Anti-diabetic nephropathy (DN) glossy privet fruit extract as well as preparation method and application

Abstract

The invention discloses an anti-diabetic nephropathy (DN) glossy privet fruit extract prepared by a method comprising the following steps: adding yellow wine and/or water to glossy privet fruits, steaming the glossy privet fruits for 10-30 h in a waterproof manner, taking out the glossy privet fruits, carrying out drying at 50-80 DEG C for 3-8 h, crushing the dried glossy privet fruits into coarsepowder, adding ethanol accounting for 30-80wt% of the coarse powder, performing ultrasonic extraction for 2-3 times and 0.5-2 h each time, mixing filtrates, recovering the ethanol under reduced pressure until no ethanol smell remains to obtain an extract, adding water to the extract for dispersion, loading AB-8 type microporous resin, performing elution sequentially with 5BV water and a 5BV ethanol solution with a volume concentration of 50% at a flow speed of 2BV/h, collecting an ethanol eluate, recovering the ethanol, and performing freeze-drying to obtain the glossy privet fruit extract. After active components of the glossy privet fruits are converted, the utilization value of the glossy privet fruits is enhanced, and the glossy privet fruit extract has high activity, can be developedinto a drug or healthcare food for treating DN and can be used for preparing various dosage forms to facilitate clinical application. The effect of an extracted compound component is better than thatof salidroside, a complex traditional extraction process for extracting the salidroside is avoided, and the problem of limited treatment effects of the salidroside is solved.

Description

technical field [0001] The invention belongs to the field of extraction of active ingredients of traditional Chinese medicines, and in particular relates to a Ligustrum lucidum extract for anti-diabetic nephropathy, a preparation method and application. Background technique [0002] Diabetic nephropathy (DN) is a common microvascular complication of diabetes and one of the leading causes of death in diabetic patients. In recent years, the incidence of DN has been increasing, but there is still no effective drug for the treatment of DN. Traditional Chinese medicine contains a variety of active ingredients, which can produce comprehensive therapeutic effects through multiple channels and multiple targets, and have obvious advantages and characteristics in the prevention and treatment of chronic metabolic diseases. In-depth research on traditional Chinese medicines with definite efficacy in the treatment of DN will help to better develop new drugs for the treatment of DN. [...

AI Technical Summary

Problems solved by technology

[0006] Aiming at the waste of Ligustrum lucidum resources and the high price of Rhodiola rosea existing in the prior art, the present invention provides an anti-DN Ligustrum lucidum extract and its preparation method and application. Ligustrum lucidum is processed, and the effective The components are transformed, and the content of salidroside is significantly increased, and it works together with other transformed components to enhance its anti-DN effect

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