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Method for establishing fingerprints of schisandra chinensis medicinal materials and erigeron breviscapus pulse-activating capsules

A technology for establishing methods and fingerprints, which is applied in the directions of material separation, material analysis, and measuring devices, and can solve the problems that the quality of Dengzhan Shengmai Capsules cannot be fully reflected, and the quality of lignan components cannot be fully reflected.

Pending Publication Date: 2020-07-07
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the 2015 edition of the "Chinese Pharmacopoeia" only controls the content of schisandrol A in schisandra lignans, which cannot fully reflect the quality of lignans in schisandra. Whether lignans can be better extracted and transferred to finished medicine cannot be judged
Therefore, it cannot fully reflect the quality of Dengzhan Shengmai Capsules

Method used

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  • Method for establishing fingerprints of schisandra chinensis medicinal materials and erigeron breviscapus pulse-activating capsules
  • Method for establishing fingerprints of schisandra chinensis medicinal materials and erigeron breviscapus pulse-activating capsules
  • Method for establishing fingerprints of schisandra chinensis medicinal materials and erigeron breviscapus pulse-activating capsules

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Experimental program
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Embodiment 1

[0080] 1. Instruments and reagents

[0081] Agilent 1200 high-performance liquid chromatograph, 1 / 100,000 electronic balance AY220 1 / 100,000 electronic analytical balance (Shimadzu), AS series ultrasonic cleaning machine (250W, 50Hz / 20Hz dual frequency) (Tianjin Autosine Sri Lanka Instruments Co., Ltd.). Agilent ZORBAX SB-C18 (5μm 4.6×250mm) chromatographic column.

[0082] Schisandra control medicinal material (National Institute for Food and Drug Control, batch number: 120922-201610) Schisandrin A (National Institute for Food and Drug Control, batch number: 110857, purity: 99.9%), acetonitrile is chromatographically pure, water is water for injection, and other reagents For analytical purity.

[0083] 2. Selection of chromatographic conditions

[0084] In the selection of chromatographic conditions for Schisandra chinensis and lignans in Dengzhan Shengmai Capsules, the mobile phase system was especially selected. The final chromatographic conditions are as follows: using...

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Abstract

The invention provides a method for establishing fingerprints of schisandra chinensis medicinal materials and erigeron breviscapus pulse-activating capsules. The method is divided into schisandra chinensis test sample treatment, erigeron breviscapus pulse-activating test sample treatment and reference substance solution preparation, and separate liquid phase detection; the liquid phase conditionsare as follows: acetonitrile is taken as a mobile phase A, water is taken as a mobile phase B, and gradient elution is carried out for 0-50 minutes: 35%-85% A, 65%-15% B; the column temperature is 30-40 DEG C, the detection wavelength is 240-260 nm, and the flow rate is 0.6-1.5 ml / min; according to the invention, the correlation between the schisandra chinensis medicinal material and the erigeronbreviscapus pulse-activating capsule is obtained through fingerprint comparison, and the quality control and tracing of the product are facilitated.

Description

technical field [0001] The invention belongs to the field of detection of traditional Chinese medicinal materials and preparations, in particular to a method for establishing fingerprints of lignans in Schisandra chinensis medicinal material and Dengzhan Shengmai Capsules Background technique [0002] Schisandra chinensis is the dry and mature fruit of Schisandra chinensis (Turcz.) Baill., a plant of Magnoliaceae, commonly known as "Northern Schisandra". There are astringent and astringent, nourishing qi and promoting body fluid, invigorating the kidney and calming the heart. Used for chronic cough and shortness of breath, nocturnal spermatorrhea, enuresis, frequent urination, chronic diarrhea, spontaneous sweating, thirsty wounds, internal heat and thirst, palpitations and insomnia. Schisandra lignans are lignans with 1,2,3,4-biphenyl-1,3-cyclooctadiene as the core, which is the main pharmacological active ingredient in Schisandra chinensis. There are more than 150 kinds ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/062
Inventor 林艳和唐琼涂栩秀苏海霞杜江
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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