Application of rhizoma corydalis pain-relieving dropping pills to treatment of knee osteoarthritis
A technology of Yuanhu Zhitong Dropping Pills and knee osteoarthritis, applied in the field of medicine, can solve the problems of severe gastrointestinal adverse reactions of diclofenac sodium, and achieve the advantages of promoting chondrocyte proliferation, good clinical treatment effect, and reducing gastrointestinal irritation. Effect
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Embodiment 1
[0018] Embodiment 1 Animal experiment
[0019] 1. Materials and methods
[0020] 1.1 Experimental animals and grouping
[0021] 40 SPF female rats, weighing 200±20g. After adaptive feeding for 1 week, they were randomly divided into blank group, model group, Yuanhu Zhitong dropping pill group, diclofenac sodium sustained-release capsule combined with Yuanhu Zhitong dropping pill group (combined medication group), 10 rats in each group.
[0022] 1.2 Reagents and instruments
[0023] Yuanhu Zhitong Dropping Pills (Gansu Longshen Rongfa Pharmaceutical Co., Ltd.), Diclofenac Sodium Sustained-release Capsules (China Pharmaceutical University Pharmaceutical Co., Ltd.), Monoiodoacetate (MIA, Sigma, USA), IL-1α, ELISA kit of TGF-β (Beijing Oubei Biotechnology Co., Ltd.), full-wavelength scanning microplate reader (Thermo Company of the United States), low-temperature high-speed centrifuge (Beckman Company of the United States).
[0024] 1.3 Modeling method and administration metho...
Embodiment 2
[0037] Embodiment 2 clinical trials
[0038] In this example, 60 patients with knee osteoarthritis were subjected to a clinical trial.
[0039] 1. Clinical trials
[0040] 1.1 General Information
[0041] The present invention includes 60 patients with knee osteoarthritis, and is randomly assigned to group A (n=30) and group B (n=30). There was no significant difference in staging, blood routine before treatment, and blood biochemical indexes (P>0.05), which were comparable.
[0042] 1.2 Diagnostic criteria
[0043] Case selection was performed according to the diagnostic criteria of the "Guidelines for the Diagnosis and Treatment of Osteoarthritis" issued by the Orthopedic Branch of the Chinese Medical Association in 2007:
[0044] (1) Recurrent knee joint pain in the past 1 month;
[0045] (2) X-ray film (standing or weight-bearing position) shows joint space narrowing, subchondral bone sclerosis and (or) cystic degeneration, and osteophyte formation at the joint margin...
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