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A kind of Jinlian heat-clearing spray and preparation method thereof

The technology of a spray and golden lotus is applied in the field of golden lotus heat-clearing spray and its preparation, and can solve the problems of incapability of carrying, increasing medical cost, unfavorable atomization treatment and the like

Active Publication Date: 2021-11-30
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned nebulization therapy still has the following deficiencies: 1, the dosage of Jinlian Qingre Effervescent Tablet is large; drug absorption
3. The nebulization treatment takes a long time, and the single inhalation time is 5min-40min. The single treatment time is long, which is not conducive to patient compliance
4. Controlled by the atomization equipment, it needs to be maintained, cleaned and disinfected, etc., which increases additional medical costs and cannot be carried

Method used

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  • A kind of Jinlian heat-clearing spray and preparation method thereof
  • A kind of Jinlian heat-clearing spray and preparation method thereof
  • A kind of Jinlian heat-clearing spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Preparation of Jinlian Qingre Compound Extract:

[0056] Take 1400g nasturtium, 1600g Daqingye, 1100g gypsum, 700g Anemarrhena, 800g Rehmannia glutinosa, 800g Scrophulariaceae, 1150g fried bitter almonds, add 8 times the amount of water and 0.3% of the quality of the medicinal material SPE -007, heated to 40°C in a water bath, kept warm for 8 minutes, decocted for 90 minutes after deactivating the enzyme; then added water with 5 times the mass of medicinal materials, decocted for 40 minutes, combined the two decoction liquids, and filtered; put the filtrate on the column, large Pore ​​resin separation, eluting with 60% ethanol, recovering the ethanol in the eluent, concentrating under reduced pressure to an extract with a relative density of 1.20 (50°C), and then drying under reduced pressure to obtain the compound extract of Jinlian Qingre.

[0057] Preparation of the spray:

[0058] Take 25g of Jinlian Qingre compound extract, 3g of chitosan, 0.02g of sorbic acid, an...

Embodiment 2

[0060] Preparation of Jinlian Qingre Compound Extract:

[0061] Take 1500g nasturtium, 1500g Daqingye, 1125g gypsum, 750g Anemarrhena, 750g Rehmannia glutinosa, 750g Scrophulariaceae, 1125g fried bitter almonds, add 7 times the amount of water and 0.32% of the quality of the medicinal material SPE -007, heated to 40°C in a water bath, kept warm for 10 minutes, decocted for 90 minutes after inactivating enzymes; then added water with 5 times the mass of medicinal materials, decocted for 40 minutes, combined two decoctions, filtered; put the filtrate on the column, and Pore ​​resin separation, eluting with 60% ethanol, recovering the ethanol in the eluent, concentrating under reduced pressure to an extract with a relative density of 1.22 (50°C), and then drying under reduced pressure to obtain the compound extract of Jinlian Qingre.

[0062] Preparation of the spray:

[0063] Take 20g of Jinlian Qingre compound extract, 5g of borneol, 0.03g of sorbic acid, and 0.06g of trehalos...

Embodiment 3

[0065] Preparation of Jinlian heat-clearing compound extract: 1600g nasturtium flower, 1600g Daqingye, 1200g gypsum, 800g Zhimu, 800g rehmannia glutinosa, 800g Scrophulariaceae, 1200g fried bitter almond, add 8 times the amount of medicinal material quality water and 0.4% medicinal material quality Plant essence extraction complex enzyme SPE-007, heated to 40°C in a water bath, kept warm for 10 minutes, decocted for 90 minutes after deactivating the enzyme; then added 5 times the amount of medicinal material, decocted for 40 minutes, combined the two decoctions, and filtered; Put the filtrate on the column, separate the macroporous resin, elute with 60% ethanol, recover the ethanol in the eluent, concentrate under reduced pressure to an extract with a relative density of 1.18 (50°C), and then dry under reduced pressure to obtain Jinlian Qingre compound extract thing.

[0066] Preparation of the spray:

[0067] Take 22g of Jinlian Qingre Compound Extract, 5g of soybean lecithi...

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Abstract

The invention belongs to the technical field of pharmacy, and in particular relates to a golden lotus heat-clearing spray and a preparation method thereof. The Jinlian heat-clearing spray is made of the following raw materials in parts by weight: 18-25g Jinlian heat-clearing compound extract, 3-6g absorption accelerator, 0.02-0.04g preservative, and 0.05-0.1g stabilizer. Compared with the prior art, the Jinlian heat-clearing agent of the present invention improves the poor direct absorption, low bioavailability, and large dosage of Jinlian Qingre oral preparations, and has good stability, high bioavailability, good patient compliance, and easy administration. It is convenient, safe, and adapts to a wider range of patient groups.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a golden lotus heat-clearing spray and a preparation method thereof. Background technique [0002] Heat syndrome due to exogenous pathogenic factors refers to the symptoms of feeling the evil of the six evils or the warm and epidemic poison, which leads to the imbalance of health and camp, the imbalance of yin and yang in viscera, pathological rise in body temperature, accompanied by aversion to cold, red face, irritability, rapid pulse, etc. It is a type of heat syndrome caused by exogenous pathogenesis as the main clinical manifestation. Exogenous heat syndrome has the characteristics of rapid onset and rapid change of condition, which requires timely diagnosis and targeted treatment according to the etiology in a short period of time. At present, antiviral drugs such as acyclovir, ribavirin, and amantadine are mainly used in clinical treatment for patients with e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K36/8964A61P29/00A61P11/04A61K33/06
CPCA61K9/0078A61K33/06A61K36/195A61K36/315A61K36/704A61K36/71A61K36/736A61K36/804A61K36/808A61K36/855A61K36/8964A61K47/26A61K2236/19A61K2236/331A61K2236/55A61P11/04A61P29/00A61K2300/00
Inventor 窦啟玲徐蓉尹萍
Owner GUIZHOU YIBAI PHARMA CO LTD
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