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Medical tracheal catheter, tracheal catheter coating layer, and preparation method thereof

A tracheal catheter and coating technology, which is applied to tracheal intubation, catheter, coating and other directions, can solve the problems of limited action time, drying and falling off, and is not ideal, and achieves good technical effect, good coating stability, and increased The effect of patient tolerance

Inactive Publication Date: 2020-04-21
卢静 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the action time of local anesthetics (such as lidocaine solution) is limited, and the local anesthetic gel itself is not stable, and there is a risk of drying out and blocking the airway in the tracheal environment. These measures are not ideal in clinical practice at present. , it is difficult to effectively meet the current clinical needs
In addition, in view of the long-term risks of inflammation, edema and infection in tracheal intubation in clinical practice, common catheter technology cannot meet the current clinical needs, and tracheal catheter products with slow-release anti-inflammatory and anti-infective drugs are relatively rare

Method used

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  • Medical tracheal catheter, tracheal catheter coating layer, and preparation method thereof
  • Medical tracheal catheter, tracheal catheter coating layer, and preparation method thereof
  • Medical tracheal catheter, tracheal catheter coating layer, and preparation method thereof

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preparation example Construction

[0028] The technical solution of the present invention is: a multifunctional drug-eluting coating for medical tracheal catheters and a preparation method thereof, mainly comprising the following steps:

[0029] A. After mixing the 50-99.8% degradable polymer and 0.2-50% drug a, drug b and drug c, add solvent and stir fully to form a stable solution, wherein drugs a, b, and c have a significant effect on the total drug The mass ratio of the content is 0% to 100% respectively;

[0030] B. Use the spraying method (including ultrasonic atomization spraying, atomization spraying and other spraying processes) to spray the solution treated in step A on the surface of the clean basic structure of the endotracheal tube, and keep the tube rotating and reciprocating during the spraying process, so that the coating is evenly covered structure on the surface;

[0031] C. Blow dry with nitrogen gas during the spraying process, so that the solvent on the coating surface can be volatilized a...

Embodiment 1

[0042] The multifunctional drug-eluting coating is the preparation of a loosely coated endotracheal tube of polylactic acid-bupivacaine-hydrocortisone-tacrolimus (macrolides), the steps of which are:

[0043] A. Prepare a solution with the following components: 1 g of polylactic acid, 200 mg of bupivacaine, 100 mg of hydrocortisone, 100 mg of tacrolimus (macrolide), and 10 ml of ethyl acetate.

[0044] B. Stir and disperse the above mixed system at 50 rpm to form a stable solution.

[0045] C. Spray the solution in step B on the cleaned endotracheal tube by atomization spraying method, and dry it with nitrogen gas.

[0046] D. Place the endotracheal tube in a vacuum drying oven at 45°C and dry for 24 hours.

[0047] In this way, a kind of endotracheal tube with local anesthesia and anti-inflammation effect is made, and the surface of the endotracheal tube is sprayed with degradable polymer drug coating by atomization spraying method, and the coating is made of polylactic acid...

Embodiment 2

[0049] The multifunctional drug-eluting coating is the preparation of an endotracheal tube coated with polylactic acid-glycolic acid copolymer-ropivacaine-prednisone, and the steps are as follows:

[0050] A. Prepare a solution with the following components: 1 g of polylactic acid-glycolic acid copolymer, 150 mg of ropivacaine, 50 mg of cortisone, 50 ml of acetone, and 10 ml of N-methylpyrrolidone.

[0051] B. Stir and disperse the above mixed system at 1000 rpm to form a stable solution.

[0052] C. Spray the solution in step B on the cleaned endotracheal tube by ultrasonic atomization spraying method, and dry it with nitrogen gas.

[0053] D. Place the endotracheal tube in a vacuum drying oven at 35°C and dry for 36 hours to obtain it.

[0054] In this way, a kind of endotracheal tube with local anesthesia and anti-inflammation effect is obtained, and the surface of the endotracheal tube is sprayed with degradable polymer drug coating by ultrasonic atomization spraying meth...

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Abstract

The invention relates to a medical tracheal catheter, in particular to a multifunctional drug eluting coating layer on the surface of the medical tracheal catheter and a preparation method of the multifunctional drug eluting coating layer. According to the preparation method, a degradable polymer drug-loaded coating is uniformly sprayed on the surface of the tracheal catheter by adopting an atomization spraying method. The coating layer comprises 50%-99.8% of a degradable polymer, 0.2%-50% of one or more of a local anesthetic a, an anti-inflammatory drug b and an anti-infective drug c. The drug eluting coating layer prepared by the method can realize independent or simultaneous loading of the local anesthetic drug, the anti-inflammatory drug and the anti-infective drug. The coating layer can inhibit bucking reaction, local inflammatory edema, infection and other adverse reactions caused by tracheal intubation by controlling release of carried drugs, reduce the risk of complications andimprove the comfort of patients.

Description

technical field [0001] The invention relates to a medical endotracheal tube, a coating for the endotracheal tube and a preparation method thereof, in particular to a multifunctional drug-eluting coating for the endotracheal tube and a preparation method thereof. Background technique [0002] Endotracheal intubation is a necessary operation for general anesthesia. The purpose is to ensure that the patient's airway is unobstructed during general anesthesia, prevent aspiration, and facilitate airway management. After the operation, the patients entered the recovery period of general anesthesia. Due to the stimulation of the endotracheal tube or secretions, quite a few patients could not tolerate endotracheal intubation. Risk of vascular accidents, incision rebleeding and other events; some patients even remove the endotracheal tube by themselves, causing damage to the tracheal mucosa and vocal cords, ring spoon joint dislocation and other complications. Even if the patient can...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L29/16A61M16/01A61M16/04
CPCA61L29/085A61L29/148A61L29/16A61L2300/402A61L2300/406A61L2300/41A61L2300/43A61L2300/604A61M16/01A61M2205/0205A61M2205/0238A61M16/0402C08L67/04C08L69/00C08L73/02
Inventor 卢静吕磊
Owner 卢静
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