Methyl CpG binding protein 2-based (MECP2-based) method for injecting virus into specific brain area of animal without therapeutic aim to perform gene editing
A technology of gene editing and viruses, which is applied in the field of constructing non-human primate ASD disease models, can solve the problems of unsolvable chimerism of embryo transgenic technology, difficult research needs, high mortality rate of transgenic monkeys, etc., to avoid embryo transgenic technology Issues of chimerism, avoidance of genetic differences, effects of addressing research needs
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[0013] At present, the injection of animal models for this disease should focus on rodents, mainly mice. Rodents are far from human relatives, lack a correspondingly developed cerebral cortex, and have simple social behaviors. Their brain development process is similar to that of humans. Also very different. (Johnson, Wang et al.2015), non-human primates, especially macaques, have a genetic similarity with humans as high as 93.5%, and are very similar to humans in terms of physiological structure, developmental process, brain function and behavioral performance . More importantly, the macaque is a naturally social animal, which has obvious advantages over other animals for the study of diseases with typical social disorders such as ASD.
[0014] Therefore, the embodiment of the present invention proposes a method of directly injecting virus into a specific brain region of a non-human primate for gene editing, and the rhesus monkey is used as an example for illustration below....
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