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Composition for treating acute lung injury, and application thereof

A technology of acute lung injury and composition, which is applied in the field of composition for treating acute lung injury, and can solve the problems of inability to prevent acute lung injury, treating the symptoms but not the root cause, and complex etiology of acute lung injury

Inactive Publication Date: 2020-08-07
LINK HEALTH GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The etiology of acute lung injury is complex, its pathological mechanism has not been fully elucidated, and the mortality rate is high
At present, the treatment of acute lung injury mainly adopts high-dose corticosteroid pulse therapy, but there is a lack of convincing experimental evidence. A large number of clinical studies have confirmed that glucocorticoids can neither prevent the occurrence of acute lung injury nor have an effect on early acute lung injury. Therapeutic effect
The current drug treatment for acute lung injury is not effective, and there is a problem of treating the symptoms but not the root cause, and cannot fundamentally treat acute lung injury

Method used

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  • Composition for treating acute lung injury, and application thereof
  • Composition for treating acute lung injury, and application thereof
  • Composition for treating acute lung injury, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The therapeutic effect of embodiment 1 LH011+dexamethasone composition on acute lung injury

[0023] (1) Modeling and administration

[0024] Sixty SPF male SD rats, weighing 220-250g, were anesthetized, and the necks of the rats were disinfected with iodine, and a longitudinal incision of about 1 cm was made at the middle and lower third of the neck to expose the lower edge of the thyroid and turn it up Carefully separate and expose the anterior muscle group of the trachea, sharply separate the muscle group longitudinally to expose the trachea, place the animal obliquely with the head high and the bottom of the feet, insert a 1mL syringe (26G) into the trachea at about two tracheal rings under the cricoid cartilage ring, and push 2mg / kg lipopolysaccharide (LPS) solution, the administration volume is 0.8mL / kg, observe that there are no air bubbles in the nose, and immediately rotate the rat upright for 20 seconds after pushing it in, so as to ensure that the liquid med...

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Abstract

The invention discloses a composition for treating acute lung injury, and application thereof. The composition is prepared from (a) dexamethasone and (b) WX-UK1 or WX-671. The research finds that thecomposition formed by dexamethasone and WX-UK1 or WX-671 is safe in component, can effectively have a synergistic treatment effect on acute lung injury, reduces the death rate caused by acute lung injury, recovers normal lung functions, and has important medical prospects and economic values.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a composition for treating acute lung injury and its application. Background technique [0002] Acute lung injury can be divided into intrapulmonary factors (direct injury) and extrapulmonary factors (indirect injury) according to whether it is primary in the lungs. It is manifested by the release of inflammatory factors, resulting in pulmonary capillary damage and increased alveolar and capillary permeability. , resulting in diffuse pulmonary interstitial and alveolar edema, thereby affecting oxygenation and causing dyspnea in patients. The pathophysiological features are reduced lung volume, decreased lung compliance, and imbalance of ventilation / perfusion flow ratio, clinically manifested as progressive hypoxemia and respiratory distress, and lung imaging manifested as heterogeneous exudative lesions . [0003] The etiology of acute lung injury is complex, its pathological mechanism ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K31/495A61P11/00A61K9/00A61K47/26A61K47/10
CPCA61K9/0053A61K31/495A61K31/573A61K47/10A61K47/26A61P11/00A61K2300/00
Inventor 宋燕苏博雅汤宇晴王华
Owner LINK HEALTH GRP
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