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Curcumin multilayer emulsion with colon-targeted delivery function, and preparation method and application thereof

A colon-targeting and curcumin technology, which is applied in the direction of emulsion delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of low solubility and dissolution rate of curcumin, restrictions on the application of curcumin, low bioavailability, etc. problems, to achieve the effect of improving steric hindrance effect, avoiding the influence of adverse environment, and good biocompatibility

Active Publication Date: 2020-05-08
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the strong intermolecular and intramolecular hydrogen bonds, the solubility and dissolution rate of curcumin in water are extremely low, which makes the compatibility of curcumin with other food raw materials during food processing extremely poor, and the bioavailability in the body is extremely low , which limits the application of curcumin in the fields of food and medicine

Method used

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  • Curcumin multilayer emulsion with colon-targeted delivery function, and preparation method and application thereof
  • Curcumin multilayer emulsion with colon-targeted delivery function, and preparation method and application thereof
  • Curcumin multilayer emulsion with colon-targeted delivery function, and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0088] One, the preparation method of curcumin multilayer emulsion transmission system in the present embodiment comprises the following steps (the preparation process flow chart sees Figure 17 ):

[0089] 1. Weigh a certain amount of curcumin, disperse it in medium-chain triglycerides, so that the concentration of curcumin is 10 mg / mL, heat and stir at 60° C. in the dark for 3 hours, and prepare the curcumin oil phase.

[0090] Accurately weigh 2.0g of whey protein isolate and dissolve it in 50mL of deionized water, stir under a magnetic stirrer for 4 hours at a constant temperature, and use deionized water to make up to 100mL to obtain a 2.0% (w / v) whey protein isolate solution.

[0091] Mix the curcumin oil phase with the whey protein isolate solution with a concentration of 2.0% (w / v) according to the volume ratio of 1:9, adjust the pH to 7, and homogenize at 11000r / min for 3min at 25°C to prepare curcumin O / W type primary emulsion.

[0092] 2. Accurately weigh 0.5g chi...

Embodiment 2

[0105] The preparation method of curcumin multilayer emulsion transmission system in the present embodiment may further comprise the steps:

[0106] 1. Weigh a certain amount of curcumin, disperse it in medium-chain triglycerides, so that the concentration of curcumin is 12 mg / mL, heat and stir at 70° C. in the dark for 2.5 hours, and prepare the curcumin oil phase.

[0107] Accurately weigh 0.5g of whey protein isolate and dissolve it in 50mL of deionized water, stir for 4 hours at a constant temperature under a magnetic stirrer, and dilute to 100mL with deionized water to obtain a 0.5% (w / v) whey protein isolate solution.

[0108] Mix the curcumin oil phase with the whey protein isolate solution with a concentration of 0.5% (w / v) according to the volume ratio of 1:6, adjust the pH to 6.5, and homogenize at 13000r / min for 5min at 25°C to prepare curcumin O / W type primary emulsion.

[0109]2. Accurately weigh 0.1g of chitosan and dissolve it in 50mL of 1% (v / v) acetic acid so...

Embodiment 3

[0115] The preparation method of curcumin multilayer emulsion transmission system in the present embodiment may further comprise the steps:

[0116] 1. Weigh a certain amount of curcumin, disperse it in medium-chain triglycerides, so that the concentration of curcumin is 11 mg / mL, heat and stir at 80° C. in the dark for 2 hours, and prepare the curcumin oil phase.

[0117] Accurately weigh 1.0 g of whey protein isolate and dissolve it in 50 mL of deionized water, stir for 4 hours at a constant temperature under a magnetic stirrer, and dilute to 100 mL with deionized water to obtain a 1.0% (w / v) whey protein isolate solution.

[0118] Mix the curcumin oil phase with the whey protein isolate solution with a concentration of 1.0% (w / v) according to the volume ratio of 1:15, adjust the pH to 5, and homogenize at 12000r / min for 5min at 25°C to prepare curcumin O / W type primary emulsion.

[0119] 2. Accurately weigh 0.2g of chitosan and dissolve it in 50mL of 1% (v / v) acetic acid s...

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Abstract

The invention provides a curcumin multilayer emulsion with a colon-targeted delivery function, and a preparation method and application thereof. The curcumin multilayer emulsion is prepared by using amedium-chain triglyceride solution in curcumin as an oil phase, using whey protein isolate as an emulsifier and an inner-layer polyelectrolyte, using chitosan as a second-layer polyelectrolyte and using carboxymethyl konjac glucomannan as an outer-layer polyelectrolyte through an electrostatic layer-by-layer self-assembly technology. The curcumin colon-targeted delivery multilayer emulsion provided by the invention has the advantages that the particle size is small; the dispersity and the storage stability are high; the release amount in simulated gastric fluid is low; the release amount in simulated colon fluid containing beta-mannase is high; and good colon-targeted delivery performance is realized. In vivo evaluation results show that the bioavailability of the curcumin after the multilayer emulsion is formed is obviously improved, so that the curcumin multilayer emulsion provided by the invention can be used as a curcumin colon-targeted delivery system.

Description

technical field [0001] The invention belongs to the technical field of targeted release, and in particular relates to a curcumin multilayer emulsion with a colon targeted delivery function and a preparation method and application thereof. Background technique [0002] Curcumin is the active ingredient of the perennial herb turmeric, which has many functions such as anti-oxidation, anti-inflammation, anti-cancer, promoting wound healing and preventing neurodegenerative diseases. It can also interfere with various cell signal transduction pathways, such as inhibiting colon cancer Cell cycle progression, reduction of angiogenesis and induction of apoptosis, etc. Due to the strong intermolecular and intramolecular hydrogen bonds, the solubility and dissolution rate of curcumin in water are extremely low, which makes the compatibility of curcumin with other food raw materials during food processing extremely poor, and the bioavailability in the body is extremely low , which limi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/12A61K47/42A61K47/36A61P29/00A23L33/00
CPCA61K9/107A61K31/12A61K47/42A61K47/36A61P29/00A23L33/00
Inventor 黄国清肖军霞王鲁慧周颖
Owner QINGDAO AGRI UNIV
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