Preparation process of alpha-amyrin fine particles

Abstract

The invention relates to the technical field of preparation processes of amyrin, in particular to a preparation process of alpha-amyrin fine particles. The preparation process of the alpha-amyrin fineparticles comprises following steps: yeast synthesis, component extraction, critical expansion and inspection packaging, and a reactor adopted in the critical expansion comprises a uniform mixing bin, a negative pressure cavity and a controller; a pretreatment pipe is arranged in the center of the bottom of the negative-pressure cavity; a nozzle is arranged at the top end of the pretreatment pipe. Since the degrees of micro-nuclei separated out of the supercritical solution in the instant decompression expansion process are different, the particle size of the prepared fine particles is not stable enough, and the absorption effect of the fine particles in use is reduced; therefore, the uniform mixing bin is rotatably mounted on the bracket and is matched with the filter membrane in the negative pressure cavity, so that the particle size of micronucleus crystals separated out after the supercritical solution is expanded under reduced pressure is in a stable range, the absorption effectof fine particles in use is ensured, and the preparation quality of the alpha-amyrin fine particles is improved.

Description

technical field [0001] The invention relates to the technical field of preparation technology of balsamic resin alcohol, in particular to a preparation technology of α-aromatic resin alcohol fine particles. Background technique [0002] Arsinol is a kind of triterpenoids, which widely exists in the plant kingdom in the form of free or ester. There are two isomers of balsinol in nature, α-amsinol and β-amsinol. The ursolic acid extracted from loquat leaves containing triterpenoid saponins has a wide range of pharmacological activities and has great application value. Body α-amyrin is very important. The content of ursolic acid and α-amyrin in plants is low, which is not conducive to extraction and cannot meet its medicinal needs. In recent years, synthetic biology methods have been used to transform The synthesis pathway of microorganisms, realizes the mass production of medicinal ingredients, and shows effects in the application of many medicinal ingredients; for the introd...

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Problems solved by technology

[0004] There have also been some technical solutions for preparing α-amyresin fine particles in the prior art, such as a Chinese patent with the application number 2009102291585 disclosing a preparation process of α-amyresin fine particles. Critical fluid anti-solvent equipment, which consists of the following steps: configuration of α-amyresin liquid, carbon dioxide feed, α-amyresin crystallization, and inspection; Micronized particles are beneficial to human body absorption, can improve the solubility and curative effect of α-amyresinol, reduce the cost of use and side effects; the α-amyresinol ultrafine particles prepared in this technical scheme have unique advantages in clinical practice; but the The α-amyresin alcohol in the technical proposal is prepared by decompression and expansion in a supercritical fluid, and the equilibrium concentration of the solute in the supercritical fluid cannot be effectively controlled, so that the prepared α-amyresinol fine particles are used Absorption is affected in

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