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Liver-protecting composition, and preparation method and application thereof

A composition and a liver-protecting technology are applied in the fields of medicine, food or health food to achieve the effects of significant liver damage protection, no effect on weight gain, and simple extraction process operation.

Active Publication Date: 2020-09-29
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no recognized leading brand in the domestic market for products with protective functions against chemical liver damage, so the development of liver protection products containing traditional Chinese medicine will have broad market prospects

Method used

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  • Liver-protecting composition, and preparation method and application thereof
  • Liver-protecting composition, and preparation method and application thereof
  • Liver-protecting composition, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 750g of kudzu root, 500g of rhodiola rosea, 500g of ganoderma lucidum, and 500g of ginseng, add 10 times the amount of water to decoct and extract twice, each time for 1.5 hours, filter, combine the two extracts, and concentrate under reduced pressure at 70±5°C , and concentrated to a relative density of 1.20 to 1.25, dried under reduced pressure at 70±5°C to obtain a dry extract, crushed and passed through a 100-mesh sieve to obtain a dry extract powder. Weigh an appropriate amount of dry paste powder, add appropriate amount of auxiliary materials, mix evenly, add appropriate amount of 95% ethanol, stir to make a suitable soft material, granulate with a 20-mesh screen, dry at 65±5°C, control the moisture content of the granules below 5.0%, and use a 20-mesh Sieve granules, after granulation, add appropriate amount of auxiliary materials and mix evenly, after mixing evenly, fill to make 1000 granules.

Embodiment 2

[0034] Take 15kg of kudzu root, 10kg of rhodiola rosea, 10kg of ganoderma lucidum, and 10kg of ginseng, add 10 times the amount of water to decoct and extract twice, each time for 1.5 hours, filter, combine the two extracts, and concentrate under reduced pressure at 70±5°C , and concentrated to a relative density of 1.20 to 1.25, dried under reduced pressure at 70±5°C to obtain a dry extract, which was pulverized into a fine powder passing through a 100-mesh sieve with a universal pulverizer to obtain a dry paste powder.

[0035] Mixing: Weigh an appropriate amount of dry paste powder and auxiliary materials into a wet mixing granulator, and mix evenly.

[0036] Making soft material: Add appropriate amount of 95% ethanol and stir to make suitable soft material.

[0037] Granulation: The prepared soft material is granulated with a 20-mesh sieve by a swinging granulator.

[0038] Drying: spread the wet granules on a baking tray, dry at 65±5°C, control the moisture content of th...

Embodiment 3

[0041] Example 3 Drug efficacy test of liver-protecting and liver-protecting effect of the composition of the present invention

[0042] Blank group: Distilled water was given, and the mice were gavaged according to 0.1mL / 10g·BW body weight.

[0043] Model group: Modeling was carried out by adopting the "auxiliary protective effect on chemical liver injury" (alcoholic liver injury model) in the "Technical Specifications for Health Food Inspection and Evaluation" (2003 edition) issued by the Ministry of Health. Distilled water was given, and the mice were gavaged according to 0.1 mL / 10 g·BW body weight.

[0044]Experimental group: the sample of Example 2. The recommended dosage for human body is 9g crude drug / 60kg·BW per day. Three dosage groups were set up in the experiment, namely: 1.5, 3, 4.5g crude drug / kg·BW three dosage groups were low, middle and high, respectively equivalent to 10 times, 20 times and 30 times of the recommended human intake. The samples were prepared ...

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PUM

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Abstract

The invention provides a liver-protecting composition which is characterized by comprising the following components in parts by weight: 1-6 parts of radix puerariae, 1-4 parts of roots of kirilow rhodiola, 1-4 parts of ganoderma lucidum and 1-4 parts of ginseng. the radix puerariae, roots of kirilow rhodiola, ganoderma lucidum and ginseng are reasonable in compatibility and have a synergistic effect; the four medicines are combined and interact to jointly achieve the effects of clearing damp-heat, dispelling the effects of alcohol toxin, dredging the liver and gallbladder and removing stagnation, and achieve a good relieving effect on chemical liver injury; and therefore, the effect of protecting the liver is achieved.

Description

technical field [0001] The invention relates to the field of medicine, food or health food, in particular to a composition for protecting the liver and its preparation method and application. Background technique [0002] Chemical liver injury is liver injury caused by chemical hepatotoxic substances. Alcohol, as one of the important sources of hepatotoxic substances, has become a problem that cannot be ignored in today's society. With the development of my country's economy and people's lives With the improvement of the level of liver disease, the incidence of chemical liver injury is increasing year by year, seriously affecting the health of Chinese people. [0003] At present, there is no recognized leading brand in the domestic market for products with protective functions against chemical liver damage, so the development of liver protection products containing traditional Chinese medicine will have broad market prospects. Contents of the invention [0004] In view of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61P1/16A23L33/105A23L31/00A23L5/10
CPCA61K36/488A61K36/41A61K36/074A61K36/258A61P1/16A23L33/105A23L31/00A23L5/10A61K2236/331A61K2236/39A61K2236/51A23V2002/00A61K2300/00A23V2200/32A23V2250/208A23V2250/21A23V2250/2124A23V2300/10A23V2300/14A23V2250/082
Inventor 肖伟张海弢李曼曼付娟杨晓筱范业文柏伟荣
Owner JIANGSU KANION PHARMA CO LTD
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