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Preparation method of medical adhesive

An adhesive and organic solvent technology, applied in the field of preparation of solvent-free medical adhesives, can solve problems such as harmful to human health, and achieve the effects of reducing damage, low cytotoxicity, and improving adhesion effect

Active Publication Date: 2020-06-12
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most polymers are solid at room temperature and need to be dissolved in organic solvents to form solutions or emulsions before they can be used, and organic solvents are often harmful to human health.

Method used

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  • Preparation method of medical adhesive
  • Preparation method of medical adhesive
  • Preparation method of medical adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1, trimethylolpropane tris(3-mercaptopropionate) (39.86g, 10mmol) was dissolved in 240mL N'N-dimethylformamide, N 2 Bubble 30min to get rid of the air in the solution, then add 2-(acryloyloxy) ethyl methacrylate (18.58g, 10mmol), N 2 Under the protection of 40 ° C reaction for 24h. After the reaction, the reaction solution was concentrated by a rotary evaporator, and then precipitated in anhydrous ether to obtain a colorless transparent viscous liquid. The product was then redissolved in 40 mL of dichloromethane and precipitated by adding to 400 mL of diethyl ether. Repeat the above dissolution-precipitation operation 3 times, and vacuum dry to obtain a colorless viscous hyperbranched polymer, recorded as HBP1, with a molecular weight of 12kDa.

[0029] Step 2, the above hyperbranched polymer HBP1 (1mol in terms of thiol functional groups) and polyethylene glycol dimethacrylate (PEGDMA, molecular weight is 700Da, 0.2mol in terms of methacrylate functional groups,...

Embodiment 2

[0031] Same as Example 1, but change the addition amount of polyethylene glycol dimethacrylate (PEGDMA, 0.4mol in terms of methacrylate functional group) in step 2), and the rest of the operations are the same to obtain the adhesive, which is named as 1 -0.4.

Embodiment 3

[0033] Same as Example 1, but change the addition amount of polyethylene glycol dimethacrylate (PEGDMA, 0.6 mol in terms of methacrylate functional group) in step 2), and the rest of the operations are the same to obtain the adhesive, which is named as 1 -0.6.

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Abstract

The invention provides a preparation method of a medical adhesive, and belongs to the field of biomedical materials. The solvent-free UV-excited medical adhesive which is liquid at room temperature isprepared by mixing a thiol-terminated hyperbranched polymer and a small amount of polyethylene glycol containing unsaturated double bonds. Due to the hydrophobicity of the hyperbranched polymer, multiple thiol groups at the tail end and flowability without a solvent, the adhesive shows high adhesive strength. The adhesive provided by the invention can be quickly cured under low-dose ultraviolet light, so that the damage of high-dose ultraviolet light to surrounding healthy tissues is reduced. In addition, the adhesive has an elastic modulus close to that of human soft tissues, so that the comfort of a patient is improved; and meanwhile, the adhesive shows low swelling property and low cytotoxicity, and has a great application prospect as a medical adhesive.

Description

technical field [0001] The application belongs to the field of biomedical materials, and in particular relates to a preparation method of a solvent-free medical adhesive. Background technique [0002] Biomedical adhesive is a liquid medical adhesive material applied to the human body. It can be simply applied to the wound site, and through bonding, the tissue and tissue or non-tissue can be bonded together, so as to achieve wound closure, hemostasis and sealing. The medical adhesive is easy and quick to operate, does not cause damage to the damaged area, reduces pain, does not require secondary surgery to remove sutures, and can effectively prevent body fluids and air from leaking. Medical adhesives are widely used and have various functions. They can not only be used to close skin wounds, but also can be used to repair bones, nerves, muscles and other tissues. In addition, medical adhesives can also have superior cosmetic effects, leaving no scars after wound healing, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00A61L24/04
CPCA61L24/046C08G81/00
Inventor 李小杰张一帆魏玮刘晓亚
Owner JIANGNAN UNIV
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