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Protein microcapsules for targeted inhibition of small intestinal amylase and preparation method

A protein and amylase technology, applied in the field of nutrition and health, to achieve the effect of uniform shape, inhibition of activity, and small and uniform particle size

Pending Publication Date: 2020-06-19
苏州朗邦营养科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on the sustained release of protein-based α-amylase inhibitors

Method used

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  • Protein microcapsules for targeted inhibition of small intestinal amylase and preparation method
  • Protein microcapsules for targeted inhibition of small intestinal amylase and preparation method
  • Protein microcapsules for targeted inhibition of small intestinal amylase and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0044] A protein microcapsule capable of targeting and inhibiting intestinal amylase and a preparation method thereof. Specific steps are as follows:

[0045] (1) Take 100 parts each of wheat flour, rye flour, highland barley flour, sorghum flour and barley flour, respectively disperse them in 1000 parts of deionized water containing 2% NaCl, extract at room temperature for 2 hours, centrifuge (9600g, 10min) to get the supernatant , add ammonium sulfate powder until its saturation is 75%, let it stand for 2h, centrifuge (9600g, 10min) to get the precipitate, dialyze and desalt after reconstitution, and vacuum dry to prepare wheat extract, rye extract, highland barley extract, Sorghum extract and barley extract are compounded according to the content ratio of 5:10:1:5:1 to obtain the grain extract.

[0046] (2) Dissolve 5 parts of cereal extract and 10 parts of polysaccharide in 400 parts of deionized water. Add 1.3 parts of calcium carbonate powder to make it evenly disperse...

Embodiment 2

[0051] A protein microcapsule capable of targeting and inhibiting intestinal amylase and a preparation method thereof. Specific steps are as follows:

[0052] (1) Take 100 parts each of wheat flour, rye flour, highland barley flour, sorghum flour and barley flour, disperse them in 1000 parts of deionized water containing 5% NaCl, extract at room temperature for 2 hours, and centrifuge (9600g, 10min) to get the supernatant , add ammonium sulfate powder until its saturation is 80%, let it stand for 2h, centrifuge (9600g, 10min) to get the precipitate, reconstitute and then dialyze and desalt, vacuum dry and extract respectively wheat extract, rye extract, highland barley extract and sorghum extract Grain extract and barley extract are compounded according to the content ratio of 2:8:3:5:5 to obtain the grain extract.

[0053] (2) Dissolve 4 parts of cereal extract and 4 parts of polysaccharide in 800 parts of deionized water. Add 0.8 parts of calcium carbonate powder to make i...

Embodiment 3

[0058] A protein microcapsule capable of targeting and inhibiting intestinal amylase and a preparation method thereof. Specific steps are as follows:

[0059] (1) Take 100 parts each of wheat flour, rye flour, highland barley flour, sorghum flour and barley flour, disperse them in 1000 parts of deionized water containing 0.5% NaCl, extract at room temperature for 2 hours, and centrifuge (9600g, 10min) to get the supernatant , add ammonium sulfate powder until its saturation is 85%, let it stand for 2h, centrifuge (9600g, 10min) to get the precipitate, dialyze and desalt after reconstitution, and vacuum dry to obtain rye extract, highland barley extract, sorghum extract and The barley extract is compounded according to the content ratio of 10:2:3:8:1 to obtain the grain extract.

[0060] (2) Dissolve 4 parts of cereal extract and 5 parts of polysaccharide in 500 parts of deionized water. Add 0..6 parts of calcium carbonate powder to make it evenly dispersed.

[0061] (3) Slo...

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Abstract

The invention discloses protein microcapsules for targeted inhibition of small intestinal amylase and a preparation method, and belongs to the field of nutrition and health. The microcapsules are prepared from protein alpha-amylase inhibitor extracts in cereals or legume crops as a core material, and microencapsulation of the core material is achieved by combination with a specific water-in-oil emulsion-electroporation technology. Microcapsule powder products which have high embedding efficiency, uniform morphology and small particle size, and can release in the small intestine in a targetedmanner are prepared. The cereal extracts prepared by the method have good slow-release effect, and have obvious inhibitory effect on small intestinal alpha-amylase, thereby having the functions of lowering blood sugar and losing weight. The products can be applied to the fields of common food, health food, formula food for special medical use and the like, and provides a new solution for food of diabetic and obese people.

Description

technical field [0001] The invention relates to a protein microcapsule capable of targeting and inhibiting small intestinal amylase and a preparation method thereof, belonging to the field of nutrition and health. Background technique [0002] Diabetes mellitus is a group of chronic metabolic disorders of sugar, protein, fat, electrolyte and various hormones caused by the interaction of genetic and environmental factors that cause absolute or relative insufficiency of insulin secretion and (or) decreased sensitivity of target cells to insulin. disease, often accompanied by multiple complications. According to the 2017 "IDF Global Diabetes Overview (Eighth Edition)" statistics, there were 425 million diabetic patients in the world in 2017, of which 114 million were in my country; it is estimated that by 2040 there will be 150 million diabetic patients in China, and the It will also increase to 641 million. The number of diabetic patients in my country ranks first in the worl...

Claims

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Application Information

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IPC IPC(8): A23L33/185A23L29/256A23L29/231A23L29/10A23L29/00A23P10/30A23L5/30A23L5/00A61K9/50A61K36/48A61K36/70A61K36/899A61K36/8998A61P3/10B01J13/02
CPCA23L33/185A23L29/256A23L29/231A23L29/10A23L29/015A23L29/03A23P10/30A23L5/30A23L5/00A61K36/899A61K36/70A61K36/8998A61K36/48A61K9/5036A61P3/10B01J13/02A23V2002/00A23V2250/5482A23V2250/5488A23V2250/5026A23V2250/5072A23V2250/1578A23V2250/18A23V2200/222A23V2300/12A23V2300/10A23V2200/328A23V2200/332A61K2300/00
Inventor 赵伟樊启磊李舒宇费颖
Owner 苏州朗邦营养科技有限公司
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