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Breathable antibacterial electrode sheet and preparation method thereof

An electrode sheet and conductive film technology, which is applied in the field of biomedical engineering, can solve the problems of heavy medical insurance burden, increased use cost of electrode sheets, and high economic cost of patients, so as to reduce the economic burden of patients, improve monitoring accuracy, and increase surgical safety. sexual effect

Active Publication Date: 2021-08-13
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tension glue electrodes have the following problems: ①The biological safety is not good, and the incidence of rash and dermatitis related to tension glue is high; due to the large covering area of ​​the electrodes, postoperative rash and dermatitis are widely criticized by patients; The conductive film has poor air permeability and perspiration performance. After long-term use during the operation (more than 1 hour of operation), the patient's sweat infiltration, skin elasticity and other factors lead to the misalignment of the electrode sheet, which in turn causes electrical signal instability, which greatly threatens the safety of the operation. ;③ Tension rubber electrodes are disposable consumables, and the cost of each set of electrodes exceeds 10,000 yuan. The patient pays a lot, the social and medical insurance burden is heavy, and the medical economy is poor.
Existing composite conductive hydrogels are difficult to meet various requirements such as conductivity, viscoelasticity, mechanical strength, and air permeability at the same time, and it is difficult to ensure high viscosity when the hydrogel swells under sweat; Smoothly separated from the electrode sheet, causing pollution to the electrode sheet, cannot be reused, and increases the use cost of the electrode sheet

Method used

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  • Breathable antibacterial electrode sheet and preparation method thereof
  • Breathable antibacterial electrode sheet and preparation method thereof
  • Breathable antibacterial electrode sheet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation method of the gas-permeable antibacterial electrode sheet of the embodiment of the present invention is specifically carried out according to the following steps:

[0046] S1, 1 part of eugenol and 5 parts of triisopropylsilane are reacted with 0.002 parts of boron trifluoride ether as a catalyst, and triisopropylsilane is used to protect the phenolic hydroxyl group in eugenol to avoid oxidation of the phenolic hydroxyl group;

[0047] According to the mass ratio of eugenol: egg yolk lecithin: β-sitoziol: sodium caseinate is 1: 5: 2.3: 2.3, weigh egg yolk lecithin, β-sitozil and sodium caseinate, and weigh the The reaction product of egg yolk lecithin, β-sitozol, sodium caseinate and eugenol was completely dissolved in 6ml of absolute ethanol at 40°C, and the mixture was quickly injected into the acetic acid buffer solution at a volume ratio of 1:1. The pH value of the acetic acid buffer solution is 6, and the stirring is continued for 40 minutes, and th...

Embodiment 2

[0060] The preparation method of the gas-permeable antibacterial electrode sheet of the embodiment of the present invention is specifically carried out according to the following steps:

[0061] S1, 1.1 parts of eugenol and 4.5 parts of triisopropylsilane were reacted with 0.001 part of boron trifluoride ether as a catalyst, and triisopropylsilane was used to protect the phenolic hydroxyl group in eugenol to avoid oxidation of the phenolic hydroxyl group;

[0062] According to the mass ratio of eugenol: egg yolk lecithin: β-sitoziol: sodium caseinate is 1.1: 3: 2.3: 2.5, weigh egg yolk lecithin, β-sitoziol and sodium caseinate, and weigh the The reaction product of egg yolk lecithin, β-sitoziol, sodium caseinate and eugenol was completely dissolved in 6ml of absolute ethanol at 50°C, and the mixture was quickly injected into the acetic acid buffer solution at a volume ratio of 1:1. The pH value of the acetic acid buffer solution is 7, and the stirring is continued for 35 minut...

Embodiment 3

[0073] The preparation method of the gas-permeable antibacterial electrode sheet of the embodiment of the present invention is specifically carried out according to the following steps:

[0074] S1, 1.2 parts of eugenol and 4 parts of triisopropylsilane are reacted with 0.0004 parts of boron trifluoride ether as a catalyst, and triisopropylsilane is used to protect the phenolic hydroxyl group in eugenol to avoid oxidation of the phenolic hydroxyl group;

[0075] According to the mass ratio of eugenol: egg yolk lecithin: β-sitoziol: sodium caseinate is 1.2: 4: 2.3: 2.7, weigh egg yolk lecithin, β-sitoziol and sodium caseinate, and weigh the The reaction product of egg yolk lecithin, β-sitozol, sodium caseinate and eugenol was completely dissolved in 4ml of absolute ethanol at 60°C, and the mixture was quickly injected into the acetic acid buffer solution at a volume ratio of 1:1. The pH value of the acetic acid buffer solution is 7, and the stirring is continued for 30 minutes,...

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Abstract

The invention discloses a gas-permeable antibacterial electrode sheet and a preparation method thereof, comprising a reusable electrode sheet and a conductive film detachable from the electrode sheet. The conductive film consists of a hydrogel layer, a silver layer and a hydrocolloid layer from bottom to top Composition, the electrode sheet and the hydrocolloid layer are closely pasted; the raw materials of the hydrogel layer include: eugenol, boron trifluoride ether, triisopropylsilane, liposomes, multi-walled carbon nanotubes, polydiallyl di Methylammonium chloride, nanocellulose, polyacrylamide, ammonium persulfate, methacrylic anhydride, polyhexamethylene monoguanidine hydrochloride, octylphenol polyoxyethylene ether, Tween‑80, anhydrous tris Fluoroacetic acid or boron trifluoride. The electrode sheet uses a composite conductive hydrogel as a conductive film, which has good conductivity and good biological safety. Under the action of sweat, it still has self-adhesiveness, is breathable, sweat-absorbent, and has antibacterial properties; it can be slightly deformed according to the elasticity of human skin. , without affecting the stability of the electrical signal; the electrode sheet is easy to remove and can be reused.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and relates to a breathable antibacterial electrode sheet and a preparation method thereof. Background technique [0002] Biomedical engineering is the comprehensive application of the principles and methods of life science and engineering science. From the perspective of engineering, it understands the structure, function and other life phenomena of the human body at multiple levels in molecules, cells, tissues, organs and even the entire human body system. The general term for artificial materials, products, devices and system technologies for disease treatment, human function assistance and health care; artificial organs and medical treatment equipment all belong to biomedical engineering. ECG electrodes are important medical treatment equipment for the treatment and cure of arrhythmia. The clinical requirements of the electrodes include ease of use and stable contact with the h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/28A61B5/265A61B5/259A61B5/266C08J3/075C08F265/10C08F2/48C08L33/26C08L1/02C08K9/04C08K3/04C23C18/44
CPCA61B5/259C08F2/48C08F265/10C08J3/075C08J2333/26C08J2401/02C08K9/08C08K2201/011C23C18/44C08K3/041C08F220/08
Inventor 高渊梁潇
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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