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Application of Prussian blue in preparation of medicines for treating acute pancreatitis

A technology of acute pancreatitis and Prussian blue, applied in the application field of Prussian blue, can solve the problems of limited clinical application, complicated preparation and treatment process, etc.

Active Publication Date: 2020-09-25
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation and treatment process is complex, and its clinical application is limited by the drug's lipid solubility and other pharmacokinetic / pharmacodynamic issues

Method used

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  • Application of Prussian blue in preparation of medicines for treating acute pancreatitis
  • Application of Prussian blue in preparation of medicines for treating acute pancreatitis
  • Application of Prussian blue in preparation of medicines for treating acute pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) Add 2400mg of potassium ferricyanide and 5g of polyvinylpyrrolidone (PVP) into 60mL of 2M hydrochloric acid, and stir magnetically until a clear solution is obtained;

[0049] (2) Transfer the above-mentioned clear solution to an electric cooker, and react for 72 hours at a temperature of 200° C. and a pressure of 10 MPa;

[0050] (3) Take out and cool to room temperature, centrifuge, wash with deionized water for several times, and freeze-dry to obtain Prussian blue nanoparticles with a size of 2-400nm.

Embodiment 2

[0052] (1) Add 300 mg of potassium ferricyanide and 3 g of polyvinylpyrrolidone (PVP) to 50 mL of 2M hydrochloric acid, and stir magnetically until a clear solution is obtained;

[0053] (2) Transfer the above-mentioned clear solution to an electric cooker, and react for 48 hours at a temperature of 100° C. and a pressure of 20 MPa;

[0054] (3) Take out and cool to room temperature, centrifuge, wash with deionized water for several times, and freeze-dry to obtain Prussian blue nanoparticles with a size of 2-400nm.

Embodiment 3

[0056] Step A) Add 3960 mg of potassium ferricyanide and 35 g of polyvinylpyrrolidone (PVP) into 100 mL of 2M hydrochloric acid, and stir magnetically until a clear mixed solution is obtained;

[0057] Step B) Transfer the mixed solution to an oven at 80°C, age for 20 hours, take it out, cool to room temperature, centrifuge, wash with deionized water several times, dissolve in 50mL of 1.5M hydrochloric acid and set aside;

[0058] Step C) Transfer 20mL of the above solution to a hydrothermal kettle, place in an electric furnace, age at 120°C for 4h, take it out and cool to room temperature, centrifuge, wash with deionized water several times, and freeze-dry to obtain a pore size in the range of 3-20nm The inner size is 30-200nm mesoporous Prussian blue nanoparticles.

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Abstract

The invention provides application of Prussian blue in preparation of medicines for treating acute pancreatitis and a preparation method of Prussian blue nano-particles. Currently, no specific medicine against acute pancreatitis exists, so that a specific medicine for preventing and treating acute pancreatitis has certain practical significance.

Description

technical field [0001] The application relates to the application of Prussian blue, in particular, to the application of Prussian blue in the preparation of medicines for treating acute pancreatitis. Background technique [0002] Acute pancreatitis (Acute Pancreatitis, AP) is one of the common acute abdomen. The global incidence of acute pancreatitis is currently increasing. Furthermore, severe disease develops in 20-30% of patients with acute pancreatitis, with a mortality rate of 40%. In AP, pancreatic enzymes are activated, leading to digestion, edema, hemorrhage, and even pancreatic tissue necrosis. According to pathological classification, it can be divided into edema and hemorrhagic necrosis. Acute edematous pancreatitis is mild and has a good prognosis; while acute hemorrhagic necrotizing pancreatitis is dangerous and has a high fatality rate. It not only manifests as local inflammation of the pancreas, but also often involves multiple organs throughout the body. ...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61P1/18B82Y5/00
CPCA61K33/26A61P1/18B82Y5/00
Inventor 蔡晓军郑元义高维谢雪胡兵李艺陈磊
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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