Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of antiallergic sulfated polysaccharide and its preparation method and application

A sulfuric acid polysaccharide and anti-allergic technology, which can be used in allergic diseases, polysaccharide/gum-containing food ingredients, applications, etc., can solve the problem of low anti-allergic activity, and achieve the effects of reduced production costs, high safety, and low energy consumption

Active Publication Date: 2021-07-20
JIMEI UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of antiallergic sulfated polysaccharide in order to overcome the low problem of existing sulfated polysaccharide antiallergic activity, and it adopts common sulfated polysaccharide as raw material to carry out modification processing, and common sulfated polysaccharide originates from marine brown algae (such as kelp, Hijiki, Sargassum, Undaria pinnatifida, Sargassum, Stagweed, etc.), marine red algae (such as red hair algae, Eucheuma, Gracilaria, seaweed, Gemweed, Porphyra, Seaweed, Partridge, etc.) and Micrococcus have high anti-allergic activity after removing divalent metal ions (activation of sulfate groups), reducing molecular weight, and increasing retention of sulfate groups

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of antiallergic sulfated polysaccharide and its preparation method and application
  • A kind of antiallergic sulfated polysaccharide and its preparation method and application
  • A kind of antiallergic sulfated polysaccharide and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of anti-allergic fucoidan, refer to figure 1 ,Proceed as follows:

[0042] S1. Fucoidan solid-state infrared pre-degradation: Fucoidan derived from kelp (sulfate group is 35.4% by mass; calcium, magnesium, and manganese element contents are 12000mg / kg, 6540mg / kg, and 10500mg / kg respectively) Add deionized water to the dry powder, the amount of water added is 20% by mass, and then the wet fucoidan powder is prepared into a cake crust with a thickness of 0.1cm and spread on a clean stainless steel tray, and then put the tray into an infrared drying box, Keep the distance between the polysaccharide cake and the infrared lamp at 10 cm; use 3000w to heat for 1 hour to obtain dry pre-degraded fucoidan powder.

[0043] S2. Preparation of compound chelating agent: mix citric acid, polyaspartic acid, tartaric acid, sodium ethylenediamine tetraacetate (EDTA) and sodium pyrophosphate in a mass ratio of 3:3:2:1:1 to prepare a compound Chelating agent.

[0044] S3. Sy...

Embodiment 2

[0048] The preparation of antiallergic galactan sulfate, the steps are as follows:

[0049] S1, galactan sulfate solid-state infrared pre-degradation: the galactan sulfate (sulfate group is 11.2 mass %; calcium, magnesium, manganese element content is respectively 9870mg / kg, 4820mg / kg, 8960mg) / kg) dry powder was added deionized water, the amount of water added was 20% by mass, and then the galactan sulfate wet powder mass was prepared into a cake with a thickness of 0.1cm and spread on a clean stainless steel tray, and then put the tray into the infrared In the drying oven, keep the distance between the polysaccharide cake and the infrared lamp at 10 cm; use 3000w to heat for 1 hour to obtain the dry powder of pre-degraded galactan sulfate.

[0050] S2. Preparation of compound chelating agent: mix citric acid, polyaspartic acid, tartaric acid, sodium ethylenediamine tetraacetate (EDTA) and sodium pyrophosphate in a mass ratio of 3:3:2:1:1 to prepare a compound Chelating agen...

Embodiment 3

[0055] The preparation of antiallergic sulfated polysaccharides comprises the following steps:

[0056] S1: Carry out solid-state infrared pre-degradation of sulfated polysaccharides, add deionized water to sulfated polysaccharide dry powder (sulfated polysaccharide dry powder is obtained by extracting sulfated polysaccharides from Micrococcus and drying), to obtain sulfated polysaccharide wet powder, sulfated polysaccharide wet powder The sulfuric acid polysaccharide content in medium is 25% by mass, the wet powder is made into a dough, flattened into a cake skin with a thickness of 0.12cm, spread on a clean stainless steel tray, and then put the tray into an infrared drying box to make the cake skin and The distance of the infrared lamp is kept at 10cm; the infrared drying oven is selected at 2800w, and heated for 1h to obtain the pre-degraded sulfated polysaccharide dry powder;

[0057] S2: preparing a compound chelating agent, mixing citric acid, polyaspartic acid, tartari...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention relates to an anti-allergic sulfated polysaccharide and its preparation method and application. The anti-allergic sulfated polysaccharide uses sulfated polysaccharide as a raw material to remove divalent metal ions, and has the characteristics of low molecular weight and high sulfuric acid group content The molecular weight of the anti-allergic sulfated polysaccharide is 600Da-1000Da, and the retention of sulfate groups relative to the raw material sulfated polysaccharide is ≥95% by mass. The antiallergic sulfated polysaccharide prepared by the invention has simple production process and high production efficiency, and the obtained sulfated polysaccharide has strong antiallergic activity, and is very suitable for developing antiallergic drugs or functional foods.

Description

technical field [0001] The invention relates to the field of biological preparations, in particular to an antiallergic sulfated polysaccharide and its preparation method and application. Background technique [0002] With the increasing number of people with food allergies, food allergic diseases have become an important public health problem. Studies have shown that about 8% of children in the United States have food allergies (Gupta et al., 2011); the proportion of food allergies in European populations is as high as 6% (Nwaru et al., 2014); food allergies in 1-year-old children in Australia The incidence rate reaches 11% (Peters et al., 2017). In my country, the prevalence of food allergy increased from 3.5% in 1999 to 7.7% in 2009 (Hu et al., 2010). However, the drugs currently on the market for food allergy are mainly antihistamines, such as chlorpheniramine, loratadine, promethazine, etc. These drugs often treat the symptoms but not the root cause, and are highly res...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/737A61P37/08A23L33/125
CPCA23V2002/00A61K31/737A23L33/125A61P37/08C08B37/0063A23V2250/51A23V2200/304
Inventor 刘翼翔黄玲李东慧王彦波傅琳玲
Owner JIMEI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com