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Application of astragalin in preparation of drug for preventing or treating depression

A technology of ascarin and depression, applied in the field of medicine, can solve side effects and other problems, achieve strong antidepressant effect, solve the effect of treating depression and shorten immobility time

Inactive Publication Date: 2020-05-12
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs can play a certain antidepressant effect, they will produce a series of side effects along with their drug effects; and a survey shows that about one-third of antidepressant patients are forced to stop taking the drug because they cannot tolerate the side effects of the drug

Method used

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  • Application of astragalin in preparation of drug for preventing or treating depression
  • Application of astragalin in preparation of drug for preventing or treating depression
  • Application of astragalin in preparation of drug for preventing or treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 of the present invention discloses a kind of preparation method of antidepressant medicine, specifically comprises the following steps:

[0029] (1) Weigh 10g ascarin, 2g microcrystalline cellulose, 5g sodium carboxymethylcellulose, 1.5g crospovidone and 20g pregelatinized starch, set aside;

[0030] (2) Pass the 80-mesh sieve after the raw material is pulverized, fully mix, and add the ethanol that concentration is 60% twice, adopt wet granulation;

[0031] (3) The prepared granules are dried, and the dried granules are sized and blended, and then compressed into tablets to obtain milkvetch glycoside tablets.

Embodiment 2

[0032] Embodiment 2 antidepressant experiment

[0033] In this embodiment, the chronic stress stimulates the depression mouse modeling method as follows:

[0034] Before the depression modeling, the experimental mice were given 2% sugar water for 3 days to adapt. After 3 days, the mice in the normal group were reared separately from the mice in the other groups. Food and water should be fasted during the sugar water preference experiment, and they were free to eat at other times. The model animals were subjected to chronic mild stimulation for 3 weeks, including swimming in cold water (15°C, 6min); tail clamping (1min); water deprivation (24h); fasting (24h); °); wet rearing (100ml water was added to the bottom of the cage with sawdust); overnight lighting stimulation. That is, the mice received one stimulus every day, each stimulus was guaranteed to be carried out randomly but not continuously, and the number of overnight lighting stimulations was at least twice a week.

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Abstract

The invention discloses an application of astragalin in the preparation of a drug for preventing or treating depression. The experimental results indicate that astragalin can significantly shorten theTST and FST immobility time of CUMS mice and does not affect the autonomous activity of the mice, and indicate that astragalin has relatively strong antidepressant effects and no central excitatory or inhibitory effects. Moreover, astragalin can activate the SIRT1 / NLRP3 inflammatory body signaling pathway, and the results prove that astragalin plays an antidepressant role by regulating the SIRT1 / NLRP3 inflammatory body pathway, and can be used to prepare a drug for treating depression. Moreover, astragalin comes from cuscuta chinensis, belongs to non-toxic and harmless natural ingredients, and is safe to take. Moreover, astragalin can be conveniently prepared into a dosage form convenient to take with a pharmaceutically acceptable carrier.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of ascarin in the preparation of drugs for preventing or treating depression. Background technique [0002] Depression is one of the most common mental illnesses. It is characterized by significant and persistent depression, often accompanied by serious psychological and physical disorders, and is extremely harmful to human health. The world invests a lot in its research and development every year, bringing great benefits to the society. serious burden on the family. In addition, patients with depression are often accompanied by changes in eating patterns related to insomnia, lethargy, overeating, weight loss or anorexia, and more serious symptoms include some extreme symptoms such as circadian rhythm and endocrine disorders. At present, there are at least 90 million depression patients in my country, and only 5% of them have received treatment; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/39A61K36/43A61K9/20A61P25/24
CPCA61K31/7048A61K36/39A61K36/43A61K9/2059A61P25/24
Inventor 王汉卿佟月杨橹楠陶伟伟刘颖赵建军雍婧姣王庆贺凯张霞冯军王建寰高晓娟付慧玲柳全霞曾亮杨彩艳
Owner NINGXIA MEDICAL UNIV
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