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Blood-activating and pain-easing formula and blood-activating and pain-easing gel emplastrum

A plaster and formula technology, applied in the field of medical products, can solve the problems of rough administration method, unstable curative effect, easy to contaminate clothes, etc., achieve controllable drug absorption rate, avoid liver first-pass effect, and increase bioavailability Effect

Inactive Publication Date: 2020-06-12
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the reasonable ratio of the matrix and the ingredients of the traditional Chinese medicine, the gel plaster has a controllable dosage, good adhesion and continuous effect, can be pasted repeatedly, and does not pollute the clothes. Large compound preparations have problems such as no extraction, rough administration methods, easy contamination of clothes, inaccurate dosage, poor adhesion, poor drug permeability, and unstable curative effect, which facilitates clinical promotion and use

Method used

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  • Blood-activating and pain-easing formula and blood-activating and pain-easing gel emplastrum
  • Blood-activating and pain-easing formula and blood-activating and pain-easing gel emplastrum
  • Blood-activating and pain-easing formula and blood-activating and pain-easing gel emplastrum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 prescription for promoting blood circulation and relieving pain

[0053] The prescriptions for promoting blood circulation and analgesia prepared according to different proportions are shown in Table 1.

[0054] Table 1 Prescriptions with different proportions for promoting blood circulation and analgesia

[0055]

[0056]

Embodiment 2

[0057] Example 2 Performance Test of Promoting Blood and Analgesic Prescription

[0058] The seven different prescriptions for promoting blood circulation and analgesia prepared in Example 1 were tested.

[0059] 1. Experimental method

[0060] (1) Establishment of acute soft tissue contusion model in rats

[0061] Referring to the preparation of acute soft tissue contusion model in "Chinese Medicine Pharmacological Experimental Methodology", SD rats were selected, and after adaptive feeding for 3 days, they were anesthetized with 10% chloral hydrate at a dose of 0.35mL / 100g. After the rats were anesthetized, the rats' bilateral buttocks and thighs were removed with a shaver, and then the fine hairs were removed with 5% sodium sulfide, and cleaned with normal saline to reduce epidermal inflammation. Use a marker pen to mark the same position on the rat's leg at 1 cm from the popliteal fossa, lay the rat's leg flat, and fix it on a flat plate, place a hollow tube with an inne...

Embodiment 3

[0072] The single factor investigation of embodiment 3 gel cream matrix

[0073] 1. Investigation on the dosage of aluminum glycylate

[0074] (1) Preparation of Chinese medicine extract

[0075] The preparation of the Panax notoginseng extract is to weigh 200 g of the pulverized Panax notoginseng coarse powder, extract twice with 10 times the amount of 60% ethanol under reflux, each time for 30 minutes, combine the extracts, filter, and concentrate to 1 mL equivalent to 1 g of the original medicinal material. Concentration that is notoginseng extract.

[0076] The preparation of the extracts of Aconitum aconitum and Aconitum aconitum is to weigh 200g each of Aconitum aconitum and Aconitum aconitum, extract once with 8 times the amount of 70% ethanol under reflux, each time for 30min, combine the extracts, filter, and concentrate to 1mL The concentration equivalent to 1 g of the original medicinal material is to obtain the extract of Aconitum aconitum and the extract of Acon...

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Abstract

The invention discloses a blood-activating and pain-easing formula and a blood-activating and pain-easing gel emplastrum. According to the blood-activating and pain-relieving formula, a pseudo-ginsengextracting solution, a radix aconiti preparata extracting solution, a radix aconiti kusnezoffii preparata extracting solution and dragon's blood powder are scientifically matched, and the effects ofpromoting qi to activate blood, dispersing blood stasis to subdue swelling and stimulating menstrual flow to relieve pain are achieved; the invention further develops the blood-activating and pain-easing gel emplastrum. According to the gel emplastrum, through reasonable matching of a matrix and the traditional Chinese medicine components, the obtained gel emplastrum solves the problems that a traditional Chinese medicine blood circulation promoting and pain easing large compound preparation is not extracted, the administration mode is rough, clothes are prone to being polluted, the dosage isinaccurate, the adhesive force is poor, the medicine permeability is poor, and the curative effect is unstable, and clinical application and popularization are facilitated.

Description

technical field [0001] The invention relates to the technical field of medical products, in particular to a prescription for promoting blood circulation and analgesia and a gel patch for promoting blood circulation and analgesia. Background technique [0002] Acute soft tissue injury is one of the most common diseases in life. It is mainly caused by the damage of extraskeletal tissues and nerves caused by the human body being subjected to severe external force, such as: blunt sprain, abrasion or sharp violent impact, hard strong torsion and other injuries. Or a kind of acute injury of blood vessels, the injured part will often feel pain and swelling, and in severe cases, wounds will occur, which will bring the risk of infection and even affect tissue function. In traditional Chinese medicine, it is listed as a type of blood stasis syndrome, composed of blood The disease caused by obstructed circulation, poor operation and partial stasis and blockage of blood vessels plagues ...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K36/896A61K9/70A61K47/32A61K47/38A61K47/18A61P29/00
CPCA61K9/7046A61K9/7061A61K36/258A61K36/714A61K36/889A61K36/896A61P29/00A61K2300/00
Inventor 王利胜郑昊圳张艳余爱明
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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