the defatted Periplaneta americana by taking the medicinal residues;

[0048] 3. Extraction: Add ...

Embodiment 3

[0055] 1. Inactivation and crushing: fresh worms of Periplaneta americana are killed at 60°C, cleaned, dried at a temperature of 60°C ± 5°C, crushed, and passed through a 12-mesh sieve to obtain coarse powder of Periplaneta americana;

[0056] 2. degreasing: the American cockroach coarse powder gained in step 1 is packed into a filter basket, dropped into a subcritical extraction kettle, the airtight extraction kettle is pressurized to 0.4MPa, and the organic extractant (n-butane) is pressurized to make For liquefaction at room temperature, add the pressurized liquid organic extractant to the subcritical extraction tank, adjust the ratio of solid to liquid to 1:6~12 (g / ml), and raise the temperature until the organic extractant in the subcritical extraction tank is in a subcritical state. The solvent is reclaimed under reduced pressure, the oil and the dregs are collected respectively, and the dregs are taken to obtain the defatted Periplaneta americana;

[0057] 3. Extraction...

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Abstract

The invention provides a preparation method for a degreased periplaneta americana linnaeus extract. The preparation method comprises the following steps: (1) killing and grinding; (2) degreasing; (3)extracting; (4) concentration under reduce pressure; (5) degreasing and filtering; (6) macroporous adsorption resin column chromatography; (7) concentration under reduce pressure. According to the degreased periplaneta americana linnaeus extract prepared by the preparation method, ineffective components such as grease, polysaccharide and macromolecular protein are effectively removed, polypeptidecomponents with good anti-ulcer activity in periplaneta americana Linnaeus are enriched, the content of the polypeptide component reaches 85% or more; and the obtained degreased periplaneta americanalinnaeus extract has light color and is odor-free.

Description

technical field [0001] The invention belongs to the field of extraction of traditional Chinese medicinal materials, in particular to a preparation method of defatted Periplaneta americana extract. Background technique [0002] Periplaneta Americana Linnaeus (Periplaneta Americana Linnaeus), commonly known as "cockroach", is the largest insect in the cockroach family. The adult body is 29-40 mm long, reddish brown, and the wings are longer than the end of the abdomen. The antennae are very long, and there is a large butterfly-shaped brown stripe in the middle of the pronotum, and the rear edge of the stripe has a complete yellow stripe. Periplaneta americana is native to South America and has a wide range of food habits, including sugar and starch. [0003] Periplaneta americana is a traditional Chinese medicinal material, which was first seen in "Compendium of Materia Medica Supplements". It is also known as Shijiang and slippery insects, and its adults are used as medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K38/01A61P1/04
CPCA61K35/64A61K38/012A61P1/04Y02A50/30
Inventor 胡万程曙光徐建军刘保国刘猛刚
Owner 杭州海狮佳科技有限公司
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