Method for judging influence on protein interaction based on mutation information

A protein interaction and point mutation technology, applied in the field of protein interaction impact judgment based on mutation information, can solve problems such as classification and labeling, lack of research data, research obstacles, etc., to achieve the effect of improving judgment

Active Publication Date: 2020-05-08
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
View PDF8 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, research in this area mainly focuses on the effect of mutations on protein binding free energy, and there is no research that directly judges the effect of protein interactions caused by mutations through sequence information.
The main problems in this research are: 1) The available research data is insufficient, and there is not enough experimentally verified labeling data as a support to carry out related research. At present, most protein inte

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for judging influence on protein interaction based on mutation information
  • Method for judging influence on protein interaction based on mutation information
  • Method for judging influence on protein interaction based on mutation information

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, but not as a limitation of the present invention.

[0018] see figure 1 As shown, the method for judging the impact of protein interaction based on mutation information in the present invention includes three parts: data collection and screening, feature selection and extraction, and model building. In the present invention, the input protein mutation is predicted by the trained deep learning model, and the protein mutation is divided into two types, one is that it will have a negative impact on protein interaction, and the other is that it has no effect.

[0019] In the data collection and screening phase, the data set (S1) given in the article published in the Naturecommunications journal IMEx organization in January 2019 was used in the development process. This data set contains protein sequence point mutation data collected by IMEx alliance...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for judging the influence on protein interaction based on mutation information. The method is a judgment tool (MIPPI) for judging whether single-point mutation in a protein can generate negative influence on the protein interaction of the original gene, and comprises three parts of data collection and screening, feature selection and extraction, and model establishment. According to the technical scheme, an intuitive auxiliary judgment standard for the influence of mutation on protein interaction can be provided for related researchers of gene and protein mutation, the influence on protein interaction caused by mutation is judged mainly based on protein sequence mutation information, and judgment on the severity degree of protein mutation can be improved.

Description

technical field [0001] The invention belongs to the technical field of biological computers, and in particular relates to a method for judging the influence of protein interaction based on mutation information. Background technique [0002] Gene mutations are ubiquitous in the human genome. According to literature reports, each person's gene contains an average of about 175 mutation points, and each person carries more than 3 harmful mutations on average. Most of the gene mutation sites are located in the non-coding region of the genome, and only a few fall in the coding region. Missense mutations in the coding region can lead to changes in protein coding, thereby changing the structure and function of proteins, and affecting related biological processes and functions. At present, a large number of diseases are known to be related to gene mutations, typically mental diseases, such as autism, obsessive-compulsive disorder, Alzheimer's disease, bipolar disorder, etc. Other re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G16B25/00G16B30/00G16B40/00
CPCG16B25/00G16B30/00G16B40/00Y02A90/10
Inventor 林关宁钱威
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap