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Anti-aging composition cationic nano-liposome as well as preparation method and application thereof

A technology of nano-liposomes and cationic lipids, which is applied in the directions of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of poor stability of cytotoxic cationic liposomes, and achieve the promotion of reproduction and growth, Promote synthesis, good targeting effect

Active Publication Date: 2020-08-18
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, cationic lipids commonly used in the preparation of cationic liposomes are mainly DOTAP ((2,3-dioleoyl-propyl)-trimethylamine), DOTMA (N-[1-(2,3-dioleoyl)propyl) ]-N,N,N-trimethylammonium chloride), DODMA (1,2-dioleyl-3-dimethylamino-propane), DOAB (N,N-dimethyloctadecylene Propyl ammonium bromide) and DC-Chol (cholesterol), but these lipids have certain defects such as cytotoxicity or poor stability of the prepared cationic liposomes

Method used

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  • Anti-aging composition cationic nano-liposome as well as preparation method and application thereof
  • Anti-aging composition cationic nano-liposome as well as preparation method and application thereof
  • Anti-aging composition cationic nano-liposome as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] A preparation method of anti-aging composition cationic nano-liposome, characterized in that the following steps are adopted:

[0103] A: Weigh lipids, astaxanthin, flax lignans, bakuchiol, hydroxy pinacolone retinoate, Cosolvent, cationic polymer, glycerin, deionized water, standby; the lipid is composed of cationic lipid and neutral lipid according to the mass ratio of 7:13, and the cationic lipid is N-[1(2, 3-Oxydodecylcarbamoyl)propyl]-N,N,N-trimethyltryptophanammonium iodide, N-(N',N'-dimethyl)propylsuccinate A mixture of monocholesterol ester monoamide and ceramide in a mass ratio of 3:1:0.5, the neutral lipid is dimyristoylphosphatidylcholine; the cationic polymer is biological sugar gum-polymer Ethylene glycol graft copolymer;

[0104] B: The lipid, astaxanthin, flax lignan, bakuchiol, hydroxypinacolone retinoate, and co-solvent weighed in step A are stirred at a speed of 700rpm with an IKA disperser To uniform, to obtain a clear liquid, as the internal phase...

Embodiment 2

[0109] A lotion:

[0110]

[0111] Weigh Phase A, Phase B and Phase C according to the proportions in the above table, and disperse and mix the raw materials in Phase A evenly at the speed of IKA disperser at 500-1500rpm; then put the weighed Phase B raw materials into A Phase, mix the two phases evenly under the condition of IKA disperser speed of 800-1500rpm; finally put the raw materials in phase C in turn, and mix them evenly under the condition of IKA disperser speed of 800-1500rpm. Wherein, the anti-aging composition cationic nanoliposome addition amount prepared in Example 1 in the skin care water formula is 1.0%.

Embodiment 3

[0113] A skin cream:

[0114]

[0115] Weigh the raw materials of Phase A, Phase B and Phase C according to the above table. Disperse and mix the raw materials in phase A evenly at the speed of 500-1500rpm in the IKA disperser, then heat to 80°C; then heat the weighed phase B raw materials to 82°C to melt; then add the melted raw materials of phase B to For phase A, emulsify under the condition that the homogenization speed of IKA homogenizer is 5000 rpm, and the emulsification time is 5min'; Mix well under the condition of 800-1500rpm. Wherein, the anti-aging composition cationic nanoliposome addition amount prepared in Example 1 in the skin cream formula is 10.0%.

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Abstract

The invention relates to an anti-aging composition cationic nano-liposome as well as a preparation method and application thereof. The composition is characterized by being prepared from the followingcomponents in parts by mass: 7 to 20 parts of lipoid, 1 to 8 parts of astaxanthin, 5 to 10 parts of secoisolariciresinol, 1 to 3 parts of psoralen, 1 to 3 parts of hydroxyl pinacolone retinoic acid ester, 2 to 10 parts of cosolvent, 3 to 6 parts of cationic polymer, 15 to 30 parts of glycerol and 10 to 65 parts of deionized water, wherein the lipoid is composed of cationic lipoid and neutral lipoid; wherein the cationic polymer is a biosaccharide gum-polyethylene glycol (PEG) grafted copolymer. The liposome simultaneously loads astaxanthin, secoisolariciresinol diglucoside, psoralen phenol and hydroxyl pinacolone retinoic acid ester, has the advantages of good stability, small and uniform particle size, high load content and encapsulation efficiency, good skin feeling and good anti-agingeffect, and can be conveniently added into cosmetics for use.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to an anti-aging composition cationic nano liposome and its preparation method and application. Background technique [0002] The problem of aging has always been the focus of human attention. In recent years, the rapid development of science and technology has accelerated the pace of functional cosmetics. Since the end of the 20th century, the field of beauty technology dominated by anti-aging has become hot, and anti-aging cosmetics have become more and more popular. [0003] Astaxanthin, flax lignans, bakuchiol, and hydroxypinacolone retinoate are the most potent anti-aging actives discovered so far. [0004] Astaxanthin is the natural antioxidant with the strongest antioxidant capacity found so far. Each astaxanthin molecule has two ionone rings. The hydroxyl and ketone groups on the rings must pass through the cell membrane when protecting the cell membrane, which makes shri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/34A61K8/35A61K8/49A61K8/55A61K8/60A61K8/63A61K8/67A61K8/68A61K8/86A61Q19/00A61Q19/08
CPCA61K8/14A61K8/35A61K8/602A61K8/347A61K8/671A61K8/492A61K8/63A61K8/68A61K8/553A61K8/86A61Q19/08A61Q19/00A61K2800/10
Inventor 王虹霞刘宇航陈玉燕宋心宇毕永贤蒋丽刚
Owner PROYA COSMETICS
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