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Nasal hepatitis b vaccine composition and method for producing same

A vaccine composition, hepatitis B technology, applied in the direction of biochemical equipment and methods, drug combinations, microorganisms, etc., can solve the problems of incomplete success, non-existence, etc., and achieve the effect of low side effects

Pending Publication Date: 2020-06-26
TOKO YAKUHIN IND CO LTD +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in its method of administration, it needs to be used in conjunction with subcutaneous vaccination to obtain an adequate immune response, i.e. it is a two-cycle vaccination, not a complete vaccine for nasal mucosal administration
[0007] As described above, as a next-generation hepatitis B vaccine, a nasal vaccine formulation that is widely used as an HBV vaccine for treatment and prevention is expected, but has not yet been completely successful

Method used

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  • Nasal hepatitis b vaccine composition and method for producing same
  • Nasal hepatitis b vaccine composition and method for producing same
  • Nasal hepatitis b vaccine composition and method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064]

[0065]

Embodiment 2

[0067]

[0068] Nasal hepatitis B vaccine compositions not containing gel matrix material were prepared as shown in the table below.

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PUM

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Abstract

The present invention relates to a hepatitis B vaccine composition for nasal mucosa spraying administration, characterized by comprising a hepatitis B antigen and a gel base containing a carboxyl vinyl polymer, and by being applicable to hepatitis B prevention and treatment.

Description

technical field [0001] The invention relates to a hepatitis B vaccine composition and its technology for nasal mucosal spray administration to prevent and treat hepatitis B. Background technique [0002] Hepatitis B is hepatitis caused by infection with the hepatitis B virus (HBV), which is transmitted through blood or body fluids. Persistent infection of liver cells by HBV can cause chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. [0003] Chronic hepatitis B (CHB) is currently treated mainly by using interferon agents (IFN) or nucleoside analog agents (NA) as first-line therapy. In IFN therapy, some effective examples have been reported, which increase immunity to effectively maintain the growth suppression of the virus, but in general, IFN therapy has a low HBV clearance rate and strong side effects, which is a big problem. On the other hand, NA therapy has a high HBV clearance rate of about 95%, but the therapeutic effect is temporary and cannot bring ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00A61K9/12A61K39/29A61K47/32A61P31/20A61P37/04
CPCA61K47/32A61P31/20A61P37/04A61K39/12A61K2039/543C12N2730/10134A61K9/0043A61K47/183A61K47/10A61K39/292A61K9/124A61K9/0078
Inventor 上下泰造宮崎隆小原道法真田崇弘日浅阳一吉田理小原恭子长谷川秀树
Owner TOKO YAKUHIN IND CO LTD
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