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Alhagi sparsifolia sugar polymer and preparation method and application thereof

A technology of polymer and thorn sugar, applied in the field of medicine, can solve the problems of lack of clear structural features and physical and chemical properties, and achieve the effects of reducing the difficulty of separation and purification, convenient operation and remarkable effect.

Active Publication Date: 2020-07-14
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the camel thorn coarse sugar polymer has been reported, its structural characteristics and physical and chemical properties have not been clarified, and there is no report on the structure of the camel thorn sugar polymer
In addition, there is no report on the research on the prevention and treatment of osteoporosis of camel thorn sugar polymer at home and abroad.

Method used

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  • Alhagi sparsifolia sugar polymer and preparation method and application thereof
  • Alhagi sparsifolia sugar polymer and preparation method and application thereof
  • Alhagi sparsifolia sugar polymer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The camel thorn sugar polymer was prepared according to the following steps:

[0053] 1) Material selection: Soak 30kg of the aboveground part of camel thorn in water for 12 hours;

[0054] 2) Water extraction: extract the aerial part of camel thorn soaked in step 1) with 10 times the volume of hot water (100°C) for 2 hours, and collect the extract;

[0055] 3) Fractional alcohol precipitation: Concentrate the extract obtained in step 2) at 60°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 40%, leave it at room temperature for 24 hours, and then centrifuge to obtain supernatant 1 and precipitate 1, Collect the precipitate 1, which is the crude sugar polymer AP1; concentrate the supernatant 1 at 60°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 60%, leave it at room temperature for 24 hours, and then centrifuge to obtain the supernatant 2 and precipit...

Embodiment 2

[0062] The camel thorn sugar polymer was prepared according to the following steps:

[0063] 1) Material selection: Soak 30kg of camel thorn in water for 6 hours;

[0064] 2) Water extraction: extract the aboveground part of camel thorn soaked in step 1) with 5 times the volume of hot water (60°C) for 3 hours, collect the extract and residue, and dry the residue;

[0065] 3) Fractional alcohol precipitation: Concentrate the extract obtained in step 2) at 40°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 30%, leave it at room temperature for 10 hours, and then centrifuge to obtain supernatant 1 and precipitate 1, Collect the precipitate 1, which is the crude sugar polymer AP1; concentrate the supernatant 1 at 40°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 60%, leave it at room temperature for 10 hours, and then centrifuge to obtain the supernatant 2 and p...

Embodiment 3

[0070] The camel thorn sugar polymer was prepared according to the following steps:

[0071] 1) Material selection: Soak 30kg of the aboveground part of camel thorn in water for 10 hours;

[0072] 2) Water extraction: extract the aboveground part of camel thorn soaked in step 1) with 15 times the volume of hot water (90°C) for 10 hours, collect the extract and residue, and dry the residue;

[0073] 3) Fractional alcohol precipitation: Concentrate the extract obtained in step 2) at 70°C under reduced pressure, add ethanol for alcohol precipitation so that the volume concentration of ethanol is 60%, leave it at room temperature for 28 hours, and then centrifuge to obtain supernatant 1 and precipitate 1, Collect the precipitate 1, which is the crude sugar polymer AP1; concentrate the supernatant 1 at 70°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 80%, leave it at room temperature for 28 hours, and then centrifuge to ...

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Abstract

The invention discloses Alhagi sparsifolia sugar polymers AP3-2 and AP3-3 and an extraction method and application thereof, and the method is characterized in that the Alhagi sparsifolia sugar polymers are prepared by taking the overground part of Alhagi sparsifolia as a raw material through water extraction and alcohol precipitation, Sevag method deproteinization, DEAE cellulose column chromatography, gel column chromatography and the like. The AP3-2 is a saccharide polymer composed of mannose, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, arabinose and xylose; and AP3-3 is a saccharide polymer composed of arabinose. Meanwhile, the AP3-2 has remarkable osteogenesis promoting activity in an anti-osteoporosis experiment. These studies can provide a basis for the future application in the preparation of drugs or health care products or functional foods for preventing and treating osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to a preparation method of camel thorn sugar polymer and refined sugar polymer, and the application of camel thorn sugar polymer in preventing and treating osteoporosis. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a systemic bone disease that reduces bone density and bone quality, damages bone microstructure, increases bone fragility, and is prone to fractures due to various reasons. Due to the increasingly serious phenomenon of population aging, the incidence of osteoporosis is increasing rapidly. Postmenopausal women's estrogen levels drop sharply, resulting in increased bone turnover rate and easy induction of osteoporosis. Osteoporosis has become a serious public health problem in today's society. The key to treating this common metabolic bone disease is maintaining a balance between bone resorption and bone formation. At present, hormone ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P19/10
CPCC08B37/0003C08B37/006A61P19/10
Inventor 严春艳叶振泉李天钰
Owner GUANGDONG PHARMA UNIV
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