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Use of low molecular weight chondroitin sulfate in preparing daily chemical products and external preparations

A technology of chondroitin sulfate and low molecular weight, which is applied in the field of low molecular weight chondroitin sulfate to prepare daily chemical products and external preparations, and can solve the problems that the application of chondroitin sulfate has not yet been discovered.

Active Publication Date: 2021-06-18
北京璞棠生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no application of low molecular weight chondroitin sulfate in daily chemical products or external preparations

Method used

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  • Use of low molecular weight chondroitin sulfate in preparing daily chemical products and external preparations
  • Use of low molecular weight chondroitin sulfate in preparing daily chemical products and external preparations
  • Use of low molecular weight chondroitin sulfate in preparing daily chemical products and external preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1. Preparation of low molecular weight chondroitin sulfate

[0046] The steps of preparing low-molecular-weight chondroitin sulfate by catalytic oxidation are as follows: dissolve chondroitin sulfate in water, add copper sulfate (National Medicine Reagent), heat to 50°C, then add hydrogen peroxide solution (National Medicine Reagent), and react at a constant temperature of 50°C After 4h, the heating was stopped. The reaction solution was dialyzed overnight using a dialysis bag with a molecular weight cut-off of 500-15000 (Shanghai Yuanye Biotechnology Co., Ltd.), and the solution was lyophilized to obtain white low molecular weight chondroitin sulfate.

Embodiment 2

[0047] Example 2. Bioactivity identification of low molecular weight chondroitin sulfate

[0048] First, prepare low molecular weight chondroitin sulfate, the steps are as follows: dissolve 0.5g chondroitin sulfate in 100ml water, add 0.032g (0.2mmol) of copper sulfate (Sinopharm Reagent), heat to 50°C, then add 5ml hydrogen peroxide 30% Solution (Sinopharm Reagent). After 4 hours of constant temperature reaction at 50°C, the heating was stopped. The reaction solution was dialyzed overnight using a dialysis bag with a molecular weight cut-off of 1000 (Shanghai Yuanye Biotechnology Co., Ltd.). The solution was lyophilized to obtain 0.2 g of white low molecular weight chondroitin sulfate. Entrust the Institute of Metal Research, Chinese Academy of Sciences to use gel permeation chromatography (Shimadzu LC-20AT) and gel permeation chromatography column (Viscotek, A3000, Col 300*8.0mm) to carry out gel permeation chromatography to the low molecular weight chondroitin sulfate obt...

Embodiment 3

[0089] Embodiment 3. Preparation of Acne Gel

[0090] No. 1 gel prescription: by weight (%), carbomer 0.7%, glycerin 5%, propylene glycol 5%, phenoxyethanol 0.5%, essence 0.05%, citric acid 0.05%, low molecular weight chondroitin sulfate (molecular weight 3000) 1%, the balance is deionized water.

[0091] No. 2 gel prescription: by weight (%), carbomer 0.7%, glycerin 5%, propylene glycol 5%, phenoxyethanol 0.5%, essence 0.05%, citric acid 0.05%, low molecular weight chondroitin sulfate (molecular weight 800) 1%, and the balance is deionized water.

[0092] No. 3 gel prescription: by weight (%), carbomer 0.7%, glycerin 5%, propylene glycol 5%, phenoxyethanol 0.5%, essence 0.05%, citric acid 0.05%, low molecular weight chondroitin sulfate (molecular weight 15000) 1%, the balance is deionized water.

[0093] No. 4 gel composition: by weight (%), carbomer 0.7%, glycerin 5%, propylene glycol 5%, phenoxyethanol 0.5%, essence 0.05%, citric acid 0.05%, chondroitin sulfate (molecula...

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Abstract

The invention relates to pharmaceutical technology, in particular to the use of low molecular weight chondroitin sulfate in preparing daily chemical products or external preparations. The molecular weight range of the low molecular weight chondroitin sulfate is 500-15000, preferably 1000-5000. The weight percent content of the low molecular weight chondroitin sulfate in the daily chemical product or external preparation is 0.0001-99%, preferably 0.001-5%. The daily chemical products and external preparations can effectively relieve and prevent inflammation of the skin or oral mucosa, improve symptoms such as redness, itching, pain, etc., promote the elimination of human skin acne, promote the healing of acne muscles, enhance skin cell activity, resist oxidation or reduce hair loss. fall off.

Description

technical field [0001] The invention relates to pharmaceutical technology, in particular to the use of low molecular weight chondroitin sulfate in preparing daily chemical products and external preparations. Background technique [0002] Chondroitin Sulfate (CS) is a polysaccharide mainly composed of repeating disaccharide units linked by β(1-3) N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA). Currently commercialized chondroitin is mainly extracted from the cartilage tissues of pigs, cattle, chickens, ducks, sharks, sturgeons and other animals. Chondroitin sulfate is considered to have various pharmacological activities such as relieving osteoarthritis, lowering blood lipid and blood sugar, anti-cancer metastasis, promoting cell growth, and promoting skin healing. At present, chondroitin sulfate is used in daily cosmetics mainly for hydrating and moisturizing, and it is a common chondroitin sulfate that has not been treated with low molecular weight. It has a rel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61P17/00A61P17/04A61P17/10A61P17/14A61P1/02A61K8/73A61Q19/10A61Q19/00A61Q11/00A61Q5/12
CPCA61K31/737A61P17/00A61P17/04A61P17/10A61P17/14A61P1/02A61K8/73A61Q19/10A61Q19/00A61Q11/00A61Q5/12
Inventor 田志清谭岸朱水芳丛浩龙姜帆朱松阳
Owner 北京璞棠生物科技有限公司
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