Bionic heterogeneous integrated bone-cartilage repair stent and preparation method thereof
A technology for cartilage repair and calcification of cartilage, applied in prosthetics, tissue regeneration, medical science, etc., can solve the problems of no multi-level structure, weak interface binding force, etc., and achieve good antibacterial properties, low cost, and strong plasticity
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Embodiment 1
[0053] 1. Preparation of Subchondral Bone Layer Precursor
[0054] (1) Dissolving 1.00g chitosan in an acetic acid solution with a volume fraction of 2%, magnetic stirring for 30min under 37°C water bath conditions, to obtain chitosan acid solution;
[0055] (2) Add 8 mL each of 2 mol / L calcium nitrate solution and 1.2 mol / L dipotassium hydrogen phosphate solution to the mixed solution obtained in step (1) in turn, stir well to make it evenly mixed, and obtain the subchondral bone layer complex Precursor solution; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;
[0056] (3) Inject the chitosan prepared in (2) and the uniform mixture of inorganic ions into the mould, and freeze in a refrigerator at -20°C to form solid A;
[0057] 2. Preparation of precursor composites of calcified cartilage layer and subchondral bone layer
[0058] (4) dissolving 0.75g chitosan in an acetic acid solution with a volume fraction of 2%, magnetic stirring for 30min under 37°C wat...
Embodiment 2
[0071] 1. Preparation of Subchondral Bone Layer Precursor
[0072] (1) Dissolving 1.00g chitosan in an acetic acid solution with a volume fraction of 2%, magnetic stirring for 30min under 37°C water bath conditions, to obtain chitosan acid solution;
[0073] (2) Add 8 mL each of 2 mol / L calcium nitrate solution and 1.2 mol / L dipotassium hydrogen phosphate solution to the mixed solution obtained in step (1) in turn, stir well to make it evenly mixed, and obtain the subchondral bone layer complex Precursor solution; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;
[0074] (3) Inject the chitosan prepared in (2) and the uniform mixture of inorganic ions into the mould, and freeze in a refrigerator at -20°C to form solid A;
[0075] 2. Preparation of precursor composites of calcified cartilage layer and subchondral bone layer
[0076] (4) dissolving 0.75g chitosan in an acetic acid solution with a volume fraction of 2%, magnetic stirring for 30min under 37°C wat...
Embodiment 3
[0089] 1. Preparation of Subchondral Bone Layer Precursor
[0090] (1) Dissolving 1.25g chitosan in an acetic acid solution with a volume fraction of 2%, magnetic stirring for 30min under 37°C water bath conditions, to obtain chitosan acid solution;
[0091] (2) Add 8 mL each of 2 mol / L calcium nitrate solution and 1.2 mol / L dipotassium hydrogen phosphate solution to the mixed solution obtained in step (1) in turn, stir well to make it evenly mixed, and obtain the subchondral bone layer complex Precursor solution; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;
[0092] (3) Inject the chitosan prepared in (2) and the uniform mixture of inorganic ions into the mould, and freeze in a refrigerator at -20°C to form solid A;
[0093] 2. Preparation of precursor composites of calcified cartilage layer and subchondral bone layer
[0094] (4) dissolving 1.00 g of chitosan in an acetic acid solution with a volume fraction of 2%, and magnetic stirring for 30 min under...
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