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Ginsenoside and ultrasonic extraction method thereof

A technology of ginsenosides and total ginsenosides, applied in chemical instruments and methods, glycosides, glycosides, etc., can solve the problems of high impurity content in extraction products, low extraction efficiency, and long extraction time

Inactive Publication Date: 2020-04-28
王传涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these traditional extraction methods have many unavoidable technical defects, such as low extraction efficiency, such as serious damage to active ingredients, long extraction time, and high content of impurities in the extracted products; although supercritical extraction has a short extraction time and simple operation, the impurities in the extracted products The content is relatively high, it is difficult to separate ginsenoside monomers, and it is difficult to guarantee the quality of ginsenoside products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1: Ultrasonic Extraction of Ginsenosides

[0086] The implementation steps of this embodiment are as follows:

[0087] A. Sample processing

[0088] Grind the Panax notoginseng medicinal material containing ginsenoside into 40 mesh powder, then add the ethanol aqueous solution with a concentration of 70% by volume according to the ratio of 1:15 of the drug powder in grams to the aqueous ethanol solution in milliliters, mix well, and then put it under room temperature Soak for 40min;

[0089] B. Ultrasonic extraction

[0090] Repeat the ultrasonic extraction of the soaked material obtained in step A at a temperature of 30°C and an ultrasonic frequency of 80KHz for 3 times, each time for 34 minutes, and the combined extracts are distilled under reduced pressure to recover ethanol at a pressure of 0.01MPa, and concentrated to obtain a relative An extract rich in ginsenosides with a density of 1.18;

[0091] C. Silica gel adsorption

[0092] Use water to mix th...

Embodiment 2

[0097] Embodiment 2: Ultrasonic extraction of ginsenosides

[0098] The implementation steps of this embodiment are as follows:

[0099] A. Sample processing

[0100] Crush the ginseng medicinal material containing ginsenosides into 30-mesh powder, then add an aqueous ethanol solution with a concentration of 86% by volume according to the ratio of 1:12 of the drug powder in grams to the aqueous ethanol solution in milliliters, mix well, and then soak at room temperature 26min;

[0101] B. Ultrasonic extraction

[0102] Repeat the ultrasonic extraction of the soaked material obtained in step A at a temperature of 60°C and an ultrasonic frequency of 40KHz for 4 times, each time for 20 minutes, and the combined extracts are distilled under reduced pressure at a pressure of 0.02MPa to recover ethanol, and concentrated to obtain a relative An extract rich in ginsenosides with a density of 1.10;

[0103] C. Silica gel adsorption

[0104]Use water to mix the extract rich in gins...

Embodiment 3

[0109] Example 3: Ultrasonic extraction of ginsenosides

[0110] The implementation steps of this embodiment are as follows:

[0111] A. Sample processing

[0112] Grind the American ginseng medicinal material containing ginsenoside into 60-mesh powder, then add an aqueous ethanol solution with a concentration of 95% by volume according to the ratio of 1:5 of the drug powder in grams to the aqueous ethanol solution in milliliters, mix well, and then soak at room temperature 20min;

[0113] B. Ultrasonic extraction

[0114] Let the soaked material obtained in step A repeat ultrasonic extraction 3 times under the conditions of temperature 40°C and ultrasonic frequency 60KHz, each time ultrasonic extraction is 60min, the combined extracts are distilled under reduced pressure to recover ethanol under the condition of pressure 0.04MPa, and concentrated to obtain relative An extract rich in ginsenosides with a density of 1.14;

[0115] C. Silica gel adsorption

[0116] Use wate...

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Abstract

The invention relates to ginsenoside and an ultrasonic extraction method thereof. The extraction method comprises the steps of sample treatment, ultrasonic extraction, silica gel adsorption, eluent decolorization, concentration drying and the like. The extraction method is short in extraction time, low in extraction temperature and high in extraction efficiency. Besides, an ethanol solution is adopted as a solvent in the whole extraction and separation process, other toxic organic solvents are not used, and environmental pollution is small while the extraction efficiency is guaranteed. According to the method, a chromatographic separation technology is adopted, and impurities in the extract are thoroughly removed, so that the quality of the ginsenoside product is obviously improved.

Description

【Technical field】 [0001] The invention belongs to the technical field of biomedicine. More specifically, the present invention relates to a kind of ginsenoside, and also relates to the ultrasonic extraction method of said ginsenoside. 【Background technique】 [0002] Ginsenosides (Ginsenosides) are a kind of sterol compounds, triterpene saponins, which mainly exist in medicinal materials of the genus Panax genus, and have anti-tumor, anti-arrhythmic, anti-aging and immune-enhancing effects. Ginsenosides are considered active components in ginseng and thus have been a hot target for research. Because ginsenosides affect multiple metabolic pathways, their efficacy is also complex, and the monomeric components of various ginsenosides are difficult to separate. [0003] At present, domestic ginsenoside extraction methods mainly include traditional solvent extraction, water extraction and alcohol precipitation, supercritical extraction, and ultrasonic extraction. However, these...

Claims

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Application Information

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IPC IPC(8): C07J17/00C07G3/00
CPCC07J17/005C07G3/00
Inventor 王传涛
Owner 王传涛
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