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Taurine synthesis method

A synthetic method, the technology of taurine, applied in the direction of sulfonic acid preparation, sulfonate preparation, chemical instruments and methods, etc., can solve problems such as high temperature and high pressure, achieve the effects of increasing yield, mild reaction conditions, and avoiding continuous accumulation

Active Publication Date: 2020-06-23
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of synthetic method of taurine, solve the problem of high temperature and high pressure in the by-product in the addition reaction existing in existing taurine synthetic technology and ammonolysis reaction

Method used

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  • Taurine synthesis method

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Effect test

Embodiment 1

[0037] Add 1000g of the prepared sodium bisulfite solution (24wt%) into the reactor, control the temperature at 45°C, then feed 106.7g of ethylene oxide, adjust the reaction pressure to 2bar, and stop the experiment after 45min. After cooling to room temperature, the addition reaction solution was selectively filtered using a PM280 nanofiltration membrane at a filtration temperature of 30°C and a pressure of 1 bar. After filtration, water was added for preparation. Add ruthenium hydroxide supported on zirconia with a loading capacity of 3% in a 1L high-pressure reactor in advance, the addition amount is 16.8g; take 700g of the prepared sodium isethionate solution (18.0wt%) and add it to the 1L high-pressure reactor During the process, feed liquid ammonia to make the concentration reach 19.0wt%, raise the temperature of the reaction system to 110°C, maintain the system pressure at 4MPa, and react for 30min. The yield of sodium taurate obtained by the ammonolysis reaction is 96.3...

Embodiment 2

[0039] Add 1000g of sodium bisulfite solution (10wt%) prepared into the reaction kettle, control the temperature at 25°C, then feed 50.8g of ethylene oxide, adjust the reaction pressure to 1bar, and stop the experiment after 10min. After cooling to room temperature, the addition reaction solution was selectively filtered using a PMS600 nanofiltration membrane at a filtration temperature of 10°C and a pressure of 0.1 bar. After filtration, water was added for preparation. Add 4% catalyst zirconia-supported ruthenium hydroxide in a 1L high-pressure reactor in advance, the addition amount is 17.6g; take 705g of the prepared sodium isethionate solution (10.0wt%) and add it to the 1L high-pressure reactor During the process, feed liquid ammonia to make the concentration reach 30.0wt%, raise the temperature of the reaction system to 80°C, maintain the system pressure at 1MPa, react for 10min, and the yield of sodium taurate obtained by the ammonolysis reaction is 70.7%. After the re...

Embodiment 3

[0041] Add 1000g of sodium bisulfite solution (30wt%) prepared into the reaction kettle, control the temperature at 95°C, then feed 126.9g of ethylene oxide, adjust the reaction pressure to 7bar, and stop the experiment after 70min. After cooling to room temperature, the addition reaction solution was selectively filtered using a PM280 nanofiltration membrane at a filtration temperature of 50°C and a pressure of 5 bar. After filtration, water was added for preparation. In advance in 1L high-pressure reactor, add the catalyst titanium oxide supported ruthenium hydroxide that load is 5%, add-on 2.84g (0.8wt%); Get the sodium isethionate solution (40wt%) after allocating 711g and add to In a 1L high-pressure reactor, feed liquid ammonia to make the concentration reach 25.0wt%, raise the temperature of the reaction system to 150°C, maintain the system pressure at 5.5MPa, and react for 60min. The yield of sodium taurate obtained by the ammonolysis reaction is 75.4%. After the react...

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Abstract

The invention provides a safe and efficient taurine synthesis method. The taurine synthesis method comprises the following steps: adding sodium hydrogen sulfite and ethylene oxide to prepare sodium isethionate; carrying out ammonolysis on sodium hydroxyethyl sulfonate and liquid ammonia at a high temperature to obtain sodium taurate; acidifying sodium taurate, and carrying out crystallization to obtain a taurine pure product. Before addition reactions, impurities are filtered by a nano-filtration membrane, and the side reaction influence is eliminated. The method has the advantages of mild ammonolysis reaction conditions and shortened reaction retention time, and the industrial production is safe and efficient.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a method for synthesizing taurine, in particular to process optimization for addition liquid removal of by-products and ammonolysis reaction. Background technique [0002] Taurine, also known as diethylsulfonic acid, is a sulfur-containing non-protein amino acid. Widely present in tissue cells and abundant in the brain. It has the functions of promoting the growth and development of the nervous system and cell differentiation, preventing cardiovascular diseases, affecting lipid absorption, improving immunity, and maintaining normal reproductive needs; therefore, it is widely used in medical treatment, health care, food, etc., and has a good market prospect. [0003] At present, the technology of artificially synthesizing taurine is relatively mature, and the main synthetic methods are ethanolamine method and ethylene oxide method. Among them, the ethylene oxide m...

Claims

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Application Information

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IPC IPC(8): C07C303/02C07C303/22C07C303/32C07C303/44C07C309/14B01J23/46
CPCC07C303/02C07C303/22C07C303/32C07C303/44B01J23/462C07C309/14
Inventor 蔺海政桂振友郭斌赵凯飞黄真真孔令晓丰茂英付广权陈来中张永振
Owner WANHUA CHEM GRP CO LTD
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