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Application of euscaphis konishii hayata extract in preparation of diabetes drugs

The technology of C. serrata and diabetes medicine is applied in the field of application of C. serrata extract in the preparation of diabetes medicine, can solve the problems of less research on medicinal value and the like, and achieves improvement of pancreatic pathological changes and increased hepatic glucose levels. The original content, the effect of inhibiting the increase of blood sugar

Inactive Publication Date: 2020-06-12
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Corvus japonica is a traditional Chinese herbal medicine, which mainly treats stomach pain, bruises, rheumatism pain, dizziness, diarrhea, dysentery, etc., while Corvus dentata is mainly used as an ornamental plant, and there are few studies on its medicinal value at present. two plants of the same genus

Method used

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  • Application of euscaphis konishii hayata extract in preparation of diabetes drugs
  • Application of euscaphis konishii hayata extract in preparation of diabetes drugs
  • Application of euscaphis konishii hayata extract in preparation of diabetes drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take the dry pericarp of Arvenia crenidae, chop it into pieces, dry it at 50°C, and pulverize it to obtain powder. Boil and reflux extraction three times with 100 g of the fruit peel powder of Corvus dentata in the ratio of 1 L of water, extracting for 2 hours each time, combine the extracts, concentrate under reduced pressure to the extract, and then freeze-dry the extract to obtain the extract of C. Ravensia fruit peel extract.

Embodiment 2

[0019] Take the dried twigs of Toonia sylvatica, chop them into pieces, dry them at 50°C, and pulverize them to obtain powder. Boil and reflux the twig powder in the ratio of 100g to 1L of water to extract three times, extracting for 2 hours each time, combine the extracts, concentrate under reduced pressure to the extract, and then freeze-dry the extract to obtain the extract. Ravensia Twig Extract.

Embodiment 3

[0021] Take the dried leaves of S. crenariae, chop them up, dry them at 50° C., and pulverize them to obtain powder. Boil and reflux the leaf powder of Coryda sinensis at the ratio of 100g to 1L of water and extract three times, extracting for 2 hours each time, combine the extracts, concentrate under reduced pressure to the extract, and then freeze-dry the extract to obtain the extract. Ashwagandha Leaf Extract.

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Abstract

The invention relates to application of a euscaphis konishii hayata extract in preparation of diabetes drugs. According to the invention, the euscaphis konishii hayata extract is obtained by a water extraction method. A type 1 diabetic mouse model is constructed by adopting alloxan induction; a high-sugar high-fat feed is adopted for feeding, and a small dose of streptozotocin is injected for inducing and constructing a type 2 diabetic mouse model; after the euscaphis konishii hayata extract is administrated to the two diabetic mice, the blood glucose concentrations of the diabetic model micecan be effectively reduced, erum insulin content is adjusted, the liver glycogen content is increased, and the glycated serum protein content is reduced; in addition, the euscaphis konishii hayata extract can significantly improve the lipid metabolism disturbance of the type 2 diabetic mouse models, which indicates that the euscaphis konishii hayata extract has good prevention and treatment effects on type 1 and type 2 diabetes and can be applied to preparation of drugs for preventing and treating diabetes.

Description

technical field [0001] The invention belongs to the field of extraction and application of plant active substances, and in particular relates to the application of the extract of Jacuna dentata in the preparation of diabetes medicines. Background technique [0002] At present, diabetes has become one of the third major chronic diseases after cardiovascular diseases and malignant tumors. Hyperglycemia caused by insulin secretion defects or insulin receptor function impairments can easily lead to multiple organs and tissues in the human body (such as heart disease). Cerebral blood vessels, kidneys, nerves, retina, etc.) have serious lesions and dysfunction. Type 1 diabetes is mostly caused by autoimmune system deficiency, genetic factors, virus infection, etc. Insulin in the body is seriously insufficient, and it is usually treated by directly supplementing insulin in clinical practice; the most prominent feature of type 2 diabetes is insulin resistance, and its peripheral tar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P3/10
CPCA61K36/185A61K2236/15A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P3/10
Inventor 黄维邹双全邹小兴倪林陈路遥王玉启
Owner FUJIAN AGRI & FORESTRY UNIV
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