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Natural product Loureirin B analogue as well as preparation method and application thereof

A technology for natural products and analogs, applied in the field of natural product loxin B, can solve the problems of high cost, limited plant resources, complicated separation process of compounds, etc., and achieve the effects of low cost and simple and easy method.

Inactive Publication Date: 2020-09-25
SHANGHAI UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] Due to the limited plant resources of dracaena dracaena, and the uneven distribution of resources, and the process of isolating compounds from dracaena dracaena is complicated, the quality control is difficult, and the separated products also contain multiple components, the stability of the drug is not ideal, and the cost is relatively high. High, unable to meet a large number of needs, this has become a technical problem that needs to be solved urgently

Method used

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  • Natural product Loureirin B analogue as well as preparation method and application thereof
  • Natural product Loureirin B analogue as well as preparation method and application thereof
  • Natural product Loureirin B analogue as well as preparation method and application thereof

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Embodiment Construction

[0023] Below in conjunction with specific implementation example, above-mentioned scheme is described further, and preferred embodiment of the present invention is described in detail as follows:

[0024] In this example, if figure 1 Shown, a kind of preparation method of natural product Loureirin B analog LB-A, the steps are as follows:

[0025] a. Preparation of intermediate product SM:

[0026] Add 1-(2,4-bis(benzyloxy)phenyl)ethan-1-one) and 1.6g of 2,4-dimethoxybenzaldehyde in the one-necked bottle, and then add Add 50mL of methanol to dissolve, and add 1.5g of potassium hydroxide under constant stirring to obtain a mixed solution; then place the mixed solution in an oil bath, heat up to 60°C, and react overnight; perform TLC detection; the reaction is complete, Then cool to room temperature and filter to obtain a yellow solid compound, which is the intermediate product SM;

[0027] b. Preparation of target compound LB-A:

[0028] Adopt intermediate product SM, pallad...

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Abstract

The invention discloses a natural product Loureirin B analogue as well as a preparation method and application thereof. The structure of the compound is shown in the specification. The preparation method of the natural product Loureirin B analogue is characterized in that 2,4-dimethoxybenzaldehyde and 1-(2,4-di(benzyloxy)phenyl)ethyl-1-ketone are used as starting materials, and aldol condensationand catalytic hydrogenation reaction are performed to obtain the natural product Loureirin B analogue. The preparation method has the advantages that the quality control is easy to carry out, massivepreparation can be realized, and the cost is low. The compound has an excretion promoting effect on insulin cells, and can be used for preparing candidate medicines for treating hyperglycemia. The method is simple and easy to implement, low in cost and suitable for application and popularization.

Description

technical field [0001] The invention belongs to the technical field of natural product loureirin B (Loureirin B), in particular to a preparation method and application of natural product loureirin B analogs. Background technique [0002] Diabetes is a metabolic disease characterized by hyperglycemia. Elevated blood glucose due to defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes will be accompanied by chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. Diabetes is a lifelong disease that is difficult to cure, and it is one of the culprits that plague human health. [0003] The natural product Loureirin B is 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one (1-(4-hydroxyphenyl )-3-(2,4,6-trimethoxyphenyl)propan-1-one) compound. Studies have shown that Loureirin B can promote insulin secretion and lower blood sugar. [0004] Due to the limit...

Claims

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Application Information

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IPC IPC(8): C07C49/84C07C45/74C07C45/62A61P3/10
CPCC07C49/84C07C45/74C07C45/62A61P3/10
Inventor 丁岩汀孙晓东陈沁
Owner SHANGHAI UNIV
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