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Application of hydrogel nano carrier in anti-inflammatory anti-aging cream

A technology of hydrogel nano and nano-carriers, which is applied in the direction of medical preparations containing active ingredients, cosmetic preparations, skin care preparations, etc., which can solve the problem that products are difficult to pass through the skin, the effect is not satisfactory, and the functionalization Single and other problems, to prevent skin allergies, inhibit the formation of lipid peroxide, skin firm and smooth effect

Inactive Publication Date: 2020-06-09
广州古泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of cosmetic products on the market is not satisfactory, the products are difficult to penetrate the skin, poor water retention, single functional, easy to cause allergies and other shortcomings

Method used

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  • Application of hydrogel nano carrier in anti-inflammatory anti-aging cream
  • Application of hydrogel nano carrier in anti-inflammatory anti-aging cream
  • Application of hydrogel nano carrier in anti-inflammatory anti-aging cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 6

[0041] Test method: The long-acting nano hydrogel anti-inflammatory and anti-aging cream obtained in Examples 1-4 were used as test samples 1-4, and the cream obtained in Example 5 was used as control sample 1; 30-50 years old from the same area were randomly selected. 300 female volunteers with more acne, spots, wrinkles, and experience in using creams. After using test samples 1-4 and control samples 1, respectively, the scoring standard was designed and scored. The maximum value and the maximum value of each group of data were removed. The minimum value, take the average, and then count the scoring results in Table 3.

[0042] Scoring criteria: Refer to Table 2 for scoring criteria.

[0043] Scoring results: It can be seen from Table 3 that the long-acting nano hydrogel anti-inflammatory and anti-aging cream obtained by using the formula and preparation method of the present invention has good gloss, high apparent score, and good compatibility of the components of the formula. ...

Embodiment 7

[0049] Determination of solubility

[0050] Add 5 parts of 0.5g of rosin leaf extract and Gynostemma pentaphyllum to 50mL of deionized water to obtain a turbid mixture of rosin leaf extract and Gynostemma pentaphyllum, numbered 1 to 5, and add 1.5 to solutions 1 to 5 g, 2g, 2.5g, 3g, 3.5g hydroxyethylcellulose-sodium alginate hydrogel. Heat and stir at 60°C for 20 min. After cooling to room temperature, observe the dissolution of rosin leaf extract and Gynostemma pentaphyllum. The turbidity of No. 1 solution is relatively turbid, the turbidity of No. 2 solution is further reduced, and the turbidity of No. 3 to 5 becomes clear. It is proved that hydroxyethyl cellulose-sodium alginate hydrogel can significantly enhance the solubility of rosin leaf extract and Gynostemma in water.

Embodiment 8

[0052] Cytotoxicity test

[0053] Inoculate Hacat epidermal cells in a cell culture flask and place at 37°C, 5% CO 2 For culture in an environment, the medium is 1640 medium containing 10% fetal bovine serum and 0.5% double antibody. Inoculate the cultured cells in a 96-well plate with a cell density of 8000 cells / mL, and continue at 37°C, 5% CO 2 Cultivate 48h in the environment. Remove the medium in the 96-well plate, wash 3 times with pre-cooled PBS, add 1640 complete medium containing different gradients of hydroxyethyl cellulose-sodium alginate hydrogel, continue at 37 ℃, 5% CO 2 Cultivate for 24h in the environment. Remove the medium in the 96-well plate, add 200μL of MTT solution diluted to 5mg / ml with 1640 complete medium to each well, wrap it with tin foil and continue to incubate for 4h, remove the solution, add 100μL of DMSO, and fully dissolve the attachment in the 96-well plate Of formazan. Transfer the 96-well plate to a microplate reader, set the scanning wavelen...

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Abstract

The invention discloses an application of a hydrogel nano carrier in anti-inflammatory anti-aging cream. The anti-inflammatory anti-aging cream comprises an anti-inflammatory anti-aging composition, hydroxyethyl cellulose-sodium alginate hydrogel and the like, wherein the anti-inflammatory anti-aging composition comprises a rosin leaf extract, gynostemma pentaphyllum, ascorbyl glucoside, vitamin E, sorbitan monooleate, glycerol, allantoin and the like. According to the invention, the hydrogel nano carrier in anti-inflammatory anti-aging cream is prepared by wrapping anti-inflammatory components and anti-aging components by using the hydroxyethyl cellulose-sodium alginate hydrogel, and the hydroxyethyl cellulose-sodium alginate hydrogel is a nanometer carrier, and can be quickly absorbed byskins to pass through the cell membranes, so that the anti-inflammatory components and the anti-aging components are loaded into the skin cells, go deep into the skin to remove excess free radicals,and promote degradation of skin cutin and proliferation and metabolism of cells in the epidermal basa layer to enable the skin to be tender and elastic.

Description

Technical field [0001] The invention specifically relates to the application of a hydrogel nano carrier in an anti-inflammatory and anti-aging cream, belonging to the technical field of cosmetics. Background technique [0002] Cosmetics refer to chemical industrial products or fine chemical products that are spread on any part of the human body by applying, spraying or other similar methods to clean, maintain, beautify, modify and change the appearance, or to correct human odor and maintain good condition. . With the development of the economy and the continuous improvement of the quality of life, the awareness of young people in China to protect the skin has been increasing year by year, and the amount of consumer products for cosmetics has increased year by year, showing a rapid upward trend. However, the effects of cosmetic products on the market are not satisfactory. The products are difficult to penetrate the skin, have poor water retention, single function, and easily caus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/9767A61K8/73A61K8/67A61K8/92A61Q19/00A61Q19/08
CPCA61K8/678A61K8/731A61K8/733A61K8/922A61K8/927A61K8/9767A61K8/9789A61K2800/78A61Q19/00A61Q19/08
Inventor 祝发顺
Owner 广州古泉生物科技有限公司
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