A kind of chiral MOF material and its preparation method and application

A chiral and dimethyl technology, applied in separation methods, chemical instruments and methods, solid adsorbent liquid separation, etc., can solve single problems and achieve the effect of improving purity

Active Publication Date: 2021-09-28
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved in the present invention is to design and synthesize a single chiral MOF, and successfully apply it to chiral separation

Method used

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  • A kind of chiral MOF material and its preparation method and application
  • A kind of chiral MOF material and its preparation method and application
  • A kind of chiral MOF material and its preparation method and application

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Effect test

Embodiment 1

[0024] Such as figure 1 Shown, a kind of preparation method of chiral HPIAMOFs material specifically comprises the following steps:

[0025] (1) Dissolve 4.2 g of m-tribenzoic acid (compound 1) and 1 mL of concentrated sulfuric acid (catalyst) in anhydrous methanol (100 mL), and then reflux at 120° C. for 24 h. After the reaction was completed, most of the solvent was removed, and the resulting residue was slowly added to a saturated sodium bicarbonate solution, then stirred at room temperature for 1 hour, and filtered under reduced pressure to obtain 1,3,5-trimethyl-tribenzoate (compound 2) .

[0026] (2) 3.4g of compound 2 was placed in a 250ml round-bottomed flask, 150ml of methanol was added, 11.7 milliliters of 1mol / L NaOH solution was slowly added into the round-bottomed flask with a constant pressure dropping funnel, and the mixture was vigorously stirred for 24 hours, The solvent was then removed by rotary evaporation. 3.5 g of sodium bicarbonate and 65 ml of water ...

Embodiment 2

[0032] Prepare 1 ml ethanol suspension of HPIAMOFs (2 mg ml -1 ). First, the HPIAMOFs are filled into the capillary column by a vacuum pump at -0.02MPa to form a plunger about 5 meters long, and then the plunger is pushed at a rate of 0.8-1 meter per minute through the pump regulating valve. After coating, maintain the current condition pressure for 30 minutes. The coated capillary column was transferred to a gas chromatograph for conditioning by passing nitrogen gas through one end. Adjust the nitrogen flow rate to 0.02 MPa, and use the following temperature programming steps: 50 °C for 30 min, 1 °C min -1 to 240°C for 120 minutes.

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Abstract

The invention discloses a novel chiral MOF material and its preparation method and application. The material uses phenylalanine as a chiral source, and synthesizes a new ligand through an amide bond and a carboxylic acid bond on stribenzoic acid. The body and copper nitrate were hydrothermally reacted in a reactor for 3 days, washed three times with distilled water and ethanol respectively, and dried at 80°C to obtain the composite material. The material has specific chiral recognition ability, and can successfully separate some chiral molecules containing phenyl or π bonds. This porous chiral MOF material was successfully used for the separation of chiral compounds in the gas phase, proving that it is a promising new chiral stationary phase.

Description

technical field [0001] The invention belongs to the field of metal organic framework materials, and specifically relates to the synthesis of a novel chiral MOF and its successful application in chiral chromatographic separation. Background technique [0002] Currently, many drugs used in the pharmaceutical field are chiral. In most cases, only one enantiomer is pharmacologically active, while the other may be useless or even harmful. Therefore, the production and detection of chirally pure enantiopharmaceuticals is crucial. Metal-organic framework (MOF) is a new type of material, which is a three-dimensional periodic network structure self-assembled by metal ions and organic ligands. This novel material has the characteristics of large specific surface area, good thermal stability, and uniform nanopores, and it is widely used in many fields, such as molecular recognition, sensing, drug release, separation, gas storage, and catalysis. Chiral material MOF has the characteri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00B01D15/38
CPCB01D15/3833C08G83/008
Inventor 霍淑慧刘晨旭
Owner NORTHWEST NORMAL UNIVERSITY
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