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Curcumin multi-layer emulsion with colon-targeted transport function and its preparation method and application

A colon-targeting, curcumin technology, applied in the directions of emulsion delivery, medical preparations of inactive ingredients, pharmaceutical formulations, etc., can solve the problems of low solubility and dissolution rate of curcumin, limited curcumin application, low bioavailability, etc. problems, to improve the steric hindrance effect, avoid adverse environmental effects, and achieve good biocompatibility

Active Publication Date: 2022-01-28
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the strong intermolecular and intramolecular hydrogen bonds, the solubility and dissolution rate of curcumin in water are extremely low, which makes the compatibility of curcumin with other food raw materials during food processing extremely poor, and the bioavailability in the body is extremely low , which limits the application of curcumin in the fields of food and medicine

Method used

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  • Curcumin multi-layer emulsion with colon-targeted transport function and its preparation method and application
  • Curcumin multi-layer emulsion with colon-targeted transport function and its preparation method and application
  • Curcumin multi-layer emulsion with colon-targeted transport function and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0088] One, the preparation method of curcumin multilayer emulsion transmission system in the present embodiment comprises the following steps (the preparation process flow chart sees Figure 17 ):

[0089] 1. Weigh a certain amount of curcumin, disperse it in medium-chain triglycerides, so that the concentration of curcumin is 10 mg / mL, heat and stir at 60° C. in the dark for 3 hours, and prepare the curcumin oil phase.

[0090] Accurately weigh 2.0g of whey protein isolate and dissolve it in 50mL of deionized water, stir under a magnetic stirrer for 4 hours at a constant temperature, and use deionized water to make up to 100mL to obtain a 2.0% (w / v) whey protein isolate solution.

[0091] Mix the curcumin oil phase with the whey protein isolate solution with a concentration of 2.0% (w / v) according to the volume ratio of 1:9, adjust the pH to 7, and homogenize at 11000r / min for 3min at 25°C to prepare curcumin O / W type primary emulsion.

[0092] 2. Accurately weigh 0.5g chi...

Embodiment 2

[0105] The preparation method of curcumin multilayer emulsion transmission system in the present embodiment may further comprise the steps:

[0106] 1. Weigh a certain amount of curcumin, disperse it in medium-chain triglycerides, so that the concentration of curcumin is 12 mg / mL, heat and stir at 70° C. in the dark for 2.5 hours, and prepare the curcumin oil phase.

[0107] Accurately weigh 0.5g of whey protein isolate and dissolve it in 50mL of deionized water, stir for 4 hours at a constant temperature under a magnetic stirrer, and dilute to 100mL with deionized water to obtain a 0.5% (w / v) whey protein isolate solution.

[0108] Mix the curcumin oil phase with the whey protein isolate solution with a concentration of 0.5% (w / v) according to the volume ratio of 1:6, adjust the pH to 6.5, and homogenize at 13000r / min for 5min at 25°C to prepare curcumin O / W type primary emulsion.

[0109]2. Accurately weigh 0.1g of chitosan and dissolve it in 50mL of 1% (v / v) acetic acid so...

Embodiment 3

[0115] The preparation method of curcumin multilayer emulsion transmission system in the present embodiment may further comprise the steps:

[0116] 1. Weigh a certain amount of curcumin, disperse it in medium-chain triglycerides, so that the concentration of curcumin is 11 mg / mL, heat and stir at 80° C. in the dark for 2 hours, and prepare the curcumin oil phase.

[0117] Accurately weigh 1.0 g of whey protein isolate and dissolve it in 50 mL of deionized water, stir for 4 hours at a constant temperature under a magnetic stirrer, and dilute to 100 mL with deionized water to obtain a 1.0% (w / v) whey protein isolate solution.

[0118] Mix the curcumin oil phase with the whey protein isolate solution with a concentration of 1.0% (w / v) according to the volume ratio of 1:15, adjust the pH to 5, and homogenize at 12000r / min for 5min at 25°C to prepare curcumin O / W type primary emulsion.

[0119] 2. Accurately weigh 0.2g of chitosan and dissolve it in 50mL of 1% (v / v) acetic acid s...

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Abstract

The invention provides a curcumin multi-layer emulsion with a colon-targeted transport function, a preparation method and an application thereof. In the present invention, the medium-chain triglyceride solution of curcumin is used as the oil phase, the whey protein isolate is used as the emulsifier and the polyelectrolyte in the inner layer, chitosan is used as the polyelectrolyte in the second layer, and carboxymethyl konjac glucomannan is used as the polyelectrolyte in the second layer. The outer polyelectrolyte, curcumin multilayer emulsion prepared by electrostatic layer-by-layer self-assembly technology. The curcumin colon targeted transmission multilayer emulsion provided by the invention has small particle size, good dispersion and storage stability, low release in simulated gastric juice, and low release in simulated colonic fluid containing β-mannanase High, with good colon-targeted delivery performance; in vivo evaluation results show that the bioavailability of curcumin is significantly improved after the formation of multilayer emulsion, so the multilayer emulsion of the present invention can be used as the colon-targeted delivery system of curcumin.

Description

technical field [0001] The invention belongs to the technical field of targeted release, and in particular relates to a curcumin multilayer emulsion with a colon targeted delivery function and a preparation method and application thereof. Background technique [0002] Curcumin is the active ingredient of the perennial herb turmeric, which has many functions such as anti-oxidation, anti-inflammation, anti-cancer, promoting wound healing and preventing neurodegenerative diseases. It can also interfere with various cell signal transduction pathways, such as inhibiting colon cancer Cell cycle progression, reduction of angiogenesis and induction of apoptosis, etc. Due to the strong intermolecular and intramolecular hydrogen bonds, the solubility and dissolution rate of curcumin in water are extremely low, which makes the compatibility of curcumin with other food raw materials during food processing extremely poor, and the bioavailability in the body is extremely low , which limi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/12A61K47/42A61K47/36A61P29/00A23L33/00
CPCA61K9/107A61K31/12A61K47/42A61K47/36A61P29/00A23L33/00
Inventor 肖军霞黄国清王鲁慧周颖
Owner QINGDAO AGRI UNIV
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