Preparation for inhibiting candida albicans

Abstract

The present application discloses a preparation for inhibiting candida albicans. The active ingredient of the preparation contains an SAalpha2-3Gal sugar chain structure (especially glycoproteins richin SAalpha2-3Gal sugar chain structure), and with the increase of a sialic acid glycoprotein concentration, the inhibitory effect on candida albicans growth is significantly enhanced; when the concentration of sialic acid protein is in the range of 100-200 [mu]g / mL, the preparation has a significant inhibitory effect on adhesion of CAL-27 cells by the candida albicans, and when the concentrationof the sialic acid glycoprotein reaches 200 [mu]g / mL, the candida albicans hardly grows, the preparation can play a sterilizing role; and the preparation can be sprayed directly on potential parts such as skin surfaces and oral cavities where the candida albicans grows, the active ingredient of the preparation is preferably a glycoprotein rich in SAalpha2-3Gal sugar chain structure separated and purified from milk.

Description

technical field [0001] The present application relates to a preparation for inhibiting Candida albicans. Background technique [0002] Candida albicans, also known as Candida albicans, is the most common opportunistic pathogenic fungus. It mainly exists in the respiratory tract, oral cavity and epidermis of the human body. Under normal conditions, it will not cause disease, but when the immune function of the human body is low, it will cause disease, and then pose a threat to the mucous membranes, tissues, skin and other organs of the human body, causing different diseases. The degree of Candida albicans disease can cause infection of organs such as the oral cavity in mild cases, and can cause systemic candida disease in the human body in severe cases. [0003] Candida albicans mainly grows as single cells, and Gram staining is positive, but the coloring is not very uniform. Candida albicans causes diseases due to its good ability to adapt to the environment and numerous v...

AI Technical Summary

Problems solved by technology

At present, there is no effective treatment for oral Candida albicans infection in T2DM patients, and most of them are treated with oral hypoglycemic drugs or antibiotics.

Images