Composition for treating acute lung injury, and application thereof
A technology of acute lung injury and composition, which is applied in the field of composition for treating acute lung injury, and can solve the problems of inability to prevent acute lung injury, treating the symptoms but not the root cause, and complex etiology of acute lung injury
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[0022] The therapeutic effect of embodiment 1 LH011+dexamethasone composition on acute lung injury
[0023] (1) Modeling and administration
[0024] Sixty SPF male SD rats, weighing 220-250g, were anesthetized, and the necks of the rats were disinfected with iodine, and a longitudinal incision of about 1 cm was made at the middle and lower third of the neck to expose the lower edge of the thyroid and turn it up Carefully separate and expose the anterior muscle group of the trachea, sharply separate the muscle group longitudinally to expose the trachea, place the animal obliquely with the head high and the bottom of the feet, insert a 1mL syringe (26G) into the trachea at about two tracheal rings under the cricoid cartilage ring, and push 2mg / kg lipopolysaccharide (LPS) solution, the administration volume is 0.8mL / kg, observe that there are no air bubbles in the nose, and immediately rotate the rat upright for 20 seconds after pushing it in, so as to ensure that the liquid med...
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