Feed additive, application thereof and feed with strong antibacterial activity

A feed additive and feed technology, applied in application, animal feed, additional food elements, etc., can solve the problems of affecting the humoral immune function, destroying the balance of intestinal microbial flora of livestock and poultry, etc., and achieve strong antibacterial activity and strong antibacterial active effect

Inactive Publication Date: 2020-05-19
SHENZHOUSPACEBIOTECHGRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the feed industry, the application of antibiotic additives has promoted the development of animal husbandry, but the long-term use of antibiotics will not only cause drug resistance in livestock and poultry animals, but also antibiotic drug residues in the body will destroy the intestinal microorganisms of livestock and poultry Bacteria balance, affecting humoral immune function

Method used

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  • Feed additive, application thereof and feed with strong antibacterial activity
  • Feed additive, application thereof and feed with strong antibacterial activity

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preparation example Construction

[0017] For the preparation method of the feed additive in the present invention, conventional mixing methods are used to mix the above-mentioned components.

[0018] The present invention also provides the application of the feed additive described in the above technical solution in the preparation of feed for inhibiting Pseudomonas aeruginosa and / or Candida albicans.

[0019] The present invention also provides a feed with strong antibacterial activity. In the feed with strong antibacterial activity, the mass percentage content of the feed additive in the above technical solution is 0.5-15%.

[0020] In the present invention, the antibacterial is against Pseudomonas aeruginosa and / or Candida albicans.

Embodiment 1

[0023] Staphylococcus aureus ATCC6538P, Escherichia coli ATCC8099, Pseudomonas aeruginosa ATCC15442 and Candida albicans ATCC10231, these standard strains were purchased from the Culture Collection Center of the Institute of Microbiology, Chinese Academy of Sciences.

[0024] The antibacterial activity of feed additives was determined by the Oxford cup method, and the indicator bacteria (Staphylococcus aureus ATCC6538P, Escherichia coli ATCC8099, Pseudomonas aeruginosa ATCC15442 and Candida albicans ATCC10231) were activated and the bacterial concentration was adjusted to 10 6 cfu mL -1 , respectively mixed with feed additives, using the agar double-layer culture method, first prepare the bottom LB medium in a disposable petri dish, put a sterile Oxford cup on it, and then prepare the upper layer of LB agar medium, take out the Oxford cup, and put it in the hole Add 200 μL of the solution to be tested, seal it and place it at 32°C for constant temperature incubation, and obser...

Embodiment 2

[0029] In conventional feeding broilers, on the basis of feeding the basic ration, adding the feed additive of the present invention (added in liquid form) with a mass percentage content of 0.5 to 15%, the experimental results show that the addition of the feed additive can obviously improve the quality of broiler chickens. Body weight, reduce the incidence of diarrhea in broilers. Increased by 2.19~7.20% than blank control (replacing feed additive of the present invention with water), 0.76~4.83% higher than antibiotic group (flavomycin 5mg / kg); Feed conversion rate has improved 0.91~8.32% than blank control group, Compared with the antibiotic group, it increased by 0.04-5.64%.

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Abstract

The invention relates to a feed additive, an application thereof and a feed with strong antibacterial activity, and belongs to the technical field of feeds. The feed additive disclosed by the invention is prepared from the following components: acetophenone, valine, L-phenylalanine, choline, L-leucine, guanine, valeric acid, adenine, dioctyl phthalate, DL-beta-leucine, 6-methoxyquinoline, stearicacid, erucyl amide and 4-oxoproline. The feed additive disclosed by the invention does not contain antibiotics, can efficiently inhibit bacteria, and is a safe green feed additive for livestock and poultry.

Description

technical field [0001] The invention relates to the technical field of feed, in particular to a feed additive and its application and a feed with strong antibacterial activity. Background technique [0002] In the feed industry, the application of antibiotic additives has promoted the development of animal husbandry, but the long-term use of antibiotics will not only cause drug resistance in livestock and poultry animals, but also antibiotic drug residues in the body will destroy the intestinal microorganisms of livestock and poultry The balance of flora affects the humoral immune function. Due to the serious impact of antibiotics in the feed industry, finding alternatives to antibiotics is a hot topic in the current scientific research community. Contents of the invention [0003] The object of the present invention is to provide feed additive and feed with strong antibacterial activity. The feed additive of the invention does not contain antibiotics and can inhibit bac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/111A23K20/142A23K20/105A23K20/137A23K20/132
CPCA23K20/105A23K20/111A23K20/132A23K20/137A23K20/142
Inventor 马珺张文德王艳发印红徐侃彦袁俊霞党磊张秦陈宏博
Owner SHENZHOUSPACEBIOTECHGRP
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