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Multifunctional liquid metal embolizing agent as well as preparation and application thereof

A technology of liquid metal and embolic agent, applied in application, X-ray contrast agent preparation, surgical adhesive, etc., can solve the problems of lack of developing ability, high price, single curative effect, etc., and achieves multiple curative effects, convenient preparation, convenient and multi-functional the effect of

Active Publication Date: 2020-08-11
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problems of high price, lack of imaging ability and single curative effect of traditional embolic agents in clinical practice, the present invention proposes a new type of multifunctional liquid metal embolic agent to realize embolization, CT imaging, MRI imaging, drug loading, thermal conversion, Features such as magnetism provide the possibility for the combination of targeted embolization therapy with chemotherapy, hyperthermia and radiotherapy

Method used

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  • Multifunctional liquid metal embolizing agent as well as preparation and application thereof
  • Multifunctional liquid metal embolizing agent as well as preparation and application thereof
  • Multifunctional liquid metal embolizing agent as well as preparation and application thereof

Examples

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Embodiment 1

[0043] This embodiment is a preparation method of a novel magnetic liquid metal calcium alginate gel microsphere embolic agent, which specifically includes the following steps:

[0044] (1) Take 2g of iron nanoparticles, disperse evenly at the bottom of the beaker, take 10g of liquid metal (Ga 75.5 In 24.5) into the beaker drop by drop, so that the surface of the liquid metal is fully coated with iron nanoparticles; then the concentrated hydrochloric acid with a concentration of 36-37wt% is added dropwise on the surface of the liquid metal coated with iron nanoparticles to prepare a magnetic liquid metal (hydrochloric acid React with the oxide layer on the surface of the liquid metal, change the surface tension, and make the iron nanoparticles infiltrate into the liquid metal);

[0045] (2) Put an appropriate amount of magnetic liquid metal into the absolute ethanol solution (5wt%) of Pluronic F 127, and use ultrasonic method (ultrasonic breaker, Emerson, ultrasonic power 70%...

Embodiment 2

[0050] The difference between this example and Example 1 is that the iron nanoparticles in the step (1) of Example 1 are replaced by copper nanoparticles.

[0051] In this example, calcium alginate gel microspheres wrapped with liquid metal micro-nanoparticles containing copper nanoparticles were prepared. Copper nanoparticles are used as functional nanoparticles to improve the electrical and thermal conductivity of liquid metal and increase the adhesion.

Embodiment 3

[0053] The only difference between this embodiment and embodiment 1 is that the Ga in step (1) of embodiment 1 75.5 In 24.5 Liquid metal is replaced by Ga 80 In 20 liquid metal.

[0054] In this example, calcium alginate gel microspheres wrapped with magnetic liquid metal micro-nanoparticles were prepared.

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Abstract

The invention provides a multifunctional liquid metal embolizing agent as well as a preparation and an application thereof. The multifunctional liquid metal embolizing agent is prepared from liquid metal, functional nanoparticles and a high polymer material, wherein the liquid metal is spherical and forms an inner core of the embolization agent; the functional nanoparticles are dispersed on the surface of the liquid metal; and the high polymer material coates outside the inner core and the functional nanoparticles. The multifunctional liquid metal embolization agent provided by the invention can realize the functions of embolization, CT imaging, MRI imaging, drug loading, thermal conversion, magnetism and the like, and is expected to realize the combination of targeted embolization treatment with chemotherapy, thermal therapy and radiotherapy; and the preparation method of the multifunctional liquid metal microsphere embolization agent provides possibility for more quickly and conveniently preparing the multifunctional microsphere embolization agent with multiple curative effects and diagnosis and treatment integration.

Description

technical field [0001] The invention belongs to the field of metal materials, and in particular relates to a functional liquid metal embolic agent, its preparation method and application. Background technique [0002] Embolization, also known as embolization therapy, is to controlly inject embolism materials into the supply vessels of diseased tissues or organs through arterial or intravenous catheters, so as to make them occluded and block the blood supply, so as to control bleeding, treat vascular diseases, Tumors and the purpose of eliminating the function of diseased organs. Embolization therapy mainly depends on various embolic agents, which can be divided into two categories: liquid embolic agents and solid embolic agents according to their physical properties. Liquid embolic agents include absolute ethanol, calcium alginate gel, liquid silica gel, n-butyl α-cyanoacrylate, lipiodol, etc. Solid embolic agents include mechanical embolic agents such as detachable balloo...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L24/00A61L24/08A61L24/10A61K49/04A61K49/12A61K41/00A61P35/00
CPCA61L24/02A61L24/001A61L24/0015A61L24/08A61L24/104A61K49/04A61K49/12A61K41/0052A61P35/00C08L5/08C08L5/04
Inventor 汪达伟饶伟
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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