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Methylene blue antioxidant repair polymer nanofiber membrane and preparation method thereof

A nanofiber membrane, methylene blue technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems that methylene blue is not easily absorbed through the skin, does not have the ability to release methylene blue slowly, and has low antioxidant effect, and achieves good skin feel and The effect of airtightness, promotion of transdermal absorption, and safe use

Active Publication Date: 2020-04-14
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Therefore, the technical problem to be solved in the embodiments of the present invention is to overcome the ability of the restorative dressings in the prior art to release methylene blue slowly, and further solve the problem that the methylene blue in the restorative dressings in the prior art is not easy to be absorbed through the skin. The problem of low antioxidant efficacy

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  • Methylene blue antioxidant repair polymer nanofiber membrane and preparation method thereof

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Embodiment 1

[0038] This embodiment provides a methylene blue anti-oxidation repairing polymer nanofiber membrane, which at least includes a three-layer structure of a hydrogel layer-nanofiber silk layer-hydrogel layer. Such as figure 1 As shown, the three-layer structure of a group of hydrogel layer-nanofiber silk layer-hydrogel layer is that the nanofiber silk layer 2 is sandwiched between two hydrogel layers 1 . The methylene blue anti-oxidation repairing polymer nanofiber membrane can also be composed of a three-layer structure of more than two sets of hydrogel layers-nanofiber silk layers-hydrogel layers.

[0039] The hydrogel layer includes chitosan and its derivatives, gel-forming natural macromolecular substances and salt ion substances, and is prepared by self-assembly and complex coagulation of chitosan and its derivatives and gel-forming natural macromolecular substances. The mass fraction of chitosan and its derivatives is 0.1%-50%, the mass fraction of gel-forming natural pol...

Embodiment 2

[0053] This embodiment provides a method for preparing the methylene blue anti-oxidation repairing polymer nanofiber membrane of embodiment 1, comprising the following steps:

[0054] S1. Configuration of electrospinning solution: dissolve a water-insoluble polymer with a mass of 0.01-50 g in an organic solvent to prepare a water-insoluble polymer solution with a mass fraction of 0.1%-50%, and add a mass of 0.01-50g of methylene blue, so that the mass fraction of methylene blue is 0.0001%-10%, to prepare electrospinning solution A;

[0055] S2. Preparation of nanofiber silk layer: electrospinning the electrospinning liquid A with ultra-high voltage and single nozzle, using the plant ultrafine fiber membrane as the receiver, that is, using the plant ultrafine fiber membrane as the skeleton to control the electrospinning The humidity of the environment is 10%-60%, the spinning voltage is 5kV-60kV, the speed of the syringe pump is 1ml / h-7.5ml / h, the distance between the needle ti...

example 1

[0062] The method for preparing the methylene blue anti-oxidation repairing polymer nanofiber membrane is as follows:

[0063] 1. Preparation of electrospinning solution: Dissolve polylactic acid in hexafluoroisopropanol at room temperature, and then add 0.5 g of methylene blue, so that the mass fraction of methylene blue is 0.5%, and the mass fraction of water-insoluble polymer is 15%. The electrospinning solution A.

[0064] 2. Preparation of the hydrogel layer solution: put sodium alginate into deionized water, heat to above 80°C and stir for 1 hour to obtain an aqueous solution of sodium alginate with a mass fraction of 2%; Chitosan with a relative molecular weight greater than 500KDa is dissolved in 1% acetic acid aqueous solution with a concentration of 1% under heating and stirring at 60°C to obtain a 2% chitosan acetic acid aqueous solution; dissolve calcium chloride in deionized water and stir at room temperature After 0.5 hour, a calcium chloride solution with a mas...

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Abstract

The invention discloses a methylene blue antioxidant repair polymer nanofiber membrane and a preparation method, and relates to the technical field of repair dressings. The nanofiber membrane at leastcomprises a three-layer structure of a hydrogel layer, a nanofiber filament layer and hydrogel layers, wherein the hydrogel layer comprises chitosan and derivatives thereof, a gelatinizing natural polymer substance and a salt ion substance; the nanofiber filament layer is sandwiched between the two hydrogel layers, and the nanofiber filament layer is a non-water-soluble polymer filament membranewith a plant superfine fiber membrane as a skeleton; and methylene blue is uniformly distributed in the non-water-soluble polymer filament. By releasing methylene blue step by step, the action time iseffectively prolonged, the transdermal absorption capacity of methylene blue is strong, and the bioavailability is high. During use, a closed environment capable of continuously releasing methylene blue can be formed, a skin lesion part can be subjected to long-time antioxidant repair, and good antibacterial and anti-inflammatory effects are achieved.

Description

technical field [0001] The invention relates to the technical field of restorative dressings, in particular to a methylene blue anti-oxidation repairing polymer nanofiber membrane and a preparation method thereof. Background technique [0002] Oxidative damage can cause a variety of diseases, such as skin aging, tumors and immune damage. Excessive sunlight exposure, high-energy lasers, and photon cosmetic surgery in life will all lead to the accumulation of oxygen free radicals in the skin and the decline in the ability to scavenge free radicals, resulting in excessive free radicals in the body, resulting in acute skin inflammation, sensitivity and barrier. Functional decline. If the skin is under oxidative stress for a long time, it is also prone to pigmentation, resulting in uneven skin tone after sun exposure or surgery, and affecting the mental health of patients. Therefore, it is particularly important to find medical skin care products with strong antioxidant repair ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/20A61L15/24A61L15/26A61L15/28A61L15/40A61L15/42A61L15/44
CPCA61L15/18A61L15/20A61L15/24A61L15/26A61L15/28A61L15/40A61L15/42A61L15/44A61L2300/216C08L67/04C08L5/04C08L5/08C08L29/04
Inventor 唐颖张兆伦刘磊韩真珠
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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