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Metabolite extract of intestinal flora in American cockroach excrement as well as preparation method and application of extract

A technology of Periplaneta americana and intestinal flora, which can be used in drug combinations, medical raw materials derived from arthropods, cardiovascular system diseases, etc., and can solve problems such as increasing the incidence of arrhythmia

Active Publication Date: 2020-06-09
YUNNAN TENGCHONG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem that cardiotonic drugs in the prior art can increase the incidence of arrhythmia, the present invention provides a method for preparing an extract of metabolites of intestinal flora in feces of Periplaneta americana

Method used

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  • Metabolite extract of intestinal flora in American cockroach excrement as well as preparation method and application of extract
  • Metabolite extract of intestinal flora in American cockroach excrement as well as preparation method and application of extract
  • Metabolite extract of intestinal flora in American cockroach excrement as well as preparation method and application of extract

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Embodiment 1

[0035] The embodiment of the present invention provides an extract of intestinal flora metabolites in the feces of Periplaneta americana, the preparation method of which is as follows:

[0036] 1 kg of Periplaneta americana feces samples were ultrasonically extracted twice with 70% (v / v) ethanol aqueous solution, each time for 1 h, and the consumption of each ethanol aqueous solution was 8 L, filtered after extraction, and the solvent was recovered after the gained filtrate was combined to obtain the American cockroach. Periplaneta feces alcohol extract extract, add water to suspend into 750mL suspension, put on 500g D101 macroporous adsorption resin column after adsorption, elute with 2L water, then elute with 95% (v / v) ethanol aqueous solution , and collect the eluate of 95% (v / v) aqueous ethanol.

[0037] Concentrate the obtained eluate under reduced pressure, and then dry under reduced pressure to obtain the feces extract powder of Periplaneta americana.

Embodiment 2

[0039] The embodiment of the present invention provides an extract of intestinal flora metabolites in the feces of Periplaneta americana, the preparation method of which is as follows:

[0040] 1 kg of Periplaneta americana feces samples were ultrasonically extracted twice with 68% (v / v) ethanol aqueous solution, each time for 1.5 h, and the consumption of each ethanol aqueous solution was 9 L, filtered after extraction, and the solvent was recovered after the gained filtrate was combined to obtain Periplaneta americana feces alcohol extract extract, add water to suspend into 800mL suspension, put on 500g D101 macroporous adsorption resin column after adsorption, elute with 2L water, then wash with 93% (v / v) ethanol aqueous solution Remove, collect the eluate of 93% (v / v) ethanol aqueous solution, and concentrate under reduced pressure.

Embodiment 3

[0042] The embodiment of the present invention provides an extract of intestinal flora metabolites in the feces of Periplaneta americana, the preparation method of which is as follows:

[0043] 1 kg of Periplaneta americana feces samples were ultrasonically extracted twice with 72% (v / v) ethanol aqueous solution, each time for 1.5 h, and the consumption of each ethanol aqueous solution was 9 L, filtered after extraction, and the solvent was recovered after the gained filtrate was combined to obtain Periplaneta americana feces alcohol extract extract, add water to suspend into 700mL suspension, put on 500g D101 macroporous adsorption resin column after adsorption, elute with 2L water, then wash with 97% (v / v) ethanol aqueous solution Remove, collect the eluate of 97% (v / v) ethanol aqueous solution, and concentrate under reduced pressure.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to metabolite extract of intestinal flora in American cockroach excrement as well as a preparation method and an application of the extract. The extract adopts the American cockroach excrement as a raw material, is prepared by steps of ultrasonic extraction, filtration, macroporous resin separation and the like, has a positive inotropic action, can enhance normal myocardial contractility without obvious heart rate increase or heart damage, and can be used for preparing drugs for treating cardiac failure.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an extract of metabolites of intestinal flora in feces of Periplaneta americana and its preparation method and application. Background technique [0002] Heart failure is myocardial injury caused by myocardial infarction, cardiomyopathy, hemodynamic overload, inflammation and other reasons, often manifested as compensatory tachycardia. As an important vital sign, heart rate is one of the most direct and effective indicators for evaluating the functional state of the heart. Although increased heart rate can improve the hemodynamic status of patients with heart failure to a certain extent and alleviate the symptoms of heart failure, however, increased heart rate reduces the end-diastolic volume of the ventricles, resulting in a decrease in stroke volume and cardiac output. Decreased blood flow can cause the sympathetic nervous system to be excited ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P9/04
CPCA61K35/64A61P9/04
Inventor 王跃飞王子延李玉红王启隆吕伟奇牛璐刘香月柴欣杨静
Owner YUNNAN TENGCHONG PHARMA FACTORY
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